摘要
目的观察小剂量促肾上腺皮质激素(ACTH)联合硝西泮治疗West综合征的疗效。方法对42例West综合征采用小剂量ACTH微量输液泵泵入方法,同时口服硝西泮治疗,对其疗效进行总结、随访。结果完全控制28例,占66.7%;显效4例,占9.53%;有效5例,占11.90%;无效5例,占11.90%,总有效率88.10%。完全控制病例随访3mo时均无发作,其中3例随访3a、1例随访5a一直未见痉挛发作,也未转型,智力、运动发育无明显落后;5例于发作控制1a后转为强直-阵挛发作或不典型失神发作。9例显效、有效病例在泼尼松维护治疗过程中,2例发作控制,未转型;3例转为强直-阵挛发作;另4例失访。5例无效病例,后均转为其他类型发作。用药过程中少部分病例出现轻度血压升高、上呼吸道感染、轻度电解质紊乱等不良反应,无严重不良反应发生。结论采用小剂量ACTH微量输液泵泵入联合硝西泮治疗West综合征疗效满意,尤其短期疗效明显,优于单一用药,且不良反应少,患儿耐受性良好。
AIM To observe the efficacy of adrenocorticotropic hormone（ACrH） and nitrozepam in treatmert of West syndrome. METHODS Forty-two patients with West syndrome were treated with small dose of ACTH（20 U ACTH to 5% or 10% GS and at the speed of 10 mL·h^- 1 daily for 2 wk） combining with taking nitrozepam （0.1 - 0.5 mg·kg^- 1 ·d^- 1 ） orally at the same time. The effectiveness and adverse drug reactions were observed. RESULTS Twenty eight patients were controlled completely;Nine patients were controlled effectively. The total effective rate was 88.09 %. After two weeks treatment with ACTH, a few of patients showed the adverse drug reactions of hypertension, infection of respiratory tract, disorder of electrolyte, mild atrophy of brain, without any severe adverse drug reactions. CONCLUSION The patients with West syndrome are treated with small dose of ACTH combining with taking nitrozepam orally shows good outcome in short-term.
出处
《中国临床药学杂志》
CAS
2006年第5期312-314,共3页
Chinese Journal of Clinical Pharmacy
