目的探讨高脂血症、高糖血症、高尿酸血症等心血管疾病危险因素与冠心病和高血压病的相关关系。方法用O-lympus AU 400全自动生化分析仪检测127例冠心病、89例原发性高血压和106例冠心病与原发性高血压并存患者及120例健康对照者血清总...目的探讨高脂血症、高糖血症、高尿酸血症等心血管疾病危险因素与冠心病和高血压病的相关关系。方法用O-lympus AU 400全自动生化分析仪检测127例冠心病、89例原发性高血压和106例冠心病与原发性高血压并存患者及120例健康对照者血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、血糖（Glu）和尿酸（UA）浓度。结果冠心病、原发性高血压、冠心病与原发性高血压并存患者TC、TG、LDL-C、Glu和UA水平均明显比健康对照组高（F=7．32～22．59，P〈0．05），而HDL-C却比对照组低（F=8．33，P〈0．01）。高胆固醇血症、高甘油三脂血症、高糖血症和高尿酸血症4种心血管疾病危险因素累积在冠心病、原发性高血压和冠心病与原发性高血压并存患者的检出率分别为52．73％、46．07％和58．49％。结论高脂血症、高糖血症和高尿酸血症与冠心病和原发性高血压之间存在密切联系，脂代谢紊乱、糖尿病和高尿酸血症交互影响，促进心血管疾病的发生和发展。展开更多
Background: Guidelines are issued by most major organizations that focus on a specific disease entity. Guidelines should be a significant help to the practicing physician who may not be up-to-date with the recent medi...Background: Guidelines are issued by most major organizations that focus on a specific disease entity. Guidelines should be a significant help to the practicing physician who may not be up-to-date with the recent medical literature. Unfortunately, when conflicting guidelines for a specific disease are published, confusion results. Purpose: This article provides a suggested guideline outcome measure that would benefit the physician and patient. Methods: A review of 19 different guidelines for cardiovascular disease treatment is one example of the lack of specific outcomes that currently exist. The basic problem with most guidelines is that they do not state the expected end result (i.e., the benefit to the patient) if that guideline is followed. When guidelines use cardiovascular disease risk factors to dictate therapy, the end benefit is never stated so that the patient can make an appropriate choice of which (if any) guideline to follow. Results: A good example is guidelines published by the American Heart Association for reducing cardiovascular disease. These guidelines are risk factor based and only indicate that cardiovascular disease would be reduced if followed. No specific percentage in the reduction of the incidence of disease is given. In contrast, when elimination of the disease is the stated goal of the guideline, the end result is clear. To date, this goal has been stated by only one organization devoted to eliminating cardiovascular disease. Conclusion: Guidelines need to be written to provide the physician and the patient with a specific end point that is expected when the guideline is followed. Patient acceptance and compliance will be much improved if the patient knows the risk/benefit of following the guideline’s recommendations.展开更多
目的:综合评价同期训练对心血管疾病风险因素的干预效果。方法:通过Web of Science、EBSCO、PubMed、Medline、EMBASE、中国知网(CNKI)等数据库检索自建库至2023年6月30日的相关文献,采用Review Manager 5.4软件进行Meta分析,以PEDro量...目的:综合评价同期训练对心血管疾病风险因素的干预效果。方法:通过Web of Science、EBSCO、PubMed、Medline、EMBASE、中国知网(CNKI)等数据库检索自建库至2023年6月30日的相关文献,采用Review Manager 5.4软件进行Meta分析,以PEDro量表评价文献质量。共纳入19项研究,涉及921例样本。PEDro量表评分有13篇文献评价为6~8分,6篇文献评价为4~5分,平均值为6分,总体方法学质量较高。结果:同期训练组与对照组相比,对于受试者的收缩压与舒张压的改善虽仅有较小的效应量,但结果仍有显著的改善效果;同期训练能够显著地改善受试者的甘油三酯、总胆固醇,并呈现出小到中等的效应量,但对血糖没有显著影响;同期训练对受试者最大摄氧量有中等程度的改善,且具有非常显著性影响。结论:同期训练能够有效改善受试者的血压(收缩压和舒张压)、最大摄氧量、胆固醇和甘油三酯水平,但对于血糖并未产生积极影响;同期训练对于心血管疾病的预防和改善是一种有效的方法。展开更多
