摘要
背景以往有氧运动获益的研究主要关注有氧运动对长期心血管健康及结局的影响,即规律有氧运动可以改善动脉僵硬度,而有研究指出高血糖是增加动脉僵硬度的因素,因此推测高血糖可能削弱了有氧运动改善动脉硬化的作用。目的探究有氧运动对不同血糖水平人群动脉僵硬度的即时影响。方法本研究以既往参加开滦研究2018—2020年第6次随访体检且被抽取参加2020年第5次国民体质监测并于开滦集团旗下四家企业完成功率车二级负荷试验前、后臂踝脉搏波传导速度(baPWV)测量者为研究对象。对研究对象开展流行病学调查,包括一般情况(年龄、高血压、高脂血症、降压药史等)、人体测量学指标〔收缩压(SBP)、舒张压(DBP)等〕和生化检测指标(空腹血糖等),根据空腹血糖四分位数将研究对象分为4组,Q1组(n=220):<5.00 mmol/L、Q2组(n=240):5.00~<5.40 mmol/L、Q3组(n=230):5.40~<5.81 mmol/L、Q4组(n=234):≥5.81 mmol/L。以功率车二级负荷试验作为有氧运动的形式,以baPWV水平作为反映四肢动脉僵硬度的指标,收集研究对象功率车二级负荷试验前、后baPWV相关资料〔SBP、DBP、平均动脉压(MAP)、心率(HR)和baPWV水平、代谢当量(MET)、最大摄氧量(VO2max)等〕,试验前记作1,试验后记作2;并计算前、后两次测量结果的差值(记作ΔbaPWV等)。比较Q1组、Q2组、Q3组、Q4组流行病学调查资料和baPWV相关资料的差异;采用广义线性回归模型评估不同血糖水平对功率车二级负荷试验前、后baPWV水平的影响。结果符合纳入标准的研究对象924例,平均年龄为(36.9±7.7)岁。各组流行病学调查资料比较结果显示,四组的年龄、高脂血症、高血压、降压药史、SBP、DBP、空腹血糖、超敏C反应蛋白、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇情况比较,差异有统计学意义(P<0.01);各组功率车二级负荷试验前�
Background Previous studies on the benefits of aerobic exercise mainly focus on the impact of aerobic exercise on long-term cardiovascular health and outcomes,namely regular aerobic exercise can improve arterial stiffness,while some studies point out that high blood sugar increases arterial stiffness.Objective To investigate the immediate effect of aerobic exercise on arterial stiffness in people with different blood glucose levels.Methods This study selected individuals who had participated in the 6th follow-up physical examination of the Kailuan Study during 2018—2020 and participated in the 5th national physical fitness surveillance in 2020 and completed their brachial-ankle pulse wave conduction velocity(baPWV)measured before and after the secondary load test of the power vehicle bicycle in four subordinate enterprises of Kailuan Group.Epidemiological survey result were collected:general information(age,hypertension,hyperlipidemia,history of antihypertensive drugs,etc.),anthropometric indicators〔systolic blood pressure(SBP),diastolic blood pressure(DBP),etc.〕and biochemical indicators(fasting blood glucose,etc.).baPWV measured in the secondary load test of the power vehicle bicycle(used as the aerobic exercise)was used as an indicator of upper and lower limb arterial stiffness.baPWVrelated indicators〔SBP,DBP,mean arterial pressure(MAP),heart rate(HR),baPWV,metabolic equivalent(MET),maximal oxygen uptake(VO2max),etc.〕before and after the test were expressed using a unified form,for example,preand post-test baPWV were recorded as baPWV1 and baPWV2,respectively,and its pre-and post-test difference was denoted asΔbaPWV.The epidemiological survey result and BAPWV-related data were compared between fasting blood glucose(FBG)quartile groups〔Q1(n=220):<5.00 mmol/L;Q2(n=240):5.00-<5.40 mmol/L;Q3(n=230):5.40-<5.81 mmol/L;Q4(n=234):≥5.81 mmol/L〕.Generalized linear regression model was used to evaluate the association of FBG with pre-and post-test baPWV.Results A total of 924 eligible cases were enrolled
作者
何荣
张丽
李鹏
张晓玲
张国
臧懿然
吴寿岭
孙丽霞
HE Rong;ZHANG Li;LI Peng;ZHANG Xiaoling;ZHANG Guo;ZANG Yiran;WU Shouling;SUN Lixia(Department of Emergency,North China University of Science and Technology Affiliated Hospital,Tangshan 063000,China;Graduate School of North China University of Science and Technology,Tangshan 063200,China;Department of Cardiology,Kailuan General Hospital,Tangshan 063000,China)
出处
《中国全科医学》
CAS
北大核心
2023年第24期2997-3004,共8页
Chinese General Practice
基金
河北省重点研发计划项目(19277791D)。
关键词
运动
糖尿病
血管硬化程度
有氧运动
血糖
动脉僵硬度
脉搏波传导速度
心血管疾病
Exercise
Diabetes mellitus
Vascular stiffness
Aerobic exercise
Fasting blood glucose
Arterial stiffness
Pulse wave velocity
Cardiovascular disease
