In order to search a effective therapy for viral myocarditis, antivial activity of Rheum officinale on Coxsackieivirus B 3 (CVB 3) was evaluated in BALB/C mice. After being determined optium scheme with orthogonal des...In order to search a effective therapy for viral myocarditis, antivial activity of Rheum officinale on Coxsackieivirus B 3 (CVB 3) was evaluated in BALB/C mice. After being determined optium scheme with orthogonal design, mice infected with CVB 3 were treated with Rheum officinale , ribavirin and 0.9% NaCl. The survival rates of the mice were 35%,5% and 5%;Median survival time were 23,11 and 10.5 days;Infectious viral titers were 10 -3.2 ,10 -4.7 and 10 -4.7 TCID 50 / 0.1 mL repectively, The lesions of cardiac tissues lightened in mice treated with Rheum offinicale . These results showed that Rheum officinale was effective in treatment of CVB 3 infected mice. The study provided scientific basis for further research and widen antiviral spectrum of Rheum officinale .展开更多
The research of the cooperative antivirus activities was carried out using amantadine, ribavirin and herby houttuynia. The inhibitory effect of CPE caused by influenza virus A\-3 in MDCK cell and the therapeutic effec...The research of the cooperative antivirus activities was carried out using amantadine, ribavirin and herby houttuynia. The inhibitory effect of CPE caused by influenza virus A\-3 in MDCK cell and the therapeutic effect on BALB/c mice pneumonia caused by influenza virus FM1 were examined and analyzed when amantadine, ribavirin and herby houttuynia were used alone or associatively. The results show that the concentrations of amantadine,ribavirin and herby houttuynia with same effect were 256, 512 and 1024 times cooperatively as many as alone in vitro, respectively.The ablities of treating pneumonia of mice when three kinds of drugs were used cooperatively were far higher than those alone in BALB/c mice.展开更多
文摘In order to search a effective therapy for viral myocarditis, antivial activity of Rheum officinale on Coxsackieivirus B 3 (CVB 3) was evaluated in BALB/C mice. After being determined optium scheme with orthogonal design, mice infected with CVB 3 were treated with Rheum officinale , ribavirin and 0.9% NaCl. The survival rates of the mice were 35%,5% and 5%;Median survival time were 23,11 and 10.5 days;Infectious viral titers were 10 -3.2 ,10 -4.7 and 10 -4.7 TCID 50 / 0.1 mL repectively, The lesions of cardiac tissues lightened in mice treated with Rheum offinicale . These results showed that Rheum officinale was effective in treatment of CVB 3 infected mice. The study provided scientific basis for further research and widen antiviral spectrum of Rheum officinale .
文摘The research of the cooperative antivirus activities was carried out using amantadine, ribavirin and herby houttuynia. The inhibitory effect of CPE caused by influenza virus A\-3 in MDCK cell and the therapeutic effect on BALB/c mice pneumonia caused by influenza virus FM1 were examined and analyzed when amantadine, ribavirin and herby houttuynia were used alone or associatively. The results show that the concentrations of amantadine,ribavirin and herby houttuynia with same effect were 256, 512 and 1024 times cooperatively as many as alone in vitro, respectively.The ablities of treating pneumonia of mice when three kinds of drugs were used cooperatively were far higher than those alone in BALB/c mice.
