A coating of composition Si-40Mo (wt pct) was prepared by fused slurry coating method on the two-dimensional carbon/carbon (2D-C/C) composite to improve oxidation resistance. In the procedure of the fabrication, pure ...A coating of composition Si-40Mo (wt pct) was prepared by fused slurry coating method on the two-dimensional carbon/carbon (2D-C/C) composite to improve oxidation resistance. In the procedure of the fabrication, pure St slurry inner layer in the pre-coating was necessary to apply because of infiltration of liquid Si into the substrate during the sintering. The coating consists of Si continuous phase and MoSi2 particles. In addition, the infiltration of Si into the substrate and the SiC reaction layer between the coating and the C/C composite were observed. Oxidation behavior of coated and uncoated C/C composites was studied in cyclic mode. The oxidation resistance and the thermal shock resistance of the Si-Mo fused slurry coating were quite excellent at 1370℃.展开更多
Ferroptosis is a recently discovered pathway for regulated cell death pathway.However,its efficacy is affected by limited iron content and intracellular ion homeostasis.Here,we designed a metalorganic framework(MOF)-b...Ferroptosis is a recently discovered pathway for regulated cell death pathway.However,its efficacy is affected by limited iron content and intracellular ion homeostasis.Here,we designed a metalorganic framework(MOF)-based nanoplatform that incorporates calcium peroxide(CaO_(2))and oridonin(ORI).This platform can improve the tumor microenvironment and disrupt intracellular iron homeostasis,thereby enhancing ferroptosis therapy.Fused cell membranes(FM)were used to modify nanoparticles(ORI@CaO_(2)@Fe-TCPP,NPs)to produce FM@ORI@CaO_(2)@Fe-TCPP(FM@NPs).The encapsulated ORI inhibited the HSPB1/PCBP1/IREB2 and FSP1/COQ10 pathways simultaneously,working in tandem with Fe^(3+) to induce ferroptosis.Photodynamic therapy(PDT)guided by porphyrin(TCPP)significantly enhanced ferroptosis through excessive accumulation of reactive oxygen species(ROS).This selfamplifying strategy promoted robust ferroptosis,which could work synergistically with FM-mediated immunotherapy.In vivo experiments showed that FM@NPs inhibited 91.57%of melanoma cells within six days,a rate 5.6 times higher than chemotherapy alone.FM@NPs were biodegraded and directly eliminated in the urine or faeces without substantial toxicity.Thus,this study demonstrated that combining immunotherapy with efficient ferroptosis induction through nanotechnology is a feasible and promising strategy for melanoma treatment.展开更多
The mechanical properties of metal components are determined by the solidification behaviour and microstructure. A quantitative phase field model is used to investigate the microstructure evolution of fusedcoating add...The mechanical properties of metal components are determined by the solidification behaviour and microstructure. A quantitative phase field model is used to investigate the microstructure evolution of fusedcoating additive manufacturing, by which to improve the quality of deposition. During the fused-coating process, the molten metal in a crucible flows out of a nozzle and then reaches the substrate. The solidification happens at the moment when the molten metal comes into contact with substrate moving in three-dimensional space. The macroscopic heat transfer model of fused-coating is established to get the temperature field considered as the initial temperature boundary conditions in the phase field model. The numerical and experimental results show that the morphology of grains varies with different solidification environments. Columnar grains are observed during the early period at the bottom of fused-coating layer and the equiaxed grains appear subsequently ahead of the columnar grains. Columnar dendrites phase field simulations about the grains morphology and solute distribution are conducted considering the solidification environments. The simulation results are in good agreement with experimental results.展开更多
Benefitting from low cost and simple synthesis,simple structured non-fused ring acceptors(NFRAs)and polymer donors are crucial for the application of organic solar cells(OSCs).Herein,two isomerized NFRAs,namely 4T-FCl...Benefitting from low cost and simple synthesis,simple structured non-fused ring acceptors(NFRAs)and polymer donors are crucial for the application of organic solar cells(OSCs).Herein,two isomerized NFRAs,namely 4T-FCl FCl and 4T-2F2Cl,are designed with end-group engineering,which modulates the electrostatic potential distributions and crystallinity of acceptors,and accordingly,the A/A and D/A intermolecular interactions.The OSC based on 4T-2F2Cl with strong D/A interactions shows a record-high efficiency of 16.31%in blending with a low-cost polymer donor PTQ10,which shapes obviously improved bulkheterojunction(BHJ)networks blade-coated by non-halogenated solvent o-xylene,and thus significantly diminishes nonradiative recombination loss.A higher industrial figure of merit(i-FOM)of 0.46 for PTQ10:4T-2F2Cl in comparison with PTQ10:4T-FCl FCl(i-FOM=0.29)is demonstrated owing to its superior device efficiency and operational stability.Note that the i-FOM of PTQ10:4T-2F2Cl is the highest value for OSCs reported so far.This work deepens the synergistic effect of the A/A and D/A interactions on achieving desired bulk heterojunction morphology and demonstrates a printable photovoltaic system for low-cost,high-efficiency,stable,and eco-friendly OSCs.展开更多
文摘A coating of composition Si-40Mo (wt pct) was prepared by fused slurry coating method on the two-dimensional carbon/carbon (2D-C/C) composite to improve oxidation resistance. In the procedure of the fabrication, pure St slurry inner layer in the pre-coating was necessary to apply because of infiltration of liquid Si into the substrate during the sintering. The coating consists of Si continuous phase and MoSi2 particles. In addition, the infiltration of Si into the substrate and the SiC reaction layer between the coating and the C/C composite were observed. Oxidation behavior of coated and uncoated C/C composites was studied in cyclic mode. The oxidation resistance and the thermal shock resistance of the Si-Mo fused slurry coating were quite excellent at 1370℃.
