摘要
目的研究脑梗死患者血清尿酸水平与颈动脉粥样硬化斑块及脑梗死的相关性。方法选择我院2015年7月~2017年5月收治的96例脑梗死患者作为研究组,另选择同一时间来我院体检的非脑梗死者88例作为对照组,严格按照我国脑梗死检测标准,采取生化分析仪以及多普勒超声检查,记录所有患者血清尿素水平以及斑块情况,分析血清尿酸水平与颈动脉粥样硬化斑块的相关性。结果经过观察所有患者检查结果看出,研究组血清尿酸水平、颈动脉内膜中层厚度较对照组高(t=36.063,14.805,P<0.05);研究组患者总胆固醇水平无统计学意义(t=0.836,P>0.05),其中高尿酸血症甘油三酯、低密度脂蛋白水平较血清尿酸正常组高,高密度脂蛋白水平较血清尿酸正常组低(t=7.952,-2.175,4.112,P<0.05);颈动脉内膜中层厚度正常组血清尿酸水平明显较其他两组降低,差异有统计学意义(F=105.74,P<0.05)。结论脑梗死患者血清尿酸水平较正常者高,因此高尿酸血症属于脑梗死中主要风险因素,并且与颈动脉粥样硬化斑块形成具有一定相关性。
Objective To study the correlation of serum uric acid levels with carotid atherosclerotic plaque and cerebral infarction. Methods Ninety-six patients with cerebral infarction treated in our hospital from July 2015 to May 2017 were selected as study group.Eighty-eight cases without cerebral infarction which in our hospital for physical examination at the same time were selected as control group.According to the standard of cerebral infarction in China,the biochemical analyzer and doppler ultrasound were used to record the serum urea level and plaque in all patients.The serum uric acid levels as well as its correlation with carotid atherosclerotic plaque were observed. Results It was known that the serum uric acid levels and intima-media thickness（IMT） of study group were higher than those of control group（t=36.063,14.805,P〈0.05）.The total cholesterol levels of study group were not significantly different（t=0.836,P〉0.05）,and the index of triglyceride and low density lipoprotein of hyperuricemia patients were higher than those of normal uric acid group,the level of high density lipoprotein of hyperuricemia patients were lower than that of normal uric acid group（t=7.952,-2.175,4.112,P〈0.05）.The level of serum uric acid in the normal carotid intima-media thickness group was significantly lower than that in the other two groups（F=105.74, P〈0.05）. Conclusion The serum uric acid levels of cerebral infarction patients are higher than that of normal patients.Therefore, the hyperuricemia is the major risk factor of cerebral infarction,which it is correlated with the formation of carotid atherosclerotic plaque.
作者
黄汉烽
HUANG Hanfeng(Department of Third Internal Medicine,Jiexi County People＇s Hospital,Jiexi 515400,China)
出处
《中国医药科学》
2018年第9期194-196,共3页
China Medicine And Pharmacy
关键词
相关性
粥样硬化斑块
脑梗死
血清尿酸
Correlation
Carotid atherosclerotic plaque
Cerebral infarction
Serum uric acid
