The activities of the catalytic hydrolysis of phosphate diester （BNPP） [bis（p-nitrophenyl）phosphate diester] and plasmid DNA （pUC 18） by mononuclear macrocyclic polyamine metal complexes have been investigated i...The activities of the catalytic hydrolysis of phosphate diester （BNPP） [bis（p-nitrophenyl）phosphate diester] and plasmid DNA （pUC 18） by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with le--Zn（II） complex （composed of lipophilic group） as catalyst. The hydrolysis rate enhancement is up to 3.64 × 10^4 fold. These metal complexes could effectively promote the cleavage of plasmid DNA （pUC18） at physiological conditions.展开更多
The first example of cyclodextrin dimer appending a macrocyclic polyamine spacer on the primary faces was synthesized via two approaches: 1, a direct reaction of 1,7-bis(2′-aminoethyl)-4,10-dimethyl-1,4,7,10-tetraaza...The first example of cyclodextrin dimer appending a macrocyclic polyamine spacer on the primary faces was synthesized via two approaches: 1, a direct reaction of 1,7-bis(2′-aminoethyl)-4,10-dimethyl-1,4,7,10-tetraazacyclododecane (1) with an excess of 6-deoxy-6-O-tosyl-β-cyclodextrin; 2, a condensation of 1 with two equivalents of 6-deoxy-6-formyl-β-cyclodextrin, which wan followed by a reduction with NaBH4.展开更多
Two fluorescent anion receptors (1 and 2) based on amide macrocycle were synthesized and corresponding fluorescence quenching induced by anion complexation was observed in different degree. Receptors form 1∶1 complex...Two fluorescent anion receptors (1 and 2) based on amide macrocycle were synthesized and corresponding fluorescence quenching induced by anion complexation was observed in different degree. Receptors form 1∶1 complexes with anions by hydrogen bonding interactions. Receptor 1 bound anions in the order of F->Cl->24HPO->CH3COO->>Br-, I- and receptor 2 showed high selectivity to F- over other anions.展开更多
Two novel cyclic polyamine derivatives bearing double aminoethyl groups have been synthesized. The synthetic intermediate, N-p-toluenesulfonyl-aziridine, was prepared employing an improved procedure.
A copper（Ⅱ） complex 1 of a novel macrocyclic polyamine ligand with hydroxylethyl pendant groups, 4,11-bis（hydroxylethyl）-5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane （L） has been synthesized and ...A copper（Ⅱ） complex 1 of a novel macrocyclic polyamine ligand with hydroxylethyl pendant groups, 4,11-bis（hydroxylethyl）-5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane （L） has been synthesized and characterized. Rate enhancement for hydrolysis of p-nitrophenyl picolinate （PNPP） catalyzed by 1 was studied kinetically under Brij35 micellar condition. For comparision, the catalytic activity of corresponding copper（Ⅱ） complex 2 of non-substituted macrocyclic polyamine ligand, 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraaza-cyclotetradecane （L＇） toward the hydrolysis of PNPP was also investigated. The results indicate that the macrocyclic polyamine copper（Ⅱ） complex 1 effectively catalyzed the hydrolysis of PNPP, and the pendant ligand hydroxyl group or deprotonated pendant ligand hydroxyl group can act as catalytically active species in the reaction. A ternary Complex kinetic model involving metal ion, ligand and substrate has been proposed, and the results confirmed the reasonability of such kinetic model.展开更多
Two new tetraamides bridged calix[4]arenes were synthesized by the condensation reaction of 1,3-bis-chlorocarbonylmethyl p-tert-butylcalix[4]arene with 1,2-bis (2′-amino-2′-methylpropanamido) benzene or 1,2-bis (2′...Two new tetraamides bridged calix[4]arenes were synthesized by the condensation reaction of 1,3-bis-chlorocarbonylmethyl p-tert-butylcalix[4]arene with 1,2-bis (2′-amino-2′-methylpropanamido) benzene or 1,2-bis (2′-amino-2′-methylpropanamido)-4,5-dichloro benzene, respectively. The new compounds were characterized by1H-NMR, MS-FAB, and elemental analysis; macrocyclic polyamine.展开更多
Macrocyctic tri- and tetra-amines containing a hydroxyl group in the ring have been prepared in moderate yields by a. 1:1 cyclocondensation of 1,3-dichloro-2-propanol with the disodium salt of N-tosylated diethylenetr...Macrocyctic tri- and tetra-amines containing a hydroxyl group in the ring have been prepared in moderate yields by a. 1:1 cyclocondensation of 1,3-dichloro-2-propanol with the disodium salt of N-tosylated diethylenetriamine and triethylenetetraamine. In the case of condensation of 1,3-dichoro-2-propanol with the disodium salt of N-tosylated diethylenetriamine, the 2:2 cyclocondensation product, dihydroxyl macrocyclic hexaamine, was also isolated.展开更多
Novel macrocyclic polyamine La(III) complexes have been synthesized.The hydrolysis of plasmid DNA(pUC18) by macrocyclic polyamine La(III) complexes has been investigated by using agarose gel electrophoresis method.The...Novel macrocyclic polyamine La(III) complexes have been synthesized.The hydrolysis of plasmid DNA(pUC18) by macrocyclic polyamine La(III) complexes has been investigated by using agarose gel electrophoresis method.The results indicated that these La(III) complexes could effectively promote the cleavage of plasmid DNA(pUC18) at physiological pH and temperature.展开更多
基金supported by the Science and Technology Department(No.04JY029-018)Education Department of Sichuan Province(No.2006ZD049).
