Objective Obstructive sleep apnea (OSA) is closely related to obesity, insulin resistance and inflammation. Secreted frizzled-related protein 5 (SFRP5) is a recently discovered adipokine. It is involved in insulin res...Objective Obstructive sleep apnea (OSA) is closely related to obesity, insulin resistance and inflammation. Secreted frizzled-related protein 5 (SFRP5) is a recently discovered adipokine. It is involved in insulin resistance and inflammation in obesity. This study aimed at evaluating the association between SFRP5and sleeping characteristics as well as biochemical parameters of OSA patients.Methods This was a prospective case control study. Nondiabetic OSA patients and controls were consecutively recruited and divided into three groups: OSA group, apnea–hypopnea Index (AHI)≥5/h; healthy controls with normal body mass index (BMI); obese controls without OSA, and BMI > 24.0 kg/m2. All participants underwent polysomnography (PSG). Plasma SFRP5 was examined using enzyme-linked immunosorbent assay (ELISA). Blood biochemical examinations, including fasting blood glucose (FBG), lipid profile, hypersensitive Creactive protein (hsCRP), were performed early in the morning after PSG. Patients with severe OSA were treated with nasal continuous positive airway pressure (nCPAP), and plasma SFRP5 was repeatedly measured for comparison.Results Sixty-eight subjects were enrolled in the study, including 38 patients of OSA, whose medium AHI was 58.70 /h (36.63, 71.15), 20 obese controls, and 10 healthy controls. The plasma SFRP5 level of OSA patients was not significantly different from that of healthy controls or obese controls. In OSA patients, SFRP5 level correlated positively with triglyceride level (r=0.447, P=0.005) and negatively with LDL-cholesterol level and HDLcholesterol level (r=?0.472 and P=0.003; r=?0.478 and P=0.002; respectively). SFRP5 level was not found correlating with FBG, AHI, or any of nocturnal hypoxia parameters. After overnight nCPAP treatment, plasma SFRP5 levels of OSA patients did not change significantly (t=1.557, P = 0.148) compared to that of pretreatment.Conclusions In nondiabetic OSA patients, plasma SFRP5 is associated with the lipid profile. However,no correlation was observed between SFRP5 an展开更多
