在查明凹凸棒石矿石矿物组成的基础上,系统采集明光市官山采矿场剖面样品,选择典型矿石样品,利用X射线衍射（XRD）、29Si魔角旋转核磁共振（29 Si MAS-NMR）对不同温度煅烧前后凹凸棒石结构研究,结合热重分析以及程序升温凹凸棒石脱水曲...在查明凹凸棒石矿石矿物组成的基础上,系统采集明光市官山采矿场剖面样品,选择典型矿石样品,利用X射线衍射（XRD）、29Si魔角旋转核磁共振（29 Si MAS-NMR）对不同温度煅烧前后凹凸棒石结构研究,结合热重分析以及程序升温凹凸棒石脱水曲线,认识热处理凹凸棒石结构演化规律,为凹凸棒石黏土加工和应用提供理论依据。结果表明：在240℃左右脱除结构中一半的结晶水,晶体结构发生调整,晶体内部孔道出现折叠;在430℃左右脱除另外二分之一结晶水,同时脱出晶体内部结构水和外表面结构水,晶体结构周期性基本破坏;凹凸棒石在500～700℃温度区间热处理后处于非晶化状态,但是c轴方向的部分有序性仍然存在,硅氧四面链尚没有解体;凹凸棒石脱出结构中一半的结晶水后,经过水化后可以恢复到原来的结构状态,超过350℃热处理凹凸棒石脱出更多的结构水后不能通过水化作用恢复到原来的结构状态。展开更多
OBJECTIVE; To observe the influence of Qingrehuatan decoction （QRHT） on serum metabolic profile in young essential hypertension （YEH） patients with abundant phlegm-heat syndrome and provide a basis for treatment w...OBJECTIVE; To observe the influence of Qingrehuatan decoction （QRHT） on serum metabolic profile in young essential hypertension （YEH） patients with abundant phlegm-heat syndrome and provide a basis for treatment with the decoction. METHODS： Twelve male YEH patients were randomly selected and serum samples were collected for examination before and after 4 weeks of thetreatment with QRHT. Twelve healthy males were randomly selected and their serum samples were collected as a control. All serum samples were detected using metabolomic technology with 1H nuclear magnetic resonance. Differences in metabo- lites were studied by principal component analysis and partial least squares-discriminate analysis, which produced scores and Ioadings plots.RESULTS： After 4 weeks of treatment, serum substances could be distinguished between the YEH patients with abundant phlegm-heat syndrome and the control patients. The specific serum endogenous metabolites tended to improve after the treatment. QRHT can appropriately increase the levels of glucose, lactic acid, citric acid, high-density lipoprotein, phosphatidylcholine, glycerophosphate choline, hydroxybutyrate, alanine, and glutamate. QRHT could also decrease the levels of low-density lipoprotein/very low-density lipoprotein, lipids, N-acetyl glycoprotein, and O-acetyl glycoprotein.CONCLUSION： QRHT can effectively ameliorate metabolic disorders in YEH Patients with abundant phlegmheat syndrome. 1H NMR-based metabolo- mic technology can provide an objective basis for the treatment of YEH patients with abundant phlegm-heat syndrome using QRHT.展开更多
We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational st...We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational study,we will include 15 LDH and 15 MPS.They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan(GV3).The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation,regional homogeneity analysis and brain functional connection.We select seed of first sensory cortex,second sensory cortex,insula cortex,periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data.Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion.展开更多
