Objective To investigate the relationship between arterial stiffness and pre-diabetes when assessed by the new glycosylated hemoglobin Ale （HbAlc） 5.7%-6.4% criterion or by impaired fasting glucose in middle aged Ch...Objective To investigate the relationship between arterial stiffness and pre-diabetes when assessed by the new glycosylated hemoglobin Ale （HbAlc） 5.7%-6.4% criterion or by impaired fasting glucose in middle aged Chinese. Methods 1122 adults aged 55 years or younger in the health examination centers for physical check-ups were enrolled in the two large-sized Tertiary Comprehensive Hospitals in Beijing from June 2011 to June 2012 after excluding those who previously had been diagnosed or treated as diabetes or cardiovascular disease. Subjects with a diagnosis of pre-diabetes according to impaired fasting glucose （IFG） （fasting plasma glucose （FPG） levels at 5.6-6.9 mmol/L）, HbA^c levels at 5.7%-6.4%, or both, were classified into four groups for observation： （1） Normoglycaemia （HbA^c〈5.7% and FPG 〈5.6 mmol/L）; （2） IFG alone （FPG levels at 5.6-6.9 mmol/L and HbA1c〈5.7% ）; （3） HbAI~ 5.7%-6.4% alone （HbA^c levels at 5.7%-6.4% and FPG 〈5.6 mmol/L）; and （4） both HbA1c 5.7%-6.4% and IFG （l-lbA1~ levels at 5.7%-6.4% and FPG levels at 5.6-6.9 mmol/L）. All subjects were measured for weight, height, waist circumference, blood pressure, fasting plasma glucose, HbA1c, lipid profile and brachial-ankle pulse wave velocity （baPWV）. Results The mean values of baPWV were 1282±8, 1311±10, 1398±30, and 1418_±27 cm/s （Mean_±SE） in Normoglycaemia, HbA~ 5.7%-6.4% alone, IFG alone and the both HbAlc 5.7%-6.4% and IFG groups, respectively. After adjusting for age, gender, blood pressure, BMI and triglyceride, baPWV was significantly higher in subjects with both HbAlc5.7%-6.4% and iFG compared among the subjects with Normoglycaemia （1350±14 vs. 1301±6 cm/s, P=0.002） and HbA1c 5.7%-6.4% alone （1350±14 vs. 1309±8 cm/s, P=0.013）.Conclusion Subjects with pre-diabetes exhibited a greater arterial stiffness.展开更多
Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of...Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.展开更多
目的探讨代谢综合征(MS)与臂踝脉搏波速度(baPWV)的关系。方法选取2010年10月—2013年10月华中科技大学附属协和医院心血管研究中心住院患者692例,将超重或肥胖,腰围:男≥90 cm、女≥80 cm,糖耐量异常或糖尿病,高血压作为MS基本症候群,...目的探讨代谢综合征(MS)与臂踝脉搏波速度(baPWV)的关系。方法选取2010年10月—2013年10月华中科技大学附属协和医院心血管研究中心住院患者692例,将超重或肥胖,腰围:男≥90 cm、女≥80 cm,糖耐量异常或糖尿病,高血压作为MS基本症候群,根据患者组分不同分为MS1组(272例,仅具有MS基本症候群)、MS2组〔270例,具有MS基本症候群伴三酰甘油(TG)异常〕、MS3组〔150例,具有MS基本症候群伴高密度脂蛋白胆固醇(HDL-C)异常〕。另选取同期在本院体检健康者300例作为对照组。采集受试者静脉血,检测总胆固醇(TC)、TG、低密度脂蛋白胆固醇(LDL-C)、HDL-C、空腹血糖(FPG)、餐后2 h血糖(2 h PG)和超敏C反应蛋白(hs-CRP)。并测量受试者baPWV。结果各组年龄、体质量、体质指数(BMI)、腰围、收缩压(SBP)、舒张压(DBP)、脉压(PP)、平均动脉压(MAP)、TC、TG、LDL-C、HDL-C、FPG、2 h PG、hs-CRP和baPWV比较,差异均有统计学意义(P<0.05);其中MS1组、MS2组、MS3组年龄、体质量、BMI、腰围、SBP、DBP、PP、MAP、FPG、2 h PG、hs-CRP和baPWV均高于对照组;MS2组和MS3组体质量、BMI、腰围、SBP、DBP、PP、MAP、FPG、2 h PG和baPWV均高于MS1组;MS3组男性腰围、SBP、PP、TC、LDL-C和baPWV均高于MS2组(P<0.05)。直线相关分析结果显示,MS患者年龄、BMI、SBP、PP、MAP、TG、FPG及2 h PG与baPWV呈正相关,DBP、HDL-C与baPWV呈负相关(P<0.05)。多元线性回归分析结果显示,性别、年龄、BMI、SBP、DBP、2 h PG、TG是MS患者baPWV的因素(P<0.05)。结论 MS患者异常组分越多,引起动脉硬化程度越严重,性别、年龄、BMI、血压、2h PG、TG是MS患者baPWV增加的危险因素,对MS患者进行baPWV检测有利于其心血管事件发生的预测评估。展开更多
