Spinal cord injury（SCI）is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the United States.The majority of these cases are young people that will live to almost a full...Spinal cord injury（SCI）is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the United States.The majority of these cases are young people that will live to almost a full life expectancy,however,their quality of life is significantly reduced.After SCI there is loss of both sensory and motor function below the level of injury.展开更多
Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma v...Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact tissue.We explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent manner.Recombinant LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,respectively.While products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major products.Site-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide formation.The high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples.While LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue.展开更多
Various lines of evidence have been used to infer the origin of human bipedalism,but the paucity of hominoid postcranial fossils and the diversity of inferred locomotor modes have tended to confound the reconstruction...Various lines of evidence have been used to infer the origin of human bipedalism,but the paucity of hominoid postcranial fossils and the diversity of inferred locomotor modes have tended to confound the reconstruction of ancestral morphotypes.Examination of the bony labyrinth morphology of the inner ear of extinct and living hominoids provides independent evidence for inferring the evolution of hominoid locomotor patterns.New computed tomography data and morphometric analyses of the Late Miocene ape Lufengpithecus indicate that it and other stem great apes possess labyrinths similar to one another and show that hominoids initially evolved from a positional repertoire that included orthogrady,below-branch forelimb suspension and progression,above-branch bipedalism,climbing,clambering,and leaping(hylobatid-like)to one that comprised above-branch quadrupedalism,below-branch forelimb suspension,vertical climbing,limited leaping,terrestrial quadrupedal running and walking,possibly with knuckle walking,and short bouts of bipedalism(chimpanzee-like).The bony labyrinth morphology of Lufengpithecus indicates that it probably conforms more closely to the last common ancestors of crown hominoids and hominids in its locomotor behavior than do other Miocene hominoids.Human bipedalism evolved from this common archetypal Lufengpithecus-like locomotor repertoire.The low evolutionary rate of semicircular canal morphology suggests that Lufengpithecus experienced a relative stasis in locomotor behavior,probably due to the uplift of the Tibetan Plateau,which created a stable environment in the Miocene of southwestern China.展开更多
The typical average adult head weighs approximately 10-12 pounds.But did you know that bending it forward at a 45-degree angle to look at a cellphone or tablet can dramatically increase your chances[of having]tech nec...The typical average adult head weighs approximately 10-12 pounds.But did you know that bending it forward at a 45-degree angle to look at a cellphone or tablet can dramatically increase your chances[of having]tech neck?"That's like having an 8-pound bowling ball as your head.Then you have 72 pounds at your elbow and 96 pounds on your shoulder,"says Brian Langenhorst,industrial and ergonomics specialist at Mayo Clinic Health System in La Crosse,[Wisconsin]."I probably see tech neck on a weekly basis at businesses,schools and industry."展开更多
Amid Hostile Fan Backlash,Olympic TableTennis Champ Triumphs Netizen Comments:·“Chen Meng probably neverexpected that her Olympicvictory would trigger cyber violence targeting her and the national team coaches.T...Amid Hostile Fan Backlash,Olympic TableTennis Champ Triumphs Netizen Comments:·“Chen Meng probably neverexpected that her Olympicvictory would trigger cyber violence targeting her and the national team coaches.This toxic fan culture is trrible.It also embarrasses Sun Yingsha,who needs to continue working with her teammates and coaches.”展开更多