文摘目的探讨高脂血症、高糖血症、高尿酸血症等心血管疾病危险因素与冠心病和高血压病的相关关系。方法用O-lympus AU 400全自动生化分析仪检测127例冠心病、89例原发性高血压和106例冠心病与原发性高血压并存患者及120例健康对照者血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、血糖（Glu）和尿酸（UA）浓度。结果冠心病、原发性高血压、冠心病与原发性高血压并存患者TC、TG、LDL-C、Glu和UA水平均明显比健康对照组高（F=7．32～22．59，P〈0．05），而HDL-C却比对照组低（F=8．33，P〈0．01）。高胆固醇血症、高甘油三脂血症、高糖血症和高尿酸血症4种心血管疾病危险因素累积在冠心病、原发性高血压和冠心病与原发性高血压并存患者的检出率分别为52．73％、46．07％和58．49％。结论高脂血症、高糖血症和高尿酸血症与冠心病和原发性高血压之间存在密切联系，脂代谢紊乱、糖尿病和高尿酸血症交互影响，促进心血管疾病的发生和发展。
文摘Background: Guidelines are issued by most major organizations that focus on a specific disease entity. Guidelines should be a significant help to the practicing physician who may not be up-to-date with the recent medical literature. Unfortunately, when conflicting guidelines for a specific disease are published, confusion results. Purpose: This article provides a suggested guideline outcome measure that would benefit the physician and patient. Methods: A review of 19 different guidelines for cardiovascular disease treatment is one example of the lack of specific outcomes that currently exist. The basic problem with most guidelines is that they do not state the expected end result (i.e., the benefit to the patient) if that guideline is followed. When guidelines use cardiovascular disease risk factors to dictate therapy, the end benefit is never stated so that the patient can make an appropriate choice of which (if any) guideline to follow. Results: A good example is guidelines published by the American Heart Association for reducing cardiovascular disease. These guidelines are risk factor based and only indicate that cardiovascular disease would be reduced if followed. No specific percentage in the reduction of the incidence of disease is given. In contrast, when elimination of the disease is the stated goal of the guideline, the end result is clear. To date, this goal has been stated by only one organization devoted to eliminating cardiovascular disease. Conclusion: Guidelines need to be written to provide the physician and the patient with a specific end point that is expected when the guideline is followed. Patient acceptance and compliance will be much improved if the patient knows the risk/benefit of following the guideline’s recommendations.
文摘目的:综合评价同期训练对心血管疾病风险因素的干预效果。方法:通过Web of Science、EBSCO、PubMed、Medline、EMBASE、中国知网(CNKI)等数据库检索自建库至2023年6月30日的相关文献,采用Review Manager 5.4软件进行Meta分析,以PEDro量表评价文献质量。共纳入19项研究,涉及921例样本。PEDro量表评分有13篇文献评价为6~8分,6篇文献评价为4~5分,平均值为6分,总体方法学质量较高。结果:同期训练组与对照组相比,对于受试者的收缩压与舒张压的改善虽仅有较小的效应量,但结果仍有显著的改善效果;同期训练能够显著地改善受试者的甘油三酯、总胆固醇,并呈现出小到中等的效应量,但对血糖没有显著影响;同期训练对受试者最大摄氧量有中等程度的改善,且具有非常显著性影响。结论:同期训练能够有效改善受试者的血压(收缩压和舒张压)、最大摄氧量、胆固醇和甘油三酯水平,但对于血糖并未产生积极影响;同期训练对于心血管疾病的预防和改善是一种有效的方法。
