The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylate...The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C(1) and five known C-geranylated flavanones(2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH_2Cl_2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H_2O_2. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone(3) and paucatalinone A(5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H_2O_2 and the C-geranyl substituent may be an important factor because of its lipophilic character.展开更多
Since the late Ming dynasty to 1856 Qing dynasty,"shu shui gong sha"is the authentic theorem of water-control in lower reaches of Huang-he river,but plan was always used period of time which appeared problem...Since the late Ming dynasty to 1856 Qing dynasty,"shu shui gong sha"is the authentic theorem of water-control in lower reaches of Huang-he river,but plan was always used period of time which appeared problem and to be fail.Based History geography’s view,we can see it was resulted in land-increasing and bayou-extending from bedload which be eroded by water.In Ming and Qing dynasty,the coastline varied prodigiouss near the bayou,the bayou reached 90 km eastwardly,which elongated the riverway in lower reaches of Huang-he river in disguised form,caused the gradient minish,the water flowed slowly,the bedload deposited on riverbed,which conduced the bank bursted easily in the flood season,result flood in a high frequency.Finally,the river to be hang river,the bank difficult to be maintained,the Huang-he river be compelled to flow northly to the Bo-hai sea,the "shu shui gong sha" failed.展开更多
基金financially supported by the Natural Science Foundation of Shandong Academy of Medical Sciences(No.2015-08)the Innovation Project of Shandong Academy of Medical Sciences and the Natural Science Open Foundation of State Key Laboratory of Bioactive Substance and Function of Natural Medicines(No.GTZK201503)
文摘The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C(1) and five known C-geranylated flavanones(2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH_2Cl_2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H_2O_2. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone(3) and paucatalinone A(5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H_2O_2 and the C-geranyl substituent may be an important factor because of its lipophilic character.
文摘Since the late Ming dynasty to 1856 Qing dynasty,"shu shui gong sha"is the authentic theorem of water-control in lower reaches of Huang-he river,but plan was always used period of time which appeared problem and to be fail.Based History geography’s view,we can see it was resulted in land-increasing and bayou-extending from bedload which be eroded by water.In Ming and Qing dynasty,the coastline varied prodigiouss near the bayou,the bayou reached 90 km eastwardly,which elongated the riverway in lower reaches of Huang-he river in disguised form,caused the gradient minish,the water flowed slowly,the bedload deposited on riverbed,which conduced the bank bursted easily in the flood season,result flood in a high frequency.Finally,the river to be hang river,the bank difficult to be maintained,the Huang-he river be compelled to flow northly to the Bo-hai sea,the "shu shui gong sha" failed.
