发育性癫痫性脑病(developmental and epileptic encephalopathy,DEE)是一组以耐药性癫痫和神经发育迟缓为特征的异质性疾病,可阻碍患儿大脑发育,导致严重的认知、行为和运动障碍。DEE患儿多数在婴幼儿期起病,主要由遗传因素导致,总体...发育性癫痫性脑病(developmental and epileptic encephalopathy,DEE)是一组以耐药性癫痫和神经发育迟缓为特征的异质性疾病,可阻碍患儿大脑发育,导致严重的认知、行为和运动障碍。DEE患儿多数在婴幼儿期起病,主要由遗传因素导致,总体预后较差。本文对DEE的概念、相关癫痫综合征、遗传学病因以及精准治疗等方面的研究进行述评。展开更多
Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in ...Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in epileptic patients has not been certified because of insufficient supportive evidence. This insufficient supportive evidence stems from the fact that most of the current studies regarding TCHM for epilepsy treatment are not designed according to the different seizure types and epileptic syndromes (STESs). Here, we explore the reasons why many studies have not considered the various STESs and explain how to treat epilepsy according to the pharmacological mechanism for different STESs and exploit the advantage of TCHM for epilepsy treatment. Then, we explain how we treat epilepsy using TCHM according to the different STESs and Bian Zheng Lun Zi.展开更多
文摘发育性癫痫性脑病(developmental and epileptic encephalopathy,DEE)是一组以耐药性癫痫和神经发育迟缓为特征的异质性疾病,可阻碍患儿大脑发育,导致严重的认知、行为和运动障碍。DEE患儿多数在婴幼儿期起病,主要由遗传因素导致,总体预后较差。本文对DEE的概念、相关癫痫综合征、遗传学病因以及精准治疗等方面的研究进行述评。
文摘Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in epileptic patients has not been certified because of insufficient supportive evidence. This insufficient supportive evidence stems from the fact that most of the current studies regarding TCHM for epilepsy treatment are not designed according to the different seizure types and epileptic syndromes (STESs). Here, we explore the reasons why many studies have not considered the various STESs and explain how to treat epilepsy according to the pharmacological mechanism for different STESs and exploit the advantage of TCHM for epilepsy treatment. Then, we explain how we treat epilepsy using TCHM according to the different STESs and Bian Zheng Lun Zi.
