Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine （TCM） researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better ...Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine （TCM） researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory （CHPT）, this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong＇s Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property （qi, flavor and their combinations） and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated： （1） the many-to-one mapping of herbal efficacy to herbal property; （2） the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research.展开更多
该研究通过对外来植物药朝鲜蓟Cynara scolymus的国内外相关文献进行全面查阅,从传统中医药理论角度对朝鲜蓟的中药性能及其功用进行探讨,使朝鲜蓟实现"中药化",为其临床应用与合理配伍提供理论依据。以PubMed、Web of Scienc...该研究通过对外来植物药朝鲜蓟Cynara scolymus的国内外相关文献进行全面查阅,从传统中医药理论角度对朝鲜蓟的中药性能及其功用进行探讨,使朝鲜蓟实现"中药化",为其临床应用与合理配伍提供理论依据。以PubMed、Web of Science、EMbase、Cochrane Library及中国知网(CNKI)、万方、中文科技期刊全文数据库、中国生物医学文献数据库为文献来源,筛选其中与朝鲜蓟相关的可信度较高的文献,将所得文献根据临床应用、化学成分、药理作用、毒副作用等方面进行系统化归类,并结合传统中医理论进行分析,推导得出:朝鲜蓟,味苦,微寒,归脾、胃、肝、胆经。功能消积导滞,理气和胃,清利湿热,化浊降脂。用于消化不良,食少纳呆,呕恶腹胀,胁痛黄疸,高脂血症等。通过对朝鲜蓟的相关文献进行分析研究,使其"中药化",赋予其中药性能与功用,为进一步开展动物实验及临床研究提供理论基础。外来植物药"中药化"的研究模式,可为世界各地植物药的引进及研究提供借鉴,可在极大程度上丰富我国中药资源,并对促进中医药的可持续发展具有重要意义。展开更多
It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia...It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance(NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.展开更多
文摘Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine （TCM） researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory （CHPT）, this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong＇s Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property （qi, flavor and their combinations） and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated： （1） the many-to-one mapping of herbal efficacy to herbal property; （2） the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research.
文摘该研究通过对外来植物药朝鲜蓟Cynara scolymus的国内外相关文献进行全面查阅,从传统中医药理论角度对朝鲜蓟的中药性能及其功用进行探讨,使朝鲜蓟实现"中药化",为其临床应用与合理配伍提供理论依据。以PubMed、Web of Science、EMbase、Cochrane Library及中国知网(CNKI)、万方、中文科技期刊全文数据库、中国生物医学文献数据库为文献来源,筛选其中与朝鲜蓟相关的可信度较高的文献,将所得文献根据临床应用、化学成分、药理作用、毒副作用等方面进行系统化归类,并结合传统中医理论进行分析,推导得出:朝鲜蓟,味苦,微寒,归脾、胃、肝、胆经。功能消积导滞,理气和胃,清利湿热,化浊降脂。用于消化不良,食少纳呆,呕恶腹胀,胁痛黄疸,高脂血症等。通过对朝鲜蓟的相关文献进行分析研究,使其"中药化",赋予其中药性能与功用,为进一步开展动物实验及临床研究提供理论基础。外来植物药"中药化"的研究模式,可为世界各地植物药的引进及研究提供借鉴,可在极大程度上丰富我国中药资源,并对促进中医药的可持续发展具有重要意义。
基金supported by the Science and Technology Innovation Team of Shanxi Province(No.2013131015)Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi(OIT)
文摘It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance(NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.