基金supported by National Science & Technology Pillar Program(No.2008BAI52B03)
文摘Objective To investigate the relationship between arterial stiffness and pre-diabetes when assessed by the new glycosylated hemoglobin Ale （HbAlc） 5.7%-6.4% criterion or by impaired fasting glucose in middle aged Chinese. Methods 1122 adults aged 55 years or younger in the health examination centers for physical check-ups were enrolled in the two large-sized Tertiary Comprehensive Hospitals in Beijing from June 2011 to June 2012 after excluding those who previously had been diagnosed or treated as diabetes or cardiovascular disease. Subjects with a diagnosis of pre-diabetes according to impaired fasting glucose （IFG） （fasting plasma glucose （FPG） levels at 5.6-6.9 mmol/L）, HbA^c levels at 5.7%-6.4%, or both, were classified into four groups for observation： （1） Normoglycaemia （HbA^c〈5.7% and FPG 〈5.6 mmol/L）; （2） IFG alone （FPG levels at 5.6-6.9 mmol/L and HbA1c〈5.7% ）; （3） HbAI~ 5.7%-6.4% alone （HbA^c levels at 5.7%-6.4% and FPG 〈5.6 mmol/L）; and （4） both HbA1c 5.7%-6.4% and IFG （l-lbA1~ levels at 5.7%-6.4% and FPG levels at 5.6-6.9 mmol/L）. All subjects were measured for weight, height, waist circumference, blood pressure, fasting plasma glucose, HbA1c, lipid profile and brachial-ankle pulse wave velocity （baPWV）. Results The mean values of baPWV were 1282±8, 1311±10, 1398±30, and 1418_±27 cm/s （Mean_±SE） in Normoglycaemia, HbA~ 5.7%-6.4% alone, IFG alone and the both HbAlc 5.7%-6.4% and IFG groups, respectively. After adjusting for age, gender, blood pressure, BMI and triglyceride, baPWV was significantly higher in subjects with both HbAlc5.7%-6.4% and iFG compared among the subjects with Normoglycaemia （1350±14 vs. 1301±6 cm/s, P=0.002） and HbA1c 5.7%-6.4% alone （1350±14 vs. 1309±8 cm/s, P=0.013）.Conclusion Subjects with pre-diabetes exhibited a greater arterial stiffness.
基金supported by the Key Laboratory for Endocrine and Metabolic Diseases,Ministry of Health(1994DP131044)National Nature Science Foundation of China(81170739,81170719,81222008,81370960)+3 种基金Shanghai New Excellent Youth Program(XYQ2011009)Shanghai Health Bureau(2011293)EFSD-CDS-Lilly Program for Collaborative Research between China and Europe(2011)Shanghai Shen Kang Hospital Development Center(SHDC12012301)
文摘Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.
文摘目的探讨代谢综合征(MS)与臂踝脉搏波速度(baPWV)的关系。方法选取2010年10月—2013年10月华中科技大学附属协和医院心血管研究中心住院患者692例,将超重或肥胖,腰围:男≥90 cm、女≥80 cm,糖耐量异常或糖尿病,高血压作为MS基本症候群,根据患者组分不同分为MS1组(272例,仅具有MS基本症候群)、MS2组〔270例,具有MS基本症候群伴三酰甘油(TG)异常〕、MS3组〔150例,具有MS基本症候群伴高密度脂蛋白胆固醇(HDL-C)异常〕。另选取同期在本院体检健康者300例作为对照组。采集受试者静脉血,检测总胆固醇(TC)、TG、低密度脂蛋白胆固醇(LDL-C)、HDL-C、空腹血糖(FPG)、餐后2 h血糖(2 h PG)和超敏C反应蛋白(hs-CRP)。并测量受试者baPWV。结果各组年龄、体质量、体质指数(BMI)、腰围、收缩压(SBP)、舒张压(DBP)、脉压(PP)、平均动脉压(MAP)、TC、TG、LDL-C、HDL-C、FPG、2 h PG、hs-CRP和baPWV比较,差异均有统计学意义(P<0.05);其中MS1组、MS2组、MS3组年龄、体质量、BMI、腰围、SBP、DBP、PP、MAP、FPG、2 h PG、hs-CRP和baPWV均高于对照组;MS2组和MS3组体质量、BMI、腰围、SBP、DBP、PP、MAP、FPG、2 h PG和baPWV均高于MS1组;MS3组男性腰围、SBP、PP、TC、LDL-C和baPWV均高于MS2组(P<0.05)。直线相关分析结果显示,MS患者年龄、BMI、SBP、PP、MAP、TG、FPG及2 h PG与baPWV呈正相关,DBP、HDL-C与baPWV呈负相关(P<0.05)。多元线性回归分析结果显示,性别、年龄、BMI、SBP、DBP、2 h PG、TG是MS患者baPWV的因素(P<0.05)。结论 MS患者异常组分越多,引起动脉硬化程度越严重,性别、年龄、BMI、血压、2h PG、TG是MS患者baPWV增加的危险因素,对MS患者进行baPWV检测有利于其心血管事件发生的预测评估。
