Recent progress in bioinorganic chemistry studies of rare earth elements (REE) in animal cells was outlined, and the definition of REE′s biological intelligence as well as their mechanism were also explained. The mig...Recent progress in bioinorganic chemistry studies of rare earth elements (REE) in animal cells was outlined, and the definition of REE′s biological intelligence as well as their mechanism were also explained. The migration of REE from weathering rocks to the environment is accelerated by various anthropogenic activities, which can eventually result in the entrance of REE into animal and human bodies via food chain. REE can be found in body tissues such as brain, blood, muscle as well as bone. Based on their geochemical properties, REE in low dose show their unique biological intelligence by intervening in the process of signal transduction and its regulation, arteriosclerosis and blood clotting prevention, anticancer, and the promotion of cellular defense enzymes′ activities, nucleic acid metabolism enzymes as well as ATPases, etc. The meaning of REE′s biological intelligence refers to physicochemical properties-based capability to choose the targets (e.g., biometals) in biomolecules for the chelation or replacement of REE, and change the structures and functions of biomolecules, and consequently impact or control the biological functions or behaviors in living organisms. The regulation of various cellular processes caused by REE is mainly via antagonism or replacement of essential target biometals like calcium or via chelation of organic molecules, thereby embodying the unparalleled biological intelligence of REE. Additionally, the dosage effect of REE was also discussed from the angles of yin-yang dichotomy, bioavailability, entropy and evolution. In order to make full use of REE′s biological intelligence in the application for medicine, more detailed studies concerning dosage effect of REE and REE bioaccumulation in organisms should be conducted in future research.展开更多
目的:分析所有miR-223基因家族成员的序列特征,并对miR-223靶基因进行预测,然后分析miR-223靶基因的生物学功能。方法:利用Clustal X 1.83软件分析miR-223基因序列特征,MEGA 5.0软件分析进化关系,再运用TargetScan、PicTar和miRDB进行...目的:分析所有miR-223基因家族成员的序列特征,并对miR-223靶基因进行预测,然后分析miR-223靶基因的生物学功能。方法:利用Clustal X 1.83软件分析miR-223基因序列特征,MEGA 5.0软件分析进化关系,再运用TargetScan、PicTar和miRDB进行靶基因预测,最后GO和KEGG进行功能分析。结果:在miRBase数据中获得miRNA-223基因家族成员的序列27条,绝大部分位于基因间隔区,少数成员的基因位置未知。大部分定位于X染色体,部分成员位于常染色体。miRNA-223成熟序列长度在20-23nt之间,同源性较高。系统进化树分析表明,miRNA-223基因家族成员分为三支。预测获得人类miRNA-223的可能具有27个靶基因,它们主要与信号转导、转录调控以及细胞生长发育等密切相关。结论:本研究结果不仅有利于理解miR-223基因家族的生物学功能,也可为后续研究提供理论依据。展开更多
文摘Recent progress in bioinorganic chemistry studies of rare earth elements (REE) in animal cells was outlined, and the definition of REE′s biological intelligence as well as their mechanism were also explained. The migration of REE from weathering rocks to the environment is accelerated by various anthropogenic activities, which can eventually result in the entrance of REE into animal and human bodies via food chain. REE can be found in body tissues such as brain, blood, muscle as well as bone. Based on their geochemical properties, REE in low dose show their unique biological intelligence by intervening in the process of signal transduction and its regulation, arteriosclerosis and blood clotting prevention, anticancer, and the promotion of cellular defense enzymes′ activities, nucleic acid metabolism enzymes as well as ATPases, etc. The meaning of REE′s biological intelligence refers to physicochemical properties-based capability to choose the targets (e.g., biometals) in biomolecules for the chelation or replacement of REE, and change the structures and functions of biomolecules, and consequently impact or control the biological functions or behaviors in living organisms. The regulation of various cellular processes caused by REE is mainly via antagonism or replacement of essential target biometals like calcium or via chelation of organic molecules, thereby embodying the unparalleled biological intelligence of REE. Additionally, the dosage effect of REE was also discussed from the angles of yin-yang dichotomy, bioavailability, entropy and evolution. In order to make full use of REE′s biological intelligence in the application for medicine, more detailed studies concerning dosage effect of REE and REE bioaccumulation in organisms should be conducted in future research.
文摘目的:分析所有miR-223基因家族成员的序列特征,并对miR-223靶基因进行预测,然后分析miR-223靶基因的生物学功能。方法:利用Clustal X 1.83软件分析miR-223基因序列特征,MEGA 5.0软件分析进化关系,再运用TargetScan、PicTar和miRDB进行靶基因预测,最后GO和KEGG进行功能分析。结果:在miRBase数据中获得miRNA-223基因家族成员的序列27条,绝大部分位于基因间隔区,少数成员的基因位置未知。大部分定位于X染色体,部分成员位于常染色体。miRNA-223成熟序列长度在20-23nt之间,同源性较高。系统进化树分析表明,miRNA-223基因家族成员分为三支。预测获得人类miRNA-223的可能具有27个靶基因,它们主要与信号转导、转录调控以及细胞生长发育等密切相关。结论:本研究结果不仅有利于理解miR-223基因家族的生物学功能,也可为后续研究提供理论依据。