利用低场核磁共振技术(low-field nuclear magnetic resonance,LF-NMR),分析蚕豆内部的水分含量以及不同水分状态的变化规律。基于蚕豆传热传质数学模型,利用COMSOL Multiphysics软件对蚕豆的脱水过程进行了数值模拟。模拟0、4、8℃环...利用低场核磁共振技术(low-field nuclear magnetic resonance,LF-NMR),分析蚕豆内部的水分含量以及不同水分状态的变化规律。基于蚕豆传热传质数学模型,利用COMSOL Multiphysics软件对蚕豆的脱水过程进行了数值模拟。模拟0、4、8℃环境以及真空度为95、97、99 kPa条件下温度、压力对蚕豆脱水特性的影响,分析蚕豆不同位置点处的温度和水分分布规律。结果表明:蚕豆水含量与NMR信号幅值呈显著的线性关系,决定系数R^2=0.972,显著性水平P<0.01。在真空脱水过程中,自由水蒸发速度最快;半结合水含量呈增加-减少趋势,最终含量减少了88.5%;结合水含量仅有小幅度波动变化,最终含量减少了45.3%。真空压力的增大会促进水分蒸发,温度的增加会缩短脱水时间。展开更多
实验基于核磁共振技术(Nuclear Magnetic Resonance,NMR)检测的无损性,利用低场NMR技术测定热处理前后花旗松的纤维饱和点(Fiber Saturation Point,FSP).在-3℃和25℃条件下,对CPMG(Carr-Purcell-Meiboom-Gill)脉冲测得的信号进行横向...实验基于核磁共振技术(Nuclear Magnetic Resonance,NMR)检测的无损性,利用低场NMR技术测定热处理前后花旗松的纤维饱和点(Fiber Saturation Point,FSP).在-3℃和25℃条件下,对CPMG(Carr-Purcell-Meiboom-Gill)脉冲测得的信号进行横向弛豫时间(T_2)分析,对比试样冷冻前后信号反演峰面积,确定试样吸着水饱和含量,得到不同热处理条件下花旗松的纤维饱和点依次为38.76%(对照材)、32.82%(180℃热处理)、29.40%(200℃热处理)、24.90%(220℃热处理).实验结果表明,热处理温度越高,纤维饱和点越低.该结果测试结果与木材学理论相符,表明NMR技术可应用于快速确定木材纤维饱和点.展开更多
目的探讨多模态磁共振成像(M R I)联合血清人生长分化因子3(GDF3)、热休克蛋白-90α(HSP90A)诊断乳腺癌(BRCA)的临床价值。方法收集2017年1月-2020年12月间在本院健康检查后怀疑为BRCA的96例乳腺疾病患者作为研究对象。以术后病理或穿...目的探讨多模态磁共振成像(M R I)联合血清人生长分化因子3(GDF3)、热休克蛋白-90α(HSP90A)诊断乳腺癌(BRCA)的临床价值。方法收集2017年1月-2020年12月间在本院健康检查后怀疑为BRCA的96例乳腺疾病患者作为研究对象。以术后病理或穿刺活检结果为标准,将疑似患者分为BRCA组65例,良性组31例。所有受试者接受多模态MRI检查;酶联免疫吸附法检测血清GDF3、HSP90A水平,ROC和四表格分析多模态MRI、血清GDF3、HSP90A水平单独及联合诊断BRCA的价值。结果BRCA组Ktrans、Kep、MD显著高于良性组,ADCslow、ADCfast、MK均低于良性组(P<0.05);DCE-MRI、IVIM及DKI参数(Kep、ADCslow及MK值)诊断BRCA的AUC分别为0.724、0.730、0.652,DCEMRI+IVIM+DKI的诊断效能高于单一模型(Z=2.287~3.793,P=0.001~0.022),AUC为0.839。BRCA组血清GDF3、HSP90A水平均显著高于良性组(P<0.05);血清GDF3、HSP90A水平诊断BRCA的AUC为0.828、0.817,敏感度、70.77%、66.15%;特异度分别为83.87%、93.55%。多模态MRI联合血清GDF3、HSP90A检出假阳性6例,假阴性6例,Kappa值为0.714(P<0.05),与病理结果一致性较高,联合诊断BRCA的灵敏度、阴性预测值及准确度明显高于多模态MRI、血清GDF3、HSP90A单独诊断(P<0.05)。结论多模态MRI联合血清GDF3、HSP90A水平诊断BRCA具有较高的敏感度和准确度,具有一定临床应用价值。展开更多
目的研究磁共振成像(MRI)联合血清着丝粒结合蛋白U(CENPU)、热休克蛋白90α(HSP90α)在乳腺癌诊断中的临床价值。方法选取2021年1月至2023年4月在本院就诊的疑似乳腺癌患者227例进行研究,以术后病理诊断结果作为金标准,将227例疑似乳腺...目的研究磁共振成像(MRI)联合血清着丝粒结合蛋白U(CENPU)、热休克蛋白90α(HSP90α)在乳腺癌诊断中的临床价值。方法选取2021年1月至2023年4月在本院就诊的疑似乳腺癌患者227例进行研究,以术后病理诊断结果作为金标准,将227例疑似乳腺癌患者分为乳腺癌组143例,良性肿瘤组84例。对所有患者进行MRI检查,酶联免疫法检测血清HSP90α水平,qRT-PCR法检测血清CENPU水平。ROC曲线分析血清CENPU、HSP90α水平对乳腺癌的诊断价值,四表格法分析MRI检测及其联合血清CENPU、HSP90α水平对乳腺癌的诊断价值。结果乳腺癌组血清CENPU、HSP90α水平显著高于良性肿瘤组,差异具有统计学意义(P<0.05)。血清CENPU水平诊断乳腺癌的AUC为0.739,敏感性为65.73%,特异性为76.19%;HSP90α水平诊断乳腺癌的AUC为0.767,敏感性为79.72%,特异性为64.29%。MRI检查结果显示,乳腺癌患者137例,良性肿瘤患者90例;检出浸润性导管癌50例,乳腺导管内原位癌47例,乳头状瘤27例,浸润性小叶癌13例。MRI检查乳腺癌的敏感性为76.92%,特异性为67.86%,准确度为73.57%;MRI检查对乳腺癌的诊断结果与病理诊断结果具有一致性(Kappa值=0.441,P<0.05)。M R I联合血清C E N P U、HSP90α水平诊断乳腺癌的敏感性为98.60%,特异性为63.10%,准确度为85.46%;三者联合对乳腺癌的诊断结果与病理诊断结果具有较好一致性(Kappa=0.664,P<0.05);MRI联合血清CENPU、HSP90α水平诊断乳腺癌的敏感性和准确度显著高于MRI、CENPU、HSP90α单独诊断(P<0.05)。结论MRI联合血清CENPU、HSP90α对乳腺癌诊断具有重要临床价值。展开更多