When you think of the deserts(沙漠),you probably think of cactuses,their strange shapes and sharp spines(尖刺).But why do they look like this?Also,how do they manage to survive(生存)in a hot,dry desert?Their sharp spi...When you think of the deserts(沙漠),you probably think of cactuses,their strange shapes and sharp spines(尖刺).But why do they look like this?Also,how do they manage to survive(生存)in a hot,dry desert?Their sharp spines are part of the secret to their success.Let's find out why!展开更多
Ⅰ.阅读理解.Meredith J.Eberhart completed the 2,190-plus miles,Appalachian Trail on Sunday,becoming the oldest person to hold the honor.Eberhart has probably hiked over 50,000 miles in his life,though he doesn't k...Ⅰ.阅读理解.Meredith J.Eberhart completed the 2,190-plus miles,Appalachian Trail on Sunday,becoming the oldest person to hold the honor.Eberhart has probably hiked over 50,000 miles in his life,though he doesn't keep track of the length.The 83-year-old man started walking when he retired more than 25 years ago,and never stopped.展开更多
主题语境:中国春节篇幅:298词建议用时:6分钟1 Its funny-as a writer,its easy to share your knowledge or your personal stories with an unknown listener of many.You think your friends and family may not...主题语境:中国春节篇幅:298词建议用时:6分钟1 Its funny-as a writer,its easy to share your knowledge or your personal stories with an unknown listener of many.You think your friends and family may not read your articles.You also think your friends show no interest in your food or your culture.However,thats probably not the fact.展开更多
Fleshy fruit shape is an important external quality trait influencing the usage of fruits and consumer preference.Thus,modification of fruit shape has become one of the major objectives for crop improvement.However,th...Fleshy fruit shape is an important external quality trait influencing the usage of fruits and consumer preference.Thus,modification of fruit shape has become one of the major objectives for crop improvement.However,the underlying mechanisms of fruit shape regulation are poorly understood.In this review we summarize recent progress in the genetic basis of fleshy fruit shape regulation using tomato,cucumber,and peach as examples.Comparative analyses suggest that the OFP-TRM(OVATE Family Protein-TONNEAU1 Recruiting Motif)and IQD(IQ67 domain)pathways are probably conserved in regulating fruit shape by primarily modulating cell division patterns across fleshy fruit species.Interestingly,cucumber homologs of FRUITFULL(FUL1),CRABS CLAW(CRC)and 1-aminocyclopropane-1-carboxylate synthase 2(ACS2)were found to regulate fruit elongation.We also outline the recent progress in fruit shape regulation mediated by OFP-TRM and IQD pathways in Arabidopsis and rice,and propose that the OFP-TRM pathway and IQD pathway coordinate regulate fruit shape through integration of phytohormones,including brassinosteroids,gibberellic acids,and auxin,and microtubule organization.In addition,functional redundancy and divergence of the members of each of the OFP,TRM,and IQD families are also shown.This review provides a general overview of current knowledge in fruit shape regulation and discusses the possible mechanisms that need to be addressed in future studies.展开更多
71 cases of Hashimoto’s thyroiditis were treated by moxibustion and their immune functionand thyroid function were observed.It was found that moxibustion was able to reduce thethyroid amibodies in the peripheral bloo...71 cases of Hashimoto’s thyroiditis were treated by moxibustion and their immune functionand thyroid function were observed.It was found that moxibustion was able to reduce thethyroid amibodies in the peripheral blood of the patients with hypothyroidism and to recovertheir thyroid function.It was also found that moxibustion could lower the thyroid antibodysecretory levels and ADCC(antibody-dependent cell mediated cytotoxicity)activities ofthe lymphocytes,in addition,the action of moxibustion in reducing the secretion of thyroidantibodies was related to its action of regulating the proportions of T lymphocyte subsets.The results indicate that the treatment of Hashimoto’s thyroiditis by moxihustion is probably accomplished through its effect in regulating the relationship among the T lymphocytesubsets.展开更多
This book is a volume of translation and commentary of the Epic of Gilgamesh(the Standard Babylonian version consisting of twelve clay tablets),probably composed by a Babylonian scribe named Sin-leqi-unninni in the la...This book is a volume of translation and commentary of the Epic of Gilgamesh(the Standard Babylonian version consisting of twelve clay tablets),probably composed by a Babylonian scribe named Sin-leqi-unninni in the late 2nd millennium BC(A.R.George,The Babylonian Gilgamesh Epic,Introduction,Critical Edition and Cuneiform Texts,Oxford:Oxford University Press,2003,p.30)and mainly excavated from the Ashurbanipal Library of Nineveh.展开更多