目的·对全球范围内已发表的阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)临床实践指南进行质量评价。方法·检索PubMed、Embase、中国知网、万方数据知识服务平台、中国生物医学文献数据库、梅斯医学、The Cochrane Libr...目的·对全球范围内已发表的阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)临床实践指南进行质量评价。方法·检索PubMed、Embase、中国知网、万方数据知识服务平台、中国生物医学文献数据库、梅斯医学、The Cochrane Library、医脉通、美国预防服务工作组网站、英国国家卫生与临床优化研究所网站、新西兰指南工作组网站、苏格兰校际指南网络、国际指南协作网等中的OSA相关指南,检索时间限定为建库至2022年12月。由2名研究人员独立筛选文献和提取信息,采用指南研究和评估工具Ⅱ(Appraisal of Guidelines for Research and EvaluationⅡ,AGREEⅡ)和国际实践指南报告标准(Reporting Items for Practice Guidelines in Healthcare,RIGHT)对纳入的指南进行质量评价,并按不同指南发布地区进行亚组分析;评价者间一致性采用组内相关系数(intra-class correlation coefficient,ICC)进行检验。对所有纳入指南进行全文阅读,汇总其提出的临床问题。结果·共纳入35篇OSA相关指南。评价者ICC为0.975,显示评价者间一致性较好。AGREEⅡ的评价结果显示:纳入指南的平均整体质量分值为(63.60±16.45)%,最低为23.40%,最高为91.67%;6个领域中严谨性[(56.07±25.89)%]和应用性[(53.57±15.52)%]得分较低。RIGHT的评价结果显示,纳入指南的平均总报告率为(67.84±20.03)%,最低为14.29%,最高为94.29%,其中平均报告率较低的领域为评审和质量保证[(31.40±45.51)%]、资金资助和利益冲突声明与管理[(56.43±33.95)%]和其他方面[(56.19±36.85)%]。亚组分析表明,亚洲地区的指南在AGREEⅡ的严谨性及整体的质量得分显著低于美洲和欧洲地区的指南(均P<0.05),在RIGHT的证据和其他方面2个领域的报告率也均显著低于美洲和欧洲地区的指南(P<0.05)。纳入的35部指南主要关注了OSA的筛查诊断、治疗及疾病管理3个方面42个临床问题。结论·目前全球OSA指南质量差异较大,各个展开更多
阻塞性呼吸睡眠障碍(OSA)的监护及诊断因过于复杂而主要限于在医院进行,大量就医已造成医疗机构压力增大。为简化操作、实现对OSA患者的日常监护和初步诊断,本文阐述了一种基于手机的睡眠监测和评估方法。通过Visual Studio 2008下的程...阻塞性呼吸睡眠障碍(OSA)的监护及诊断因过于复杂而主要限于在医院进行,大量就医已造成医疗机构压力增大。为简化操作、实现对OSA患者的日常监护和初步诊断,本文阐述了一种基于手机的睡眠监测和评估方法。通过Visual Studio 2008下的程序开发,实现了手机采集鼾声信号的功能,并在MatLab环境下,对音频信号进行初步处理,定位鼾声信号以及分析患者健康状况。通过计算机模拟鼾声信号的实验表明,该方法较好地实现了上述功能,对异常鼾声信号的诊断结果较为准确。本文为家庭化低成本呼吸睡眠障碍监测提供了重要且现实的技术途径。展开更多
阻塞性睡眠呼吸暂停综合征（Obstructive Sleep Apnea ，OSA ）是以睡眠时反复的气道阻塞为特点，通常伴有其他内科疾病。住院和社区的 OSA 患者都有很高的患抑郁症的风险。抑郁症和 OSA 有很多相同或相似的临床表现，这导致抑郁患者的...阻塞性睡眠呼吸暂停综合征（Obstructive Sleep Apnea ，OSA ）是以睡眠时反复的气道阻塞为特点，通常伴有其他内科疾病。住院和社区的 OSA 患者都有很高的患抑郁症的风险。抑郁症和 OSA 有很多相同或相似的临床表现，这导致抑郁患者的OSA常被漏诊。抑郁症患者的睡眠问题（包括OSA ）很少被规范化评估，这可能是抗抑郁治疗失败的一个重要原因。抑郁症虽然有很多病理生理学机制也能够解释OSA如何引起和加重抑郁，但两者的关系仍不明确。展开更多
文摘Objective Obstructive sleep apnea (OSA) is closely related to obesity, insulin resistance and inflammation. Secreted frizzled-related protein 5 (SFRP5) is a recently discovered adipokine. It is involved in insulin resistance and inflammation in obesity. This study aimed at evaluating the association between SFRP5and sleeping characteristics as well as biochemical parameters of OSA patients.Methods This was a prospective case control study. Nondiabetic OSA patients and controls were consecutively recruited and divided into three groups: OSA group, apnea–hypopnea Index (AHI)≥5/h; healthy controls with normal body mass index (BMI); obese controls without OSA, and BMI > 24.0 kg/m2. All participants underwent polysomnography (PSG). Plasma SFRP5 was examined using enzyme-linked immunosorbent assay (ELISA). Blood biochemical examinations, including fasting blood glucose (FBG), lipid profile, hypersensitive Creactive protein (hsCRP), were performed early in