Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability.Recent years have witnessed broad interests and advances on surface functionalization of m...Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability.Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions.Calcium phosphates(CaPs)are the major inorganic component of bone tissues,and thus owning inherent biocompatibility and osseointegration properties.As such,they have been widely used in clinical orthopedics and dentistry.The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs.This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances,and then give insight into the representative biofunctions,i.e.osteointegration,corrosion resistance and biodegradation control,and antibacterial property,provided by CaP coatings for metallic implant materials.展开更多
背景:作为骨科内植物的主要材料,钛及其合金在包括骨科在内的多个医学领域得到广泛的应用,内植物相关性感染也随之增多,采取不同的制备方法将优异且机制清楚的抗菌金属铜加入其中,在不影响生物力学性能的同时可使其具备一定的抗菌能力...背景:作为骨科内植物的主要材料,钛及其合金在包括骨科在内的多个医学领域得到广泛的应用,内植物相关性感染也随之增多,采取不同的制备方法将优异且机制清楚的抗菌金属铜加入其中,在不影响生物力学性能的同时可使其具备一定的抗菌能力。目的:综述医用含铜钛合金的抗菌性能研究进展及发展趋势。方法:应用计算机检索PubMed、Web of Science数据库中2003年1月至2022年3月的相关文献,检索词为“Titanium alloy,Copper,Antibacterial,Surface modification,Coating”,根据纳入排除标准对选定的76篇文献进行分析讨论。结果与结论:①加入铜的钛合金在体内外抗菌实验中均显示出良好的抗菌性能,并随着铜含量的提升其抗菌性能更加明显。②但目前仍存在较多问题有待解决:探索、优化加入铜的含量、方式及采取合适的制备工艺使合金的抗菌性能、生物相容性、机械性能达到平衡需要进一步的实验;表面改性对合金表面的微损伤是否会对合金造成不利影响;铜离子释放速率的控制以及如何避免早期突然大量释放铜离子的“突释现象”。展开更多
In the present work, osteoblast behavior on a hierarchical micro-/nano-structured titanium surface was investigated. A hi- erarchical hybrid micro-/nano-structured titanium surface topography was produced via Electrol...In the present work, osteoblast behavior on a hierarchical micro-/nano-structured titanium surface was investigated. A hi- erarchical hybrid micro-/nano-structured titanium surface topography was produced via Electrolytic Etching （EE）. MG-63 cells were cultured on disks for 2 h to 7 days. The osteoblast response to the hierarchical hybrid micro-/nano-structured titanium surface was evaluated through the osteoblast cell morphology, attachment and proliferation. For comparison, MG-63 cells were also cultured on Sandblasted and Acid-etched （SEA） as well as Machined （M） surfaces respectively. The results show signifi- cant differences in the adhesion rates and proliferation levels of MG-63 cells on EE, SLA, and M surfaces. Both adhesion rate and proliferation level on EE surface are higher than those on SLA and M surfaces. Therefore, we may expect that, comparing with SLA and M surfaces, bone growth on EE surface could be accelerated and bone formation could be promoted at an early stage, which could be applied in the clinical practices for immediate and early-stage loadings.展开更多
背景:近年来,金属有机框架由于其特有性质在生物医学领域应用广泛,可以将金属有机框架应用于种植体表面改性,以改善其生物学性能,提高手术成功率。目的:介绍种植体表面改性领域常用的金属有机框架以及种植体表面金属有机框架改性的制备...背景:近年来,金属有机框架由于其特有性质在生物医学领域应用广泛,可以将金属有机框架应用于种植体表面改性,以改善其生物学性能,提高手术成功率。目的:介绍种植体表面改性领域常用的金属有机框架以及种植体表面金属有机框架改性的制备和作用机制。方法:采用计算机检索中国知网、PubMed和Web of Science数据库中有关金属有机框架应用于种植体表面改性的研究资料,选取发表于2010-2023年的相关文献,最终纳入64篇文献进行综述分析。结果与结论:①金属有机框架具有孔隙率高、比表面积大及空间结构多样等性质,作为一种生物活性材料,金属有机框架在组织工程和再生医学中逐渐引起重视。②种植体改性领域常用的金属有机框架类型主要有3种:类沸石骨架材料最常作为载体应用,负载各种药物和生物分子,MIL系列材料适用于药物载体和纳米酶,Bio-金属有机框架因结构多样而应用广泛,突出特点是优异的生物安全性。③金属有机框架改性的种植体材料制备方法大致分为两类,第一类是将已合成的金属有机框架结合到预处理植入材料上,第二类是在预处理的材料表面原位合成金属有机框架。④种植体表面的金属有机框架通过降解释放自身组分、负载药物、催化活性反应及与其他材料联合等多种机制,赋予种植体抗菌抗炎促进骨整合的特性,但金属有机框架涂层制备方法还需要进一步完善,同时应深入探究材料后续代谢和分布问题,积极推动其在临床上的应用。展开更多
Stable soft tissue integration around the implant abutment attenuates pathogen penetration,protects underlying bone tissue,prevents peri-implantitis and is essential in maintaining long-term implant stability.The desi...Stable soft tissue integration around the implant abutment attenuates pathogen penetration,protects underlying bone tissue,prevents peri-implantitis and is essential in maintaining long-term implant stability.The desire for“metal free”and“aesthetic restoration”has favored zirconia over titanium abutments,especially for implant restorations in the anterior region and for patients with thin gingival biotype.Soft tissue attachment to the zirconia abutment surface remains a challenge.A comprehensive review of advances in zirconia surface treatment(micro-design)and structural design(macro-design)affecting soft tissue attachment is presented and strategies and research directions are discussed.Soft tissue models for abutment research are described.Guidelines for development of zirconia abutment surfaces that promote soft tissue integration and evidence-based references to inform clinical choice of abutment structure and postoperative maintenance are presented.展开更多
Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tis...Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation.However,choosing an appropriate bioactive material that suits to the application and provides the desired mechanical,physical,chemical and biological functionality,as well as understanding the aspects of biological reaction to the biomaterial,in particular immune response,it plays a key role in successful integration of the implant.In this review,we will discuss different bioactive materials including bioactive ceramics,polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent studies.Considering the necessity of regulation of implant fate for higher biocompatibility,the comprehensive overview to the immune response will be reviewed with the focus on representing the cell-biomaterial interactions and more importantly,the inflammatory responses.Ultimately,we will also discuss about different approaches namely as immunomodulation to elicit the desired physiochemical properties and mimicking native cellular response using bioactive compounds,functionalizing the implant surface with active molecules and alteration of the surface morphology.With better understanding of bioactive materials and their interactions with body,more novel biomaterials representing desired properties can be designed.展开更多
Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machi...Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and biodegradability.The primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the implant.Laser surface modification has recently received attention because it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the material.The composition and microstructures including textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques including laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant applications.Additionally,we explore how different laser process parameters affect its composition,microstructure,and surface properties in each laser surface modification technique.展开更多
基金supported by National Institutes of Health[Grant number R01HL140562]。
文摘Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability.Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions.Calcium phosphates(CaPs)are the major inorganic component of bone tissues,and thus owning inherent biocompatibility and osseointegration properties.As such,they have been widely used in clinical orthopedics and dentistry.The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs.This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances,and then give insight into the representative biofunctions,i.e.osteointegration,corrosion resistance and biodegradation control,and antibacterial property,provided by CaP coatings for metallic implant materials.
文摘背景:作为骨科内植物的主要材料,钛及其合金在包括骨科在内的多个医学领域得到广泛的应用,内植物相关性感染也随之增多,采取不同的制备方法将优异且机制清楚的抗菌金属铜加入其中,在不影响生物力学性能的同时可使其具备一定的抗菌能力。目的:综述医用含铜钛合金的抗菌性能研究进展及发展趋势。方法:应用计算机检索PubMed、Web of Science数据库中2003年1月至2022年3月的相关文献,检索词为“Titanium alloy,Copper,Antibacterial,Surface modification,Coating”,根据纳入排除标准对选定的76篇文献进行分析讨论。结果与结论:①加入铜的钛合金在体内外抗菌实验中均显示出良好的抗菌性能,并随着铜含量的提升其抗菌性能更加明显。②但目前仍存在较多问题有待解决:探索、优化加入铜的含量、方式及采取合适的制备工艺使合金的抗菌性能、生物相容性、机械性能达到平衡需要进一步的实验;表面改性对合金表面的微损伤是否会对合金造成不利影响;铜离子释放速率的控制以及如何避免早期突然大量释放铜离子的“突释现象”。
文摘In the present work, osteoblast behavior on a hierarchical micro-/nano-structured titanium surface was investigated. A hi- erarchical hybrid micro-/nano-structured titanium surface topography was produced via Electrolytic Etching （EE）. MG-63 cells were cultured on disks for 2 h to 7 days. The osteoblast response to the hierarchical hybrid micro-/nano-structured titanium surface was evaluated through the osteoblast cell morphology, attachment and proliferation. For comparison, MG-63 cells were also cultured on Sandblasted and Acid-etched （SEA） as well as Machined （M） surfaces respectively. The results show signifi- cant differences in the adhesion rates and proliferation levels of MG-63 cells on EE, SLA, and M surfaces. Both adhesion rate and proliferation level on EE surface are higher than those on SLA and M surfaces. Therefore, we may expect that, comparing with SLA and M surfaces, bone growth on EE surface could be accelerated and bone formation could be promoted at an early stage, which could be applied in the clinical practices for immediate and early-stage loadings.
