Background：Orthotopic liver transplantation （OLT） improves the prognosis of patients with hepatocellular carcinoma （HCC）.Moreover,the complement system is a powerful immune effector that can affect liver function...Background：Orthotopic liver transplantation （OLT） improves the prognosis of patients with hepatocellular carcinoma （HCC）.Moreover,the complement system is a powerful immune effector that can affect liver function and process of liver cirrhosis.However,studies correlating the complement system with tacrolimus metabolism after OLT are scarce.In this study,the role of single nucleotide polymorphisms （SNPs） associated with the sixth complement component （C6） in tacrolimus metabolism was investigated during the early stages of liver transplantation.Methods：The study enrolled 135 adult patients treated with OLT for HCC between August 2011 and October 2013.Ten SNPs in C6 gene and rs776746 in cytochrome P450 3A5 （CYP3A5） gene were investigated.The tacrolilnus levels were monitored daily during 4 weeks after transplantation.Results：Both donor and recipient CYP3A5 rs776746 allele A were correlated with decreased concentration/dose （C/D） ratios.Recipient C6 rs9200 allele G and donor C6 rs10052999 homozygotes were correlated with lower C/D ratios.Recipient CYP3A5 rs776746 allele A （yielded median tacrolimus C/D ratios of 225.90 at week 1 and 123.61 at week 2）,C6 rs9200 allele G （exhibited median tacrolimus C/D ratios of 211.31 at week l,110.23 at week 2,and 99.88 at week 3）,and donor CYP3A5 rs776746 allele A （exhibited median C/D ratios of 210.82 at week l,111.06 at week 2,77.49 at week 3,and 85.60 at week 4） and C6 rs 10052999 homozygote （exhibited median C/D ratios of 167.59 at week 2,157.99 at week 3,and 155.36 at week 4） were associated with rapid tacrolimus metabolism.With increasing number of these alleles,patients were found to have lower tacrolimus C/D ratios at various time points during the 4 weeks after transplantation.In multiple linear regression analysis,recipient C6 rs9200 group （AA vs.GG/GA） was found to be related to tacrolimus metabolism at weeks 1,2,and 3 （P =0.005,P =0.045,and P =0.033,respectively）,whereas donor C6 rs10052999 group （CC/TT vs.TC） w展开更多
The development of a pseudo-one pot synthesis of 3（5）,4-dinitropyrazole enabled us to use it as a starting material for energetic plasticisers. Its acidic proton allowed simple derivatisation on one of the ring nitr...The development of a pseudo-one pot synthesis of 3（5）,4-dinitropyrazole enabled us to use it as a starting material for energetic plasticisers. Its acidic proton allowed simple derivatisation on one of the ring nitrogens. The thermal characteristics of two derivatives were evaluated. For instance, the N-allyl compound was a liquid with very low glass transition temperature, whereas the N-propargyl compound was a sticky solid at ambient temperature. The two compounds were both thermally stable according to STANAG 4582.展开更多
Mid-infrared（MIR） emissions of 2.4 and 3.5 μm from Tm3＋：LiYF4 single crystals attributed to3H4 →3H5 and3H5 →3F4 transitions as well as MIR emissions of 4.2,4.3,and 4.5 μm from Nd3＋：LiYF4 lasers attributed to...Mid-infrared（MIR） emissions of 2.4 and 3.5 μm from Tm3＋：LiYF4 single crystals attributed to3H4 →3H5 and3H5 →3F4 transitions as well as MIR emissions of 4.2,4.3,and 4.5 μm from Nd3＋：LiYF4 lasers attributed to4I15/2 →4I13/2,4I13/2 →4I11/2,and4I11/2 →4I9/2 transitions,respectively,are observed.LiYF4 single crystals possess high transmittance of over 85% in the 2.5-6 μm range.The large emission crosssections of Tm-doped crystals at 2.4 μm（1.9×10-20cm2） and Nd-doped crystals at 4.2 μm（0.84×10-20 cm2） as well as the high rare-earth doping concentrations,excellent optical transmission,and chemicalphysical properties of the resultant samples indicate that Nd3＋and Tm3＋singly doped crystals may be promising materials for application in MIR lasers.展开更多
基金This study was supported by grants from the National Natural Science Foundation of China （No. 81370579） and the Science and Technology Commission of Shanghai Municipality, China （No. 134119a6300）.
