摘要
目的通过分析含莫西沙星方案治疗老年耐药肺结核的疗效,探讨老年耐药肺结核的成因及治疗措施。方法 2005年10月～2010年11月收治资料完整的100例老年耐药肺结核病例,分为治疗组50例,对照组50例。治疗组应用含莫西沙星联合抗结核化疗药物,对照组应用含氧氟沙星的抗结核化疗药物。两组其他抗结核药物组成完全相同,疗程1年。结果两组病例疗程结束时,痰结核菌转阴率治疗组94.0%,明显高于对照组78.0%(P<0.05)。治疗组病灶吸收和空洞愈合率分别为84.0%和60.0%;对照组病灶吸收率和空洞愈合率分别为68.0%和42.0%(P<0.05)。结论含莫西沙星方案在痰菌阴转、病灶吸收、空洞愈合方面均明显优于含氧氟沙星方案。
Objective To observe the effect of moxifloxacin in the treatment of multi-drug resistant tuberculosis （MDR-TB） patients and probe the reason and treatment of it. Methods One hundred MDR-TB patients who were admitted to hospital and who had completed clinical data for the treatment were integrated for the research. The duration for the treatment was October 2005 and November 2010.The patients were divided into therpeutic group（n=50）and control group（n=50）. The patients in the therpeutic group were treated with moxifloxacin for a consecutive one year period while the patients in the control group were treated with moxifloxacin also 12 months.The other medications used for the both groups were the same. Results At the end of the treatment period,the therpeutic group had achieved better clinicaleffects than the control group in sputum positive-turned-negative rate（94.0% and 78.0%,respectively for the two groups,P〈0.05）,in lesion absorption rate （84.0% arid 68.0% respectively for the groups：P〈0.05）and in cavity closure rate（60.0% and 42.0% for the groups：P〈0.05）. Conclusion Moxifloxacin has better clinical effects than ofloxacin in the treatment of multi-drug resistant tuberculosis patients.
出处
《中国现代医生》
2011年第12期134-135,146,共3页
China Modern Doctor
关键词
肺结核
耐药
莫西沙星
氧氟沙星
Pulmonary tuberculosis
MDR-TB
Moxifloxacin
Ofioxacin