文摘The activities of the catalytic hydrolysis of phosphate diester （BNPP） [bis（p-nitrophenyl）phosphate diester] and plasmid DNA （pUC 18） by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with le--Zn（II） complex （composed of lipophilic group） as catalyst. The hydrolysis rate enhancement is up to 3.64 × 10^4 fold. These metal complexes could effectively promote the cleavage of plasmid DNA （pUC18） at physiological conditions.
基金Project (29502010) supported by the National Natural Science Foundation of China
文摘The first example of cyclodextrin dimer appending a macrocyclic polyamine spacer on the primary faces was synthesized via two approaches: 1, a direct reaction of 1,7-bis(2′-aminoethyl)-4,10-dimethyl-1,4,7,10-tetraazacyclododecane (1) with an excess of 6-deoxy-6-O-tosyl-β-cyclodextrin; 2, a condensation of 1 with two equivalents of 6-deoxy-6-formyl-β-cyclodextrin, which wan followed by a reduction with NaBH4.
基金Project supported by the National Natural Science Foundation of China (No. 20372054).
文摘Two fluorescent anion receptors (1 and 2) based on amide macrocycle were synthesized and corresponding fluorescence quenching induced by anion complexation was observed in different degree. Receptors form 1∶1 complexes with anions by hydrogen bonding interactions. Receptor 1 bound anions in the order of F->Cl->24HPO->CH3COO->>Br-, I- and receptor 2 showed high selectivity to F- over other anions.
基金Project (No. 29502010) supported by the National Natural Science Foundation of China
文摘Two novel cyclic polyamine derivatives bearing double aminoethyl groups have been synthesized. The synthetic intermediate, N-p-toluenesulfonyl-aziridine, was prepared employing an improved procedure.
基金Project supporter by the National Natural Science Foundation of China （Nos. 20173038, 20107004）.
文摘A copper（Ⅱ） complex 1 of a novel macrocyclic polyamine ligand with hydroxylethyl pendant groups, 4,11-bis（hydroxylethyl）-5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane （L） has been synthesized and characterized. Rate enhancement for hydrolysis of p-nitrophenyl picolinate （PNPP） catalyzed by 1 was studied kinetically under Brij35 micellar condition. For comparision, the catalytic activity of corresponding copper（Ⅱ） complex 2 of non-substituted macrocyclic polyamine ligand, 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraaza-cyclotetradecane （L＇） toward the hydrolysis of PNPP was also investigated. The results indicate that the macrocyclic polyamine copper（Ⅱ） complex 1 effectively catalyzed the hydrolysis of PNPP, and the pendant ligand hydroxyl group or deprotonated pendant ligand hydroxyl group can act as catalytically active species in the reaction. A ternary Complex kinetic model involving metal ion, ligand and substrate has been proposed, and the results confirmed the reasonability of such kinetic model.
文摘Two new tetraamides bridged calix[4]arenes were synthesized by the condensation reaction of 1,3-bis-chlorocarbonylmethyl p-tert-butylcalix[4]arene with 1,2-bis (2′-amino-2′-methylpropanamido) benzene or 1,2-bis (2′-amino-2′-methylpropanamido)-4,5-dichloro benzene, respectively. The new compounds were characterized by1H-NMR, MS-FAB, and elemental analysis; macrocyclic polyamine.
基金Project (No. 29502010) supported by the National Natural Science Foundation of China
文摘Macrocyctic tri- and tetra-amines containing a hydroxyl group in the ring have been prepared in moderate yields by a. 1:1 cyclocondensation of 1,3-dichloro-2-propanol with the disodium salt of N-tosylated diethylenetriamine and triethylenetetraamine. In the case of condensation of 1,3-dichoro-2-propanol with the disodium salt of N-tosylated diethylenetriamine, the 2:2 cyclocondensation product, dihydroxyl macrocyclic hexaamine, was also isolated.
文摘Novel macrocyclic polyamine La(III) complexes have been synthesized.The hydrolysis of plasmid DNA(pUC18) by macrocyclic polyamine La(III) complexes has been investigated by using agarose gel electrophoresis method.The results indicated that these La(III) complexes could effectively promote the cleavage of plasmid DNA(pUC18) at physiological pH and temperature.
