摘要
在种植体表面引入微纳分级的多孔粗糙结构,将为种植体的表面带来更大的比表面积,同时增加种植体表面的粗糙层厚度并改善表面润湿性,进而实现稳定、快速的骨整合。为了提高钛合金种植体的生物相容性,提高临床植入手术的成功率,采用合金化的方式制备了4种弹性模量极低的型钛合金,并通过喷丸、双酸酸蚀、碱热处理的复合工艺在钛合金材料表面制备出了超亲水的微纳分级多孔结构,这种结构表现出了超亲水性(接触角<5°)。此外,SLA+AT Ti38Nb和SLA+AT Ti2448样品表面具有最厚的粗糙层(3.30μm),且对羟基磷灰石的沉积能力最强。证实了复合工艺能够在钛合金表面制备出稳定的微纳分级多孔结构,并且证实了这种结构是有益于提升钛合金种植体表面的生物相容性能的。
The introduction of micro/nano hierarchical porous structure will bring greater specific surface area for the implant surface,increase the thickness of the rough layer,improve the surface wettability,and finally achieve stable and rapid osseointegration.In order to improve the biocompatibility of the titanium alloy implant and improve the success rate of the clinical implant surgery,four kinds ofβ-type titanium alloys with very low elastic modulus are prepared by alloying in this paper.Super hydrophilic micro/nano hierarchical porous structure is prepared on the surface of titanium alloy by sand blasting,dual-acid etching,and alkali heat treatment.It is confirmed that this structure is beneficial to the deposition of hydroxyapatite.The surface of titanium alloys shows super hydrophilicity(contact angle<5°).Furthermore,SLA+AT Ti38Nb and SLA+AT Ti2448 samples exhibit the thickest rough layer(3.30μm),and shows the best biocompatibility.In this study,it is confirmed that the composite process can produce a stable micro-nano hierarchical porous structure on the surface of titanium alloy and this structure is beneficial to improve the biocompatibility of the surface of titanium alloy implant.
作者
吴丽煌
金明江
刘剑楠
韩婧
金学军
WU Lihuang;JIN Mingjiang;LIU Jiannan;HAN Jing;JIN Xuejun(School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China;Shanghai Ninth People's Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200011, China)
出处
《功能材料》
CAS
CSCD
北大核心
2021年第7期7024-7031,7051,共9页
Journal of Functional Materials
基金
国家自然基金资助项目(51201100,51821001,8190030324)
学科交叉培养(转化)资助项目(ZH2018QNA04)。
关键词
超亲水
医用植入
表面改性
碱热处理
super hydrophilicity
medical implant
surface modification
alkaline treatment
