Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups...Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups;one group was treated with Zhuangshen Gujing(n=36;treatment group)and the other group was treated with irbesartan(n=36;control group).After 6 months’treatment,urine protein and renal function were evaluated.Results:Proteinuria resolved completely in four patients in the treatment group;complete disease resolution was observed only among three individuals in the control group.Of the 32 cases remaining in the treatment group,15 had substantial responses to Zhuangshen Gujing decoction,9 had partial responses,and 8 had no response to treatment;the overall the response rate was 73.33%.Among the 33 cases remaining in the control group,12 had a substantial response to irbesartan,5 had a partial response,and 16 had no response to treatment;the overall response rate among the controls was 57.67%(P=0.031).We also observed statistically significant differences with respect to quantitative comparisons of urinary protein at 24 days after a single course of treatment(P=0.001).Conclusion:Zhuangshen Gujing decoction is effective in treating chronic nephritis proteinuria.展开更多
文摘Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups;one group was treated with Zhuangshen Gujing(n=36;treatment group)and the other group was treated with irbesartan(n=36;control group).After 6 months’treatment,urine protein and renal function were evaluated.Results:Proteinuria resolved completely in four patients in the treatment group;complete disease resolution was observed only among three individuals in the control group.Of the 32 cases remaining in the treatment group,15 had substantial responses to Zhuangshen Gujing decoction,9 had partial responses,and 8 had no response to treatment;the overall the response rate was 73.33%.Among the 33 cases remaining in the control group,12 had a substantial response to irbesartan,5 had a partial response,and 16 had no response to treatment;the overall response rate among the controls was 57.67%(P=0.031).We also observed statistically significant differences with respect to quantitative comparisons of urinary protein at 24 days after a single course of treatment(P=0.001).Conclusion:Zhuangshen Gujing decoction is effective in treating chronic nephritis proteinuria.
文摘目的探讨益气温阳固精汤对原发性肾病综合征(Primary nephrotic syndrome,PNS)肾素(Renin,REN)、血管紧张素Ⅱ受体(AngiotensinⅡreceptor,AngⅡ)、醛固酮(Aldosterone,ALD)水平及疗效的影响。方法100例PNS患者以随机数字表法分为对照组和研究组;对照组给予西医常规方案治疗,研究组在对照组基础上加用益气温阳固精汤治疗。比较两组的中医症候积分变化、治疗有效率、肾功能相关指标[血肌酐(Serum creatinine,Scr)、尿素氮(Blood urea nitrogen,BUN)、24 h尿蛋白定量(24 h Urinary protein,24 h Upro)]、REN、AngⅡ、ALD及不良反应发生情况。结果治疗后两组中医症候积分均较治疗前下降(P<0.05),且研究组低于对照组(P<0.05)。研究组治疗有效率高于对照组(P<0.05)。治疗后两组的Scr、BUN、24 h Upro、REN、AngⅡ、ALD水平均下降,且研究组均低于对照组(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论在PNS患者的治疗中应用益气温阳固精汤更利于改善症状,提高治疗效果,降低REN、AngⅡ、ALD水平。
