摘要
肿瘤的进展是一多因素、多环节、多阶段的过程,其中肿瘤血管生成起关键作用,近来研究表明肿瘤及肿瘤基质细胞分泌的白细胞介素8(IL8)也是一重要的血管生成因子,它可通过肿瘤及肿瘤血管内皮细胞表面的受体,直接或间接促进肿瘤细胞的增生、新生血管的形成,从而促进肿瘤的生长和转移。
Tumor progression is a multistep process including angiogenesis, tumor cell proliferation, migration and tumor-endothelial cell interaction, in which angiogenesis is a key event of tumor growth and metastasis. Recent studies had suggested IL-8 is not only an inflammation cytokine ,but also an angiogenic and mitogenic chemokine. IL-8 ,which secreted by tumor and stromal cells, might stimulate tumor cell proliferation, migration, angiogensis and involve in the invision and metastasis of tumor.
出处
《国际免疫学杂志》
CAS
2006年第4期260-263,共4页
International Journal of Immunology
