摘要
目的阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是一种在临床有较高病发率的睡眠障碍,其病发机制为上气道在睡眠期间反复阻塞,会引发低氧血症、频繁低通气、睡眠唤醒、呼吸暂停等病理生理改变。多导睡眠监测(polysomography,PSG)是临床上诊断OSA的金标准,可以监测患者睡眠期间的脑电波变化。本文通过分析重度OSA男性患者睡眠规律和脑电(electroencephalogram,EEG)能量密度分布及变化规律,探究重度OSA患者的睡眠脑电变化。方法选取30名男性重度OSA患者和30名男性正常对照组,对60名受试者进行整夜(8 h左右)的多导睡眠监测,对得到的睡眠特征和脑电参数进行整理,提取睡眠与脑电特征。对比睡眠监测得到的睡眠特征和其前额区的脑电能量密度。结果在睡眠特征方面,重度OSA患者睡眠期时间为370.20 min,睡眠效率平均为86.90%,非快速眼动1期平均占比19.90%,非快速眼动2期平均占比42.55%,对比正常人睡眠时间、睡眠效率以及非快速眼动1期、2期占比明显降低。在脑电特征方面,重度OSA患者整夜睡眠θ波的绝对能量密度、总能量密度、相对能量密度delta波、K复合波的相对能量密度高于对照组,β波相对功率低于对照组。OSA患者脑电低频活动增加明显。结论随着OSA患者严重程度的加重,患者的脑电能量与低频活动增加明显,为OSA患者疾病的发展趋势和评估疗效提供了重要的参考依据。
Objective Obstructive sleep apnea(OSA)is a sleep disorder with a high incidence rate in clinical practice.Its pathogenesis is the repeated obstruction of the upper airway during sleep,which can cause pathological and physiological changes such as hypoxemia,frequent hypoventilation,sleep arousal,and respiratory pauses.Polysomnography(PSG)is the gold standard for diagnosing obstructive sleep apnea(OSA)in clinical practice,which can monitor changes in the brain waves of patients during sleep.This article analyzes the sleep patterns and energy density distribution and changes of electroencephalogram(EEG)in male patients with severe OSA,and explores the sleep EEG changes in patients with severe OSA.Methods We selected 30 male patients with severe apnea syndrome and 30 male normal controls,and monitored polysomnography in 60 subjects all night.The obtained sleep characteristics and EEG parameters were sorted and extracted.The sleep characteristics and EEG energy density of prefrontal area were compared.Results In terms of sleep characteristics,the sleep period time of severe OSA patients was 370.20min,the average sleep efficiency was 86.90%,the average proportion of non-rapid eye movement stage 1 was 1990%,and the average proportion of non-rapid eye movement stage 2 was 4255%.Compared with normal people,the sleep time,sleep efficiency and the proportion of non-rapid eye movement stage 1 and stage 2 were significantly reduced.In terms of EEG characteristics,the absolute energy density,total energy density,relative energy density delta wave and K complex wave of sleep in severe OSA patients were higher than those in the control group,and the relative power ofβwave was lower than that in the control group.The low frequency EEG activity was significantly increased in OSA patients.Conclusions With the aggravation of the severity of OSA patients,the EEG energy and low frequency activity of patients increased significantly,which provides an important reference for the development trend of OSA patients and the evaluation of c
作者
常丹丹
蔡晓畅
毕军
赵智玲
张宽
全海英
CHANG Dandan;CAI Xiaochang;BI Jun;ZHAO Zhiling;ZHANG Kuan;QUAN Haiying(School of Biomedical Engineering,Capital Medical University,Beijing 100069;Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application,Beijing 100069;Department of Respiratory and Critical Care Medicine,Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020)
出处
《北京生物医学工程》
2024年第1期58-65,共8页
Beijing Biomedical Engineering
基金
北京市教育委员会科技发展计划一般项目(KM201810025013)资助。
关键词
阻塞性睡眠呼吸暂停
脑电
呼吸暂停低通气指数
脑电能量密度
obstructive sleep apnea(OSA)
electroencephalogram(EEG)
apnea-hypopnea index(AHI)
EEG energy density
