Prostate and bladder cancers are one of the cancers occurring worldwide.In addition to radical surgery,the past decade has also focused on targeted therapy of overexpressed cancer proteins that are lethal and critical...Prostate and bladder cancers are one of the cancers occurring worldwide.In addition to radical surgery,the past decade has also focused on targeted therapy of overexpressed cancer proteins that are lethal and critical for cancer cell survival.However,targeted therapy cannot adapt for changing of cancer molecular characteristics and,ultimately,a clone that bypasses the targeted therapy emerges.This can be overcome by immunotherapy.New studies on ablative therapy of cancers show presence of immunomodulatory effect in these modalities.Tumor ablation prime the immune system for further destruction of persistent primary tumor in addition to destruction of concurrent metastatic disease and also reduce recurrence.Ablative therapies can achieve a state of increased antigenicity.Its combination with a novel macrophage targeted therapy may enhance immune priming,trafficking,and/or effector phases;thereby improving clinical outcomes.Tumor associated macrophages or M2 phenotype are now known to mediate this immunosuppressive pro-tumorigenic effect.Alteration of macrophage differentiation may enhance tumor destruction of ablative therapy.This breakthrough in immunotherapy opens up arenas for further robust clinical trials on combinatorial therapies.In the present review,we aim to elucidate the major aspects of immune stimulatory minimal invasive approaches by combining with macrophage directed pathways.展开更多
食品重金属污染日趋严重,为了证明LIBS快速检测大米中重金属元素含量的可行性,采用LIBS技术对经实验室含Cd溶液浸泡过的大米中Cd元素进行分析。首先采用LIBS和AAS技术,获取5个浓度系列的大米中Cd元素的LIBS光谱及真实浓度信息,再采用一...食品重金属污染日趋严重,为了证明LIBS快速检测大米中重金属元素含量的可行性,采用LIBS技术对经实验室含Cd溶液浸泡过的大米中Cd元素进行分析。首先采用LIBS和AAS技术,获取5个浓度系列的大米中Cd元素的LIBS光谱及真实浓度信息,再采用一元一次和一元二次定标分析模型,对Cd元素的特征光谱Cd II 214.4、Cd II226.5和Cd I 228.8进行定量分析。结果表明,原子谱线Cd I 228.8具有较高的线性相关性,并且一元二次回归模型具有较好的预测精度。试验结果表明,LIBS技术用于大米中重金属Cd元素的快速检测在理论和实践上具有可行性。展开更多
文摘Prostate and bladder cancers are one of the cancers occurring worldwide.In addition to radical surgery,the past decade has also focused on targeted therapy of overexpressed cancer proteins that are lethal and critical for cancer cell survival.However,targeted therapy cannot adapt for changing of cancer molecular characteristics and,ultimately,a clone that bypasses the targeted therapy emerges.This can be overcome by immunotherapy.New studies on ablative therapy of cancers show presence of immunomodulatory effect in these modalities.Tumor ablation prime the immune system for further destruction of persistent primary tumor in addition to destruction of concurrent metastatic disease and also reduce recurrence.Ablative therapies can achieve a state of increased antigenicity.Its combination with a novel macrophage targeted therapy may enhance immune priming,trafficking,and/or effector phases;thereby improving clinical outcomes.Tumor associated macrophages or M2 phenotype are now known to mediate this immunosuppressive pro-tumorigenic effect.Alteration of macrophage differentiation may enhance tumor destruction of ablative therapy.This breakthrough in immunotherapy opens up arenas for further robust clinical trials on combinatorial therapies.In the present review,we aim to elucidate the major aspects of immune stimulatory minimal invasive approaches by combining with macrophage directed pathways.
文摘食品重金属污染日趋严重,为了证明LIBS快速检测大米中重金属元素含量的可行性,采用LIBS技术对经实验室含Cd溶液浸泡过的大米中Cd元素进行分析。首先采用LIBS和AAS技术,获取5个浓度系列的大米中Cd元素的LIBS光谱及真实浓度信息,再采用一元一次和一元二次定标分析模型,对Cd元素的特征光谱Cd II 214.4、Cd II226.5和Cd I 228.8进行定量分析。结果表明,原子谱线Cd I 228.8具有较高的线性相关性,并且一元二次回归模型具有较好的预测精度。试验结果表明,LIBS技术用于大米中重金属Cd元素的快速检测在理论和实践上具有可行性。