文摘在查明凹凸棒石矿石矿物组成的基础上,系统采集明光市官山采矿场剖面样品,选择典型矿石样品,利用X射线衍射（XRD）、29Si魔角旋转核磁共振（29 Si MAS-NMR）对不同温度煅烧前后凹凸棒石结构研究,结合热重分析以及程序升温凹凸棒石脱水曲线,认识热处理凹凸棒石结构演化规律,为凹凸棒石黏土加工和应用提供理论依据。结果表明：在240℃左右脱除结构中一半的结晶水,晶体结构发生调整,晶体内部孔道出现折叠;在430℃左右脱除另外二分之一结晶水,同时脱出晶体内部结构水和外表面结构水,晶体结构周期性基本破坏;凹凸棒石在500～700℃温度区间热处理后处于非晶化状态,但是c轴方向的部分有序性仍然存在,硅氧四面链尚没有解体;凹凸棒石脱出结构中一半的结晶水后,经过水化后可以恢复到原来的结构状态,超过350℃热处理凹凸棒石脱出更多的结构水后不能通过水化作用恢复到原来的结构状态。
文摘OBJECTIVE; To observe the influence of Qingrehuatan decoction （QRHT） on serum metabolic profile in young essential hypertension （YEH） patients with abundant phlegm-heat syndrome and provide a basis for treatment with the decoction. METHODS： Twelve male YEH patients were randomly selected and serum samples were collected for examination before and after 4 weeks of thetreatment with QRHT. Twelve healthy males were randomly selected and their serum samples were collected as a control. All serum samples were detected using metabolomic technology with 1H nuclear magnetic resonance. Differences in metabo- lites were studied by principal component analysis and partial least squares-discriminate analysis, which produced scores and Ioadings plots.RESULTS： After 4 weeks of treatment, serum substances could be distinguished between the YEH patients with abundant phlegm-heat syndrome and the control patients. The specific serum endogenous metabolites tended to improve after the treatment. QRHT can appropriately increase the levels of glucose, lactic acid, citric acid, high-density lipoprotein, phosphatidylcholine, glycerophosphate choline, hydroxybutyrate, alanine, and glutamate. QRHT could also decrease the levels of low-density lipoprotein/very low-density lipoprotein, lipids, N-acetyl glycoprotein, and O-acetyl glycoprotein.CONCLUSION： QRHT can effectively ameliorate metabolic disorders in YEH Patients with abundant phlegmheat syndrome. 1H NMR-based metabolo- mic technology can provide an objective basis for the treatment of YEH patients with abundant phlegm-heat syndrome using QRHT.
基金Supported by Key Project of Jiangxi Provincial Youth Science Foundation:to Explore the Analgesic Mechanism of Brain Functional Network Regulation of moxibustion on Heat-sensitive Acupoints Based on rfMRI and MRS(No.20192ACB21007)Jiangxi Province Introduces and Cultivates Innovative and Entrepreneurial High-level Talent Projects:Brain Functional Network Regulation and Neurobiochemical Mechanism of Heat-sensitive Moxibustion Analgesia(No.jxsq2019201104)。
文摘We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational study,we will include 15 LDH and 15 MPS.They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan(GV3).The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation,regional homogeneity analysis and brain functional connection.We select seed of first sensory cortex,second sensory cortex,insula cortex,periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data.Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion.