To study the synthesis of 3,4-dihydro-2H-3-phenyl-1,3-benzoxazine（benzoxazine）,the reaction paths of phenol,aniline and formaldehyde were investigated by analyzing the synthesis crude products.With the aid of high-p...To study the synthesis of 3,4-dihydro-2H-3-phenyl-1,3-benzoxazine（benzoxazine）,the reaction paths of phenol,aniline and formaldehyde were investigated by analyzing the synthesis crude products.With the aid of high-performance liquid chromatography（HPLC）,chromatographic column and preparative HPLC,seven compounds originated from the crude products were obtained and their chemical structures were elucidated.Possible reaction paths are proposed based on these compounds.Results show that Nhydroxymethyl aniline（HMA） derived from the reaction of formaldehyde and aniline is probably the key intermediate during the reaction.HMA can react with itself or other reactants to form other intermediates,such as 1,3,5-triphenyl-1,3,5-triazinane and 2-（（phenylamino）methyl）phenol,and further form benzoxazine and byproducts.展开更多
THE 19th National Congress of the Communist Party of China（CPC）attracted global attention with1,818 journalists from abroad to cover the event in Beijing on October 18-24,more coverage than for the18th CPC National ...THE 19th National Congress of the Communist Party of China（CPC）attracted global attention with1,818 journalists from abroad to cover the event in Beijing on October 18-24,more coverage than for the18th CPC National Congress.Most of them have been based in China or visited China on several occasions.They have witnessed the changes of Chinese people＇s life in the past five years.展开更多
I have read with interest the comment on our manuscript[1]on different outcomes following cava reconstruction in liver transplantation using either cava replacement or piggy-back technique.Since its initial publicatio...I have read with interest the comment on our manuscript[1]on different outcomes following cava reconstruction in liver transplantation using either cava replacement or piggy-back technique.Since its initial publication by Tsakis in 1989,2]the piggy-back technique has been variously modified.The展开更多
()1.How will Sally probably go to the party?A.By bike.B.On foot.C.By bus.()2.What will the girl wear at the party?A.Her red dress.B.Her new shirt.C.Her nice hat.()3.Where is the man going if it doesn’t rain tomorrow?...()1.How will Sally probably go to the party?A.By bike.B.On foot.C.By bus.()2.What will the girl wear at the party?A.Her red dress.B.Her new shirt.C.Her nice hat.()3.Where is the man going if it doesn’t rain tomorrow?A.The Great Wall.B.The Summer Palace.C.The Palace Museum.()4.What will Lily probably bring to the party?展开更多
Covering nearly all the major concerns of the two sides,the cordial meeting between the presidents of China and the United States prior to the G20 Bali summit sent an uplifting signal to the world that the tension bet...Covering nearly all the major concerns of the two sides,the cordial meeting between the presidents of China and the United States prior to the G20 Bali summit sent an uplifting signal to the world that the tension between the two major countries will probably start to lessen.展开更多
基金the Bryon Riesch Paralysis Foundation for their generous financial support of this study (#133-PRJ57YV)
文摘Spinal cord injury（SCI）is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the United States.The majority of these cases are young people that will live to almost a full life expectancy,however,their quality of life is significantly reduced.After SCI there is loss of both sensory and motor function below the level of injury.
基金This research was financially supported by the Deutsche Forschungsgemeinschaft in frame of the project numbers AOBJ 575560 and AOBJ 575561.
文摘Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact tissue.We explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent manner.Recombinant LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,respectively.While products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major products.Site-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide formation.The high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples.While LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue.
