摘要
目的研究糖尿病足患者血清IGF-1和VEGF水平与糖尿病足部溃疡或坏疽的关系。方法分别采用放射免疫分析法和定量双抗体夹心ELISA法检测23例糖尿病足患者血清IGF-1和VEGF水平,并与健康人和2型糖尿病患者进行比较。结果糖尿病足患者血清IGF-1和VEGF水平显著低于糖尿病患者和健康对照组(P<0.05)。结论生长因子IGF-1和VEGF是糖尿病足发生和发展的重要影响因素,IGF-1和VEGF水平低下可能是糖尿病足部溃疡经久不愈的重要原因。
objective ： To investigate the correlation of the serum concentration of insulin - like growth factor - 1 （ IGF - 1 ） and vascular endothelial growth factor （VEGF） in diabetic foot patients with the incidence of diabetic foot ulcer or necrosis. Methods： The serum concentration of IGF - 1 and VEGF in 23 diabetic foot patients were determined with radioimmunoassay and enzyme linked immunosorbent assay （ELISA） for quantitative analysis respectively and compared with that of normal subjects and type 2 diabetes patients. Results ： The serum concentration of IGF - 1 and VEGF in patients with diabetic foot were obviously lower than those of diabetic and normal control group （ P 〈 0. 05 ） . conclusion ： IGF - 1 and VEGF have an important effect on the occurrence anddevelopment of diabetic foot, the lower levers of IGF - 1 and VEGF may be the important cause that diabetic foot ulcer can not cicatrize for a long time.
出处
《中国优生与遗传杂志》
2006年第5期22-23,共2页
Chinese Journal of Birth Health & Heredity
基金
深圳市科技计划项目(20050190)
关键词
糖尿病足
胰岛素样生长因子-1
血管内皮生长因子
Diabetic foot
Insulin - like growth factor - 1 （ IGF - 1 ）
Vascular endothelial growth factor （VEGF）