基金the Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(No.CACM-QNRC2-A03,China)the Beijing Natural Science Foundation(No.7202121,China)the National Natural Science Foundation of China(No.81703715).
文摘Ferroptosis is a recently discovered pathway for regulated cell death pathway.However,its efficacy is affected by limited iron content and intracellular ion homeostasis.Here,we designed a metalorganic framework(MOF)-based nanoplatform that incorporates calcium peroxide(CaO_(2))and oridonin(ORI).This platform can improve the tumor microenvironment and disrupt intracellular iron homeostasis,thereby enhancing ferroptosis therapy.Fused cell membranes(FM)were used to modify nanoparticles(ORI@CaO_(2)@Fe-TCPP,NPs)to produce FM@ORI@CaO_(2)@Fe-TCPP(FM@NPs).The encapsulated ORI inhibited the HSPB1/PCBP1/IREB2 and FSP1/COQ10 pathways simultaneously,working in tandem with Fe^(3+) to induce ferroptosis.Photodynamic therapy(PDT)guided by porphyrin(TCPP)significantly enhanced ferroptosis through excessive accumulation of reactive oxygen species(ROS).This selfamplifying strategy promoted robust ferroptosis,which could work synergistically with FM-mediated immunotherapy.In vivo experiments showed that FM@NPs inhibited 91.57%of melanoma cells within six days,a rate 5.6 times higher than chemotherapy alone.FM@NPs were biodegraded and directly eliminated in the urine or faeces without substantial toxicity.Thus,this study demonstrated that combining immunotherapy with efficient ferroptosis induction through nanotechnology is a feasible and promising strategy for melanoma treatment.
基金supported by the National Key R&D Program(2016YFB1100400)the Ministry of Education,China(6141A02022109)
文摘The mechanical properties of metal components are determined by the solidification behaviour and microstructure. A quantitative phase field model is used to investigate the microstructure evolution of fusedcoating additive manufacturing, by which to improve the quality of deposition. During the fused-coating process, the molten metal in a crucible flows out of a nozzle and then reaches the substrate. The solidification happens at the moment when the molten metal comes into contact with substrate moving in three-dimensional space. The macroscopic heat transfer model of fused-coating is established to get the temperature field considered as the initial temperature boundary conditions in the phase field model. The numerical and experimental results show that the morphology of grains varies with different solidification environments. Columnar grains are observed during the early period at the bottom of fused-coating layer and the equiaxed grains appear subsequently ahead of the columnar grains. Columnar dendrites phase field simulations about the grains morphology and solute distribution are conducted considering the solidification environments. The simulation results are in good agreement with experimental results.
基金supported by the National Natural Science Foundation of China(52061135206,22279094)the Fundamental Research Funds for the Central Universities。
文摘Benefitting from low cost and simple synthesis,simple structured non-fused ring acceptors(NFRAs)and polymer donors are crucial for the application of organic solar cells(OSCs).Herein,two isomerized NFRAs,namely 4T-FCl FCl and 4T-2F2Cl,are designed with end-group engineering,which modulates the electrostatic potential distributions and crystallinity of acceptors,and accordingly,the A/A and D/A intermolecular interactions.The OSC based on 4T-2F2Cl with strong D/A interactions shows a record-high efficiency of 16.31%in blending with a low-cost polymer donor PTQ10,which shapes obviously improved bulkheterojunction(BHJ)networks blade-coated by non-halogenated solvent o-xylene,and thus significantly diminishes nonradiative recombination loss.A higher industrial figure of merit(i-FOM)of 0.46 for PTQ10:4T-2F2Cl in comparison with PTQ10:4T-FCl FCl(i-FOM=0.29)is demonstrated owing to its superior device efficiency and operational stability.Note that the i-FOM of PTQ10:4T-2F2Cl is the highest value for OSCs reported so far.This work deepens the synergistic effect of the A/A and D/A interactions on achieving desired bulk heterojunction morphology and demonstrates a printable photovoltaic system for low-cost,high-efficiency,stable,and eco-friendly OSCs.