基金The research is supported by the National Natural Science Foundation of China(41888101,41988101,and 41625005)the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK705)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB26030300,XDA20070203,and XDA19050100)。
文摘Various lines of evidence have been used to infer the origin of human bipedalism,but the paucity of hominoid postcranial fossils and the diversity of inferred locomotor modes have tended to confound the reconstruction of ancestral morphotypes.Examination of the bony labyrinth morphology of the inner ear of extinct and living hominoids provides independent evidence for inferring the evolution of hominoid locomotor patterns.New computed tomography data and morphometric analyses of the Late Miocene ape Lufengpithecus indicate that it and other stem great apes possess labyrinths similar to one another and show that hominoids initially evolved from a positional repertoire that included orthogrady,below-branch forelimb suspension and progression,above-branch bipedalism,climbing,clambering,and leaping(hylobatid-like)to one that comprised above-branch quadrupedalism,below-branch forelimb suspension,vertical climbing,limited leaping,terrestrial quadrupedal running and walking,possibly with knuckle walking,and short bouts of bipedalism(chimpanzee-like).The bony labyrinth morphology of Lufengpithecus indicates that it probably conforms more closely to the last common ancestors of crown hominoids and hominids in its locomotor behavior than do other Miocene hominoids.Human bipedalism evolved from this common archetypal Lufengpithecus-like locomotor repertoire.The low evolutionary rate of semicircular canal morphology suggests that Lufengpithecus experienced a relative stasis in locomotor behavior,probably due to the uplift of the Tibetan Plateau,which created a stable environment in the Miocene of southwestern China.
文摘The typical average adult head weighs approximately 10-12 pounds.But did you know that bending it forward at a 45-degree angle to look at a cellphone or tablet can dramatically increase your chances[of having]tech neck?"That's like having an 8-pound bowling ball as your head.Then you have 72 pounds at your elbow and 96 pounds on your shoulder,"says Brian Langenhorst,industrial and ergonomics specialist at Mayo Clinic Health System in La Crosse,[Wisconsin]."I probably see tech neck on a weekly basis at businesses,schools and industry."
文摘Amid Hostile Fan Backlash,Olympic TableTennis Champ Triumphs Netizen Comments:·“Chen Meng probably neverexpected that her Olympicvictory would trigger cyber violence targeting her and the national team coaches.This toxic fan culture is trrible.It also embarrasses Sun Yingsha,who needs to continue working with her teammates and coaches.”
文摘When you think of the deserts(沙漠),you probably think of cactuses,their strange shapes and sharp spines(尖刺).But why do they look like this?Also,how do they manage to survive(生存)in a hot,dry desert?Their sharp spines are part of the secret to their success.Let's find out why!
文摘Ⅰ.阅读理解.Meredith J.Eberhart completed the 2,190-plus miles,Appalachian Trail on Sunday,becoming the oldest person to hold the honor.Eberhart has probably hiked over 50,000 miles in his life,though he doesn't keep track of the length.The 83-year-old man started walking when he retired more than 25 years ago,and never stopped.
文摘主题语境:中国春节篇幅:298词建议用时:6分钟1 Its funny-as a writer,its easy to share your knowledge or your personal stories with an unknown listener of many.You think your friends and family may not read your articles.You also think your friends show no interest in your food or your culture.However,thats probably not the fact.
基金This work was supported by the Natural Science Foundation of Hebei Province(C2021204015)the 2021 Project for the Introduction of Oversea Students in Hebei Province(C20210510)+4 种基金science and technology research projects of colleges and universities in Hebei Province(ZD2022111)the Introduction of Talents Start-up fund of the State Key Laboratory of North China Crop Improvement and Regulation(NCCIR2020RC-13)the Introduction of Talents Start-up fund of Hebei Agricultural University(YJ2020067)the Hebei Fruit Vegetables Seed Industry Science and Technology Innovation Team Project(21326309D)the Vegetable Innovation Team Project of Hebei Modern Agricultural Industrial Technology System(HBCT2018030203).