文摘背景:近年来,金属有机框架由于其特有性质在生物医学领域应用广泛,可以将金属有机框架应用于种植体表面改性,以改善其生物学性能,提高手术成功率。目的:介绍种植体表面改性领域常用的金属有机框架以及种植体表面金属有机框架改性的制备和作用机制。方法:采用计算机检索中国知网、PubMed和Web of Science数据库中有关金属有机框架应用于种植体表面改性的研究资料,选取发表于2010-2023年的相关文献,最终纳入64篇文献进行综述分析。结果与结论:①金属有机框架具有孔隙率高、比表面积大及空间结构多样等性质,作为一种生物活性材料,金属有机框架在组织工程和再生医学中逐渐引起重视。②种植体改性领域常用的金属有机框架类型主要有3种:类沸石骨架材料最常作为载体应用,负载各种药物和生物分子,MIL系列材料适用于药物载体和纳米酶,Bio-金属有机框架因结构多样而应用广泛,突出特点是优异的生物安全性。③金属有机框架改性的种植体材料制备方法大致分为两类,第一类是将已合成的金属有机框架结合到预处理植入材料上,第二类是在预处理的材料表面原位合成金属有机框架。④种植体表面的金属有机框架通过降解释放自身组分、负载药物、催化活性反应及与其他材料联合等多种机制,赋予种植体抗菌抗炎促进骨整合的特性,但金属有机框架涂层制备方法还需要进一步完善,同时应深入探究材料后续代谢和分布问题,积极推动其在临床上的应用。
基金supported by the National Nature Science Foundation of China(grants 81720108011,82071169,82100971).
文摘Stable soft tissue integration around the implant abutment attenuates pathogen penetration,protects underlying bone tissue,prevents peri-implantitis and is essential in maintaining long-term implant stability.The desire for“metal free”and“aesthetic restoration”has favored zirconia over titanium abutments,especially for implant restorations in the anterior region and for patients with thin gingival biotype.Soft tissue attachment to the zirconia abutment surface remains a challenge.A comprehensive review of advances in zirconia surface treatment(micro-design)and structural design(macro-design)affecting soft tissue attachment is presented and strategies and research directions are discussed.Soft tissue models for abutment research are described.Guidelines for development of zirconia abutment surfaces that promote soft tissue integration and evidence-based references to inform clinical choice of abutment structure and postoperative maintenance are presented.
文摘Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation.However,choosing an appropriate bioactive material that suits to the application and provides the desired mechanical,physical,chemical and biological functionality,as well as understanding the aspects of biological reaction to the biomaterial,in particular immune response,it plays a key role in successful integration of the implant.In this review,we will discuss different bioactive materials including bioactive ceramics,polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent studies.Considering the necessity of regulation of implant fate for higher biocompatibility,the comprehensive overview to the immune response will be reviewed with the focus on representing the cell-biomaterial interactions and more importantly,the inflammatory responses.Ultimately,we will also discuss about different approaches namely as immunomodulation to elicit the desired physiochemical properties and mimicking native cellular response using bioactive compounds,functionalizing the implant surface with active molecules and alteration of the surface morphology.With better understanding of bioactive materials and their interactions with body,more novel biomaterials representing desired properties can be designed.
基金the Australian Research Council(ARC)through the discovery grant DP210101862。
文摘Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and biodegradability.The primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the implant.Laser surface modification has recently received attention because it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the material.The composition and microstructures including textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques including laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant applications.Additionally,we explore how different laser process parameters affect its composition,microstructure,and surface properties in each laser surface modification technique.
