We have synthesized a series of compounds based on a piperidyl benzimidazole carboxamide structure,and tested their PARP-1 inhibitory activity,as well as cellular inhibitory activity.Some of them show great potency as...We have synthesized a series of compounds based on a piperidyl benzimidazole carboxamide structure,and tested their PARP-1 inhibitory activity,as well as cellular inhibitory activity.Some of them show great potency as PARP-1 inhibitors and antitumor activity,which are valuable for further research.In addition,the predicted ADME properties and proposed binding mode with PARP-1 of the compounds were obtained via computational simulation.展开更多
Heterogeneous Cu-Mn mixed oxides can mediate TEMPO-catalyzed selective oxidation of benzyl alcohol by molecular oxygen under neutral condition, and is recyclable. In the case of the molar ratio of Cu and Mn over 1, th...Heterogeneous Cu-Mn mixed oxides can mediate TEMPO-catalyzed selective oxidation of benzyl alcohol by molecular oxygen under neutral condition, and is recyclable. In the case of the molar ratio of Cu and Mn over 1, the highly-dispersed CuO inside the Cu-Mn mixed oxides is responsible for the good performances in catalytic oxidation.展开更多
基金Shenzhen Sci.& Tech.Bureau (Nos.JCYJ20170816170342439 and JCYJ20170413113448742) for the financial supports
文摘We have synthesized a series of compounds based on a piperidyl benzimidazole carboxamide structure,and tested their PARP-1 inhibitory activity,as well as cellular inhibitory activity.Some of them show great potency as PARP-1 inhibitors and antitumor activity,which are valuable for further research.In addition,the predicted ADME properties and proposed binding mode with PARP-1 of the compounds were obtained via computational simulation.
基金the National Natural Science Foundation of China (No.20572102)
文摘Heterogeneous Cu-Mn mixed oxides can mediate TEMPO-catalyzed selective oxidation of benzyl alcohol by molecular oxygen under neutral condition, and is recyclable. In the case of the molar ratio of Cu and Mn over 1, the highly-dispersed CuO inside the Cu-Mn mixed oxides is responsible for the good performances in catalytic oxidation.