文摘Fleshy fruit shape is an important external quality trait influencing the usage of fruits and consumer preference.Thus,modification of fruit shape has become one of the major objectives for crop improvement.However,the underlying mechanisms of fruit shape regulation are poorly understood.In this review we summarize recent progress in the genetic basis of fleshy fruit shape regulation using tomato,cucumber,and peach as examples.Comparative analyses suggest that the OFP-TRM(OVATE Family Protein-TONNEAU1 Recruiting Motif)and IQD(IQ67 domain)pathways are probably conserved in regulating fruit shape by primarily modulating cell division patterns across fleshy fruit species.Interestingly,cucumber homologs of FRUITFULL(FUL1),CRABS CLAW(CRC)and 1-aminocyclopropane-1-carboxylate synthase 2(ACS2)were found to regulate fruit elongation.We also outline the recent progress in fruit shape regulation mediated by OFP-TRM and IQD pathways in Arabidopsis and rice,and propose that the OFP-TRM pathway and IQD pathway coordinate regulate fruit shape through integration of phytohormones,including brassinosteroids,gibberellic acids,and auxin,and microtubule organization.In addition,functional redundancy and divergence of the members of each of the OFP,TRM,and IQD families are also shown.This review provides a general overview of current knowledge in fruit shape regulation and discusses the possible mechanisms that need to be addressed in future studies.
文摘71 cases of Hashimoto’s thyroiditis were treated by moxibustion and their immune functionand thyroid function were observed.It was found that moxibustion was able to reduce thethyroid amibodies in the peripheral blood of the patients with hypothyroidism and to recovertheir thyroid function.It was also found that moxibustion could lower the thyroid antibodysecretory levels and ADCC(antibody-dependent cell mediated cytotoxicity)activities ofthe lymphocytes,in addition,the action of moxibustion in reducing the secretion of thyroidantibodies was related to its action of regulating the proportions of T lymphocyte subsets.The results indicate that the treatment of Hashimoto’s thyroiditis by moxihustion is probably accomplished through its effect in regulating the relationship among the T lymphocytesubsets.
文摘This book is a volume of translation and commentary of the Epic of Gilgamesh(the Standard Babylonian version consisting of twelve clay tablets),probably composed by a Babylonian scribe named Sin-leqi-unninni in the late 2nd millennium BC(A.R.George,The Babylonian Gilgamesh Epic,Introduction,Critical Edition and Cuneiform Texts,Oxford:Oxford University Press,2003,p.30)and mainly excavated from the Ashurbanipal Library of Nineveh.
基金supported by the National Natural Science Foundation of China (No.21174093)
文摘To study the synthesis of 3,4-dihydro-2H-3-phenyl-1,3-benzoxazine（benzoxazine）,the reaction paths of phenol,aniline and formaldehyde were investigated by analyzing the synthesis crude products.With the aid of high-performance liquid chromatography（HPLC）,chromatographic column and preparative HPLC,seven compounds originated from the crude products were obtained and their chemical structures were elucidated.Possible reaction paths are proposed based on these compounds.Results show that Nhydroxymethyl aniline（HMA） derived from the reaction of formaldehyde and aniline is probably the key intermediate during the reaction.HMA can react with itself or other reactants to form other intermediates,such as 1,3,5-triphenyl-1,3,5-triazinane and 2-（（phenylamino）methyl）phenol,and further form benzoxazine and byproducts.
文摘THE 19th National Congress of the Communist Party of China（CPC）attracted global attention with1,818 journalists from abroad to cover the event in Beijing on October 18-24,more coverage than for the18th CPC National Congress.Most of them have been based in China or visited China on several occasions.They have witnessed the changes of Chinese people＇s life in the past five years.
文摘I have read with interest the comment on our manuscript[1]on different outcomes following cava reconstruction in liver transplantation using either cava replacement or piggy-back technique.Since its initial publication by Tsakis in 1989,2]the piggy-back technique has been variously modified.The
文摘()1.How will Sally probably go to the party?A.By bike.B.On foot.C.By bus.()2.What will the girl wear at the party?A.Her red dress.B.Her new shirt.C.Her nice hat.()3.Where is the man going if it doesn’t rain tomorrow?A.The Great Wall.B.The Summer Palace.C.The Palace Museum.()4.What will Lily probably bring to the party?
文摘Covering nearly all the major concerns of the two sides,the cordial meeting between the presidents of China and the United States prior to the G20 Bali summit sent an uplifting signal to the world that the tension between the two major countries will probably start to lessen.