文摘Background：Orthotopic liver transplantation （OLT） improves the prognosis of patients with hepatocellular carcinoma （HCC）.Moreover,the complement system is a powerful immune effector that can affect liver function and process of liver cirrhosis.However,studies correlating the complement system with tacrolimus metabolism after OLT are scarce.In this study,the role of single nucleotide polymorphisms （SNPs） associated with the sixth complement component （C6） in tacrolimus metabolism was investigated during the early stages of liver transplantation.Methods：The study enrolled 135 adult patients treated with OLT for HCC between August 2011 and October 2013.Ten SNPs in C6 gene and rs776746 in cytochrome P450 3A5 （CYP3A5） gene were investigated.The tacrolilnus levels were monitored daily during 4 weeks after transplantation.Results：Both donor and recipient CYP3A5 rs776746 allele A were correlated with decreased concentration/dose （C/D） ratios.Recipient C6 rs9200 allele G and donor C6 rs10052999 homozygotes were correlated with lower C/D ratios.Recipient CYP3A5 rs776746 allele A （yielded median tacrolimus C/D ratios of 225.90 at week 1 and 123.61 at week 2）,C6 rs9200 allele G （exhibited median tacrolimus C/D ratios of 211.31 at week l,110.23 at week 2,and 99.88 at week 3）,and donor CYP3A5 rs776746 allele A （exhibited median C/D ratios of 210.82 at week l,111.06 at week 2,77.49 at week 3,and 85.60 at week 4） and C6 rs 10052999 homozygote （exhibited median C/D ratios of 167.59 at week 2,157.99 at week 3,and 155.36 at week 4） were associated with rapid tacrolimus metabolism.With increasing number of these alleles,patients were found to have lower tacrolimus C/D ratios at various time points during the 4 weeks after transplantation.In multiple linear regression analysis,recipient C6 rs9200 group （AA vs.GG/GA） was found to be related to tacrolimus metabolism at weeks 1,2,and 3 （P =0.005,P =0.045,and P =0.033,respectively）,whereas donor C6 rs10052999 group （CC/TT vs.TC） w
文摘The development of a pseudo-one pot synthesis of 3（5）,4-dinitropyrazole enabled us to use it as a starting material for energetic plasticisers. Its acidic proton allowed simple derivatisation on one of the ring nitrogens. The thermal characteristics of two derivatives were evaluated. For instance, the N-allyl compound was a liquid with very low glass transition temperature, whereas the N-propargyl compound was a sticky solid at ambient temperature. The two compounds were both thermally stable according to STANAG 4582.
基金supported by the National Natural Science Foundation of China(Nos.51272109 and 50972061)the Natural Science Foundation of Zhejiang Province(No.R4100364)+1 种基金the Natural Science Foundation of Ningbo City(No.2012A610115)the K.C.Wong Magna Fund in Ningbo University
文摘Mid-infrared（MIR） emissions of 2.4 and 3.5 μm from Tm3＋：LiYF4 single crystals attributed to3H4 →3H5 and3H5 →3F4 transitions as well as MIR emissions of 4.2,4.3,and 4.5 μm from Nd3＋：LiYF4 lasers attributed to4I15/2 →4I13/2,4I13/2 →4I11/2,and4I11/2 →4I9/2 transitions,respectively,are observed.LiYF4 single crystals possess high transmittance of over 85% in the 2.5-6 μm range.The large emission crosssections of Tm-doped crystals at 2.4 μm（1.9×10-20cm2） and Nd-doped crystals at 4.2 μm（0.84×10-20 cm2） as well as the high rare-earth doping concentrations,excellent optical transmission,and chemicalphysical properties of the resultant samples indicate that Nd3＋and Tm3＋singly doped crystals may be promising materials for application in MIR lasers.