the morning after PSG. Patients with severe OSA were treated with nasal continuous positive airway pressure (nCPAP), and plasma SFRP5 was repeatedly measured for comparison.Results Sixty-eight subjects were enrolled in the study, including 38 patients of OSA, whose medium AHI was 58.70 /h (36.63, 71.15), 20 obese controls, and 10 healthy controls. The plasma SFRP5 level of OSA patients was not significantly different from that of healthy controls or obese controls. In OSA patients, SFRP5 level correlated positively with triglyceride level (r=0.447, P=0.005) and negatively with LDL-cholesterol level and HDLcholesterol level (r=?0.472 and P=0.003; r=?0.478 and P=0.002; respectively). SFRP5 level was not found correlating with FBG, AHI, or any of nocturnal hypoxia parameters. After overnight nCPAP treatment, plasma SFRP5 levels of OSA patients did not change significantly (t=1.557, P = 0.148) compared to that of pretreatment.Conclusions In nondiabetic OSA patients, plasma SFRP5 is associated with the lipid profile. However,no correlation was observed between SFRP5 an
文摘目的·对全球范围内已发表的阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)临床实践指南进行质量评价。方法·检索PubMed、Embase、中国知网、万方数据知识服务平台、中国生物医学文献数据库、梅斯医学、The Cochrane Library、医脉通、美国预防服务工作组网站、英国国家卫生与临床优化研究所网站、新西兰指南工作组网站、苏格兰校际指南网络、国际指南协作网等中的OSA相关指南,检索时间限定为建库至2022年12月。由2名研究人员独立筛选文献和提取信息,采用指南研究和评估工具Ⅱ(Appraisal of Guidelines for Research and EvaluationⅡ,AGREEⅡ)和国际实践指南报告标准(Reporting Items for Practice Guidelines in Healthcare,RIGHT)对纳入的指南进行质量评价,并按不同指南发布地区进行亚组分析;评价者间一致性采用组内相关系数(intra-class correlation coefficient,ICC)进行检验。对所有纳入指南进行全文阅读,汇总其提出的临床问题。结果·共纳入35篇OSA相关指南。评价者ICC为0.975,显示评价者间一致性较好。AGREEⅡ的评价结果显示:纳入指南的平均整体质量分值为(63.60±16.45)%,最低为23.40%,最高为91.67%;6个领域中严谨性[(56.07±25.89)%]和应用性[(53.57±15.52)%]得分较低。RIGHT的评价结果显示,纳入指南的平均总报告率为(67.84±20.03)%,最低为14.29%,最高为94.29%,其中平均报告率较低的领域为评审和质量保证[(31.40±45.51)%]、资金资助和利益冲突声明与管理[(56.43±33.95)%]和其他方面[(56.19±36.85)%]。亚组分析表明,亚洲地区的指南在AGREEⅡ的严谨性及整体的质量得分显著低于美洲和欧洲地区的指南(均P<0.05),在RIGHT的证据和其他方面2个领域的报告率也均显著低于美洲和欧洲地区的指南(P<0.05)。纳入的35部指南主要关注了OSA的筛查诊断、治疗及疾病管理3个方面42个临床问题。结论·目前全球OSA指南质量差异较大,各个
文摘阻塞性呼吸睡眠障碍(OSA)的监护及诊断因过于复杂而主要限于在医院进行,大量就医已造成医疗机构压力增大。为简化操作、实现对OSA患者的日常监护和初步诊断,本文阐述了一种基于手机的睡眠监测和评估方法。通过Visual Studio 2008下的程序开发,实现了手机采集鼾声信号的功能,并在MatLab环境下,对音频信号进行初步处理,定位鼾声信号以及分析患者健康状况。通过计算机模拟鼾声信号的实验表明,该方法较好地实现了上述功能,对异常鼾声信号的诊断结果较为准确。本文为家庭化低成本呼吸睡眠障碍监测提供了重要且现实的技术途径。
文摘阻塞性睡眠呼吸暂停综合征（Obstructive Sleep Apnea ，OSA ）是以睡眠时反复的气道阻塞为特点，通常伴有其他内科疾病。住院和社区的 OSA 患者都有很高的患抑郁症的风险。抑郁症和 OSA 有很多相同或相似的临床表现，这导致抑郁患者的OSA常被漏诊。抑郁症患者的睡眠问题（包括OSA ）很少被规范化评估，这可能是抗抑郁治疗失败的一个重要原因。抑郁症虽然有很多病理生理学机制也能够解释OSA如何引起和加重抑郁，但两者的关系仍不明确。
