摘要
目的通过Meta分析探讨阻塞性睡眠呼吸暂停(Obstructive sleep apnea,OSA)与前列腺癌发生风险的关系。方法检索PubMed、EMBase、Web of Science、The Corchrane Library、中国知网(CNKI)、中国生物医学文献(CBM)、万方数据库,收集所有符合纳入标准的中英文文献,再根据已发表文献中的参考文献追溯进行手工检索,检索年限自建库至2023年12月,均由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件进行Meta分析。为了计算患前列腺癌和阻塞性睡眠呼吸暂停的风险比(HR),只纳入了多变量队列研究进行分析。结果该研究包括从2164篇文章中提取的7项队列研究,其结果显示患有睡眠呼吸暂停的男性患前列腺癌的风险明显更高(HR:1.61,95%CI:1.02~2.53,P=0.04)。亚组分析显示:与非老年男性相比,患有OSA的老年男性的前列腺癌风险显著增加(调整HR:2.57,95%CI:2.18~3.03,P<0.01),亚组内无异质性(I^(2)=0,P>0.1),各亚组间的差异有统计学意义(I^(2)=95.9%,P<0.1),其余亚组分析无法区分这种关联的差异。结论OSA患者患前列腺癌的风险显著增加并存在显著的异质性,且这种相关性在老年男性中更为显著。
Objective A meta-analysis was conducted to investigate the relationship between obstructive sleep apnea(OSA)and prostate cancer risk.Methods PubMed,EMBase,Web of Science,The Corchrane Library,China Knowledge Network(CNKI),China Biomedical Literature(CBM),and Wanfang databases were searched to collect all Chinese and English literatures that met the inclusion criteria,and then itmanually searched according to the references retrospectively in published literature.The search was performed manually based on the reference tracing in published literature,and the year of search was from the establishment of the database to December 2023.2 evaluators independently screened the literature,extracted the information,and evaluated the risk of bias of the included studies,and then performed meta-analysis by using RevMan 5.4 software.To calculated Hazard Ratio(HR)for developing prostate cancer and obstructive sleep apnea,only multivariate cohort studies were included for analysis.Results The results of the study,which included 7 cohort studies extracted from 2164 articles,it showed that men with obstructive sleep apnea had a significantly higher risk of developing prostate cancer(HR:1.61,95%CI:1.02~2.53,P=0.04).Subgroup analysis showed that older men with obstructive sleep apnea had a significantly higher risk of prostate cancer and were more likely to develop cancer than non-older men(adjusted HR:2.57,95%CI:2.18~3.03,P<0.01).There was no heterogeneity within subgroups(I^(2)=0,P>0.1),the difference between subgroups was statistically significant(I^(2)=95.9%,P<0.1),and the remaining subgroups analyzed were unable to differentiate between differences in this association.Conclusion The patients with OSA have a significantly increased and heterogeneous risk of prostate cancer,and the association is more pronounced in older men.
作者
张凯歌
卜珂
姚淼
安恒庆
ZHANG Kaige;BU Ke;YAO Miao;AN Hengqing(The First Affiliated Hospital,Urumqi 830054,China;School of Public Health,Xinjiang Medical University,Urumqi 830017,China)
出处
《新疆医科大学学报》
CAS
2024年第4期602-608,共7页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区杰出青年科学基金项目(2023D01E05)
国家自然科学基金地区科学基金项目(82360476)。