文摘实验基于核磁共振技术(Nuclear Magnetic Resonance,NMR)检测的无损性,利用低场NMR技术测定热处理前后花旗松的纤维饱和点(Fiber Saturation Point,FSP).在-3℃和25℃条件下,对CPMG(Carr-Purcell-Meiboom-Gill)脉冲测得的信号进行横向弛豫时间(T_2)分析,对比试样冷冻前后信号反演峰面积,确定试样吸着水饱和含量,得到不同热处理条件下花旗松的纤维饱和点依次为38.76%(对照材)、32.82%(180℃热处理)、29.40%(200℃热处理)、24.90%(220℃热处理).实验结果表明,热处理温度越高,纤维饱和点越低.该结果测试结果与木材学理论相符,表明NMR技术可应用于快速确定木材纤维饱和点.
文摘目的探讨多模态磁共振成像(M R I)联合血清人生长分化因子3(GDF3)、热休克蛋白-90α(HSP90A)诊断乳腺癌(BRCA)的临床价值。方法收集2017年1月-2020年12月间在本院健康检查后怀疑为BRCA的96例乳腺疾病患者作为研究对象。以术后病理或穿刺活检结果为标准,将疑似患者分为BRCA组65例,良性组31例。所有受试者接受多模态MRI检查;酶联免疫吸附法检测血清GDF3、HSP90A水平,ROC和四表格分析多模态MRI、血清GDF3、HSP90A水平单独及联合诊断BRCA的价值。结果BRCA组Ktrans、Kep、MD显著高于良性组,ADCslow、ADCfast、MK均低于良性组(P<0.05);DCE-MRI、IVIM及DKI参数(Kep、ADCslow及MK值)诊断BRCA的AUC分别为0.724、0.730、0.652,DCEMRI+IVIM+DKI的诊断效能高于单一模型(Z=2.287~3.793,P=0.001~0.022),AUC为0.839。BRCA组血清GDF3、HSP90A水平均显著高于良性组(P<0.05);血清GDF3、HSP90A水平诊断BRCA的AUC为0.828、0.817,敏感度、70.77%、66.15%;特异度分别为83.87%、93.55%。多模态MRI联合血清GDF3、HSP90A检出假阳性6例,假阴性6例,Kappa值为0.714(P<0.05),与病理结果一致性较高,联合诊断BRCA的灵敏度、阴性预测值及准确度明显高于多模态MRI、血清GDF3、HSP90A单独诊断(P<0.05)。结论多模态MRI联合血清GDF3、HSP90A水平诊断BRCA具有较高的敏感度和准确度,具有一定临床应用价值。
文摘目的研究磁共振成像(MRI)联合血清着丝粒结合蛋白U(CENPU)、热休克蛋白90α(HSP90α)在乳腺癌诊断中的临床价值。方法选取2021年1月至2023年4月在本院就诊的疑似乳腺癌患者227例进行研究,以术后病理诊断结果作为金标准,将227例疑似乳腺癌患者分为乳腺癌组143例,良性肿瘤组84例。对所有患者进行MRI检查,酶联免疫法检测血清HSP90α水平,qRT-PCR法检测血清CENPU水平。ROC曲线分析血清CENPU、HSP90α水平对乳腺癌的诊断价值,四表格法分析MRI检测及其联合血清CENPU、HSP90α水平对乳腺癌的诊断价值。结果乳腺癌组血清CENPU、HSP90α水平显著高于良性肿瘤组,差异具有统计学意义(P<0.05)。血清CENPU水平诊断乳腺癌的AUC为0.739,敏感性为65.73%,特异性为76.19%;HSP90α水平诊断乳腺癌的AUC为0.767,敏感性为79.72%,特异性为64.29%。MRI检查结果显示,乳腺癌患者137例,良性肿瘤患者90例;检出浸润性导管癌50例,乳腺导管内原位癌47例,乳头状瘤27例,浸润性小叶癌13例。MRI检查乳腺癌的敏感性为76.92%,特异性为67.86%,准确度为73.57%;MRI检查对乳腺癌的诊断结果与病理诊断结果具有一致性(Kappa值=0.441,P<0.05)。M R I联合血清C E N P U、HSP90α水平诊断乳腺癌的敏感性为98.60%,特异性为63.10%,准确度为85.46%;三者联合对乳腺癌的诊断结果与病理诊断结果具有较好一致性(Kappa=0.664,P<0.05);MRI联合血清CENPU、HSP90α水平诊断乳腺癌的敏感性和准确度显著高于MRI、CENPU、HSP90α单独诊断(P<0.05)。结论MRI联合血清CENPU、HSP90α对乳腺癌诊断具有重要临床价值。
