摘要
目的研究磁共振成像(MRI)联合血清着丝粒结合蛋白U(CENPU)、热休克蛋白90α(HSP90α)在乳腺癌诊断中的临床价值。方法选取2021年1月至2023年4月在本院就诊的疑似乳腺癌患者227例进行研究,以术后病理诊断结果作为金标准,将227例疑似乳腺癌患者分为乳腺癌组143例,良性肿瘤组84例。对所有患者进行MRI检查,酶联免疫法检测血清HSP90α水平,qRT-PCR法检测血清CENPU水平。ROC曲线分析血清CENPU、HSP90α水平对乳腺癌的诊断价值,四表格法分析MRI检测及其联合血清CENPU、HSP90α水平对乳腺癌的诊断价值。结果乳腺癌组血清CENPU、HSP90α水平显著高于良性肿瘤组,差异具有统计学意义(P<0.05)。血清CENPU水平诊断乳腺癌的AUC为0.739,敏感性为65.73%,特异性为76.19%;HSP90α水平诊断乳腺癌的AUC为0.767,敏感性为79.72%,特异性为64.29%。MRI检查结果显示,乳腺癌患者137例,良性肿瘤患者90例;检出浸润性导管癌50例,乳腺导管内原位癌47例,乳头状瘤27例,浸润性小叶癌13例。MRI检查乳腺癌的敏感性为76.92%,特异性为67.86%,准确度为73.57%;MRI检查对乳腺癌的诊断结果与病理诊断结果具有一致性(Kappa值=0.441,P<0.05)。M R I联合血清C E N P U、HSP90α水平诊断乳腺癌的敏感性为98.60%,特异性为63.10%,准确度为85.46%;三者联合对乳腺癌的诊断结果与病理诊断结果具有较好一致性(Kappa=0.664,P<0.05);MRI联合血清CENPU、HSP90α水平诊断乳腺癌的敏感性和准确度显著高于MRI、CENPU、HSP90α单独诊断(P<0.05)。结论MRI联合血清CENPU、HSP90α对乳腺癌诊断具有重要临床价值。
Objective To study the clinical value of magnetic resonance imaging(MRI)combined with serum centromere protein U(CENPU)and heat shock protein 90α(HSP90α)in the diagnosis of breast cancer.Methods A total of 227 patients with suspected breast cancer who were hospitalized in our hospital from January 2021 to April 2023 were included for study,and 227 patients with suspected breast cancer were separated into 143 cases of breast cancer group and 84 cases of benign tumor group according to the results of postoperative pathological diagnosis as the gold standard.MRI examinations were performed on all patients,enzyme-linked immunosorbent assay was applied to detect serum HSP90αlevel,qRT-PCR method was applied to detect serum CENPU level.Receiver operating characteristic was applied to analyze the diagnostic value of serum CENPU and HSP90αlevels for breast cancer,the four Tabula recta method was applied to analyze the diagnostic value of MRI and its combination with serum CENPU and HSP90αlevels in breast cancer.Results The levels of serum CENPU and HSP90αin breast cancer group were obviously higher than those in benign tumor group(P<0.05).The AUC of serum CENPU level in diagnosis of breast cancer was 0.739,the sensitivity was 65.73%,and the specificity was 76.19%;the AUC of HSP90αlevel in diagnosis of breast cancer was 0.767,the sensitivity was 79.72%,and the specificity was 64.29%.MRI showed that 137 patients with breast cancer and 90 patients with benign tumor;50 cases of invasive ductal carcinoma,47 cases of breast ductal carcinoma in situ,27 cases of papilloma,and 13 cases of invasive lobular carcinoma were detected.The sensitivity,specificity and accuracy of MRI in breast cancer were 76.92%,67.86%and 73.57%respectively;the diagnosis result of MRI for breast cancer was consistent with that of pathology(Kappa value=0.441,P<0.05).The sensitivity,specificity and accuracy of MRI combined with serum CENPU and HSP90αlevels in the diagnosis of breast cancer were 98.60%,63.10%and 85.46%,respectively;the diagnosis resu
作者
邓菁
苏洁敏
黄文荣
DENG Jing;SU Jie-min;HUANG Wen-rong(Department of Radiology,Hainan Western Central Hospital,Danzhou 571700,Hainan Province,China)
出处
《中国CT和MRI杂志》
2024年第4期92-95,共4页
Chinese Journal of CT and MRI
