BACKGROUND Neurosurgical treatment of severe bilateral occipital lobe epilepsy usually involves two operations several mos apart.AIM To evaluate surgical resection of bilateral occipital lobe lesions during a single o...BACKGROUND Neurosurgical treatment of severe bilateral occipital lobe epilepsy usually involves two operations several mos apart.AIM To evaluate surgical resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe epilepsy.METHODS This retrospective case series included patients with drug-refractory bilateral occipital lobe epilepsy treated surgically between March 2006 and November 2015.RESULTS Preoperative evaluation included scalp video-electroencephalography(EEG),magnetic resonance imaging,and PET-CT.During surgery(bilateral occipital craniotomy),epileptic foci and important functional areas were identified by EEG(intracranial cortical electrodes)and cortical functional mapping,respectively.Patients were followed up for at least 5 years to evaluate treatment outcome(Engel grade)and visual function.The 20 patients(12 males)were aged 4-30 years(median age,12 years).Time since onset was 3-20 years(median,8 years),and episode frequency was 4-270/mo(median,15/mo).Common manifestations were elementary visual hallucinations(65.0%),flashing lights(30.0%),blurred vision(20.0%)and visual field defects(20.0%).Most patients were free of disabling seizures(Engel grade I)postoperatively(18/20,90.0%)and at 1 year(18/20,90.0%),3 years(17/20,85.0%)and≥5 years(17/20,85.0%).No patients were classified Engel grade IV(no worthwhile improvement).After surgery,there was no change in visual function in 13/20(65.0%),development of a new visual field defect in 3/20(15.0%),and worsening of a preexisting defect in 4/20(20.0%).CONCLUSION Resection of bilateral occipital lobe lesions during a single operation may be applicable in bilateral occipital lobe epilepsy.展开更多
Stereo-electroencephalography （SEEG） is the main investigation method for pre-surgical evaluation of patients suffering from drug-resistant partial epilepsy. SEEG signals reflect two types of paroxysmal activity： i...Stereo-electroencephalography （SEEG） is the main investigation method for pre-surgical evaluation of patients suffering from drug-resistant partial epilepsy. SEEG signals reflect two types of paroxysmal activity： ictal activity and interictal activity or interictal spikes （IS）. The relationship between IS and ictal activity is an essential and recurrent question in epiletology. In this paper, we present a distributed and parallel architecture for space and temporal distribution analysis of IS, based on a distributed and collaborative methodology. The proposed approach exploits the SEEG data using vector analysis of the corresponding signals among multi-agents system. The objective is to present a new method to analyze and classify IS during wakefulness （W）, light sleep （LS） and deep sleep （DS） stages. Temporal and spatial relationships between IS and seizure onset zone are compared during wakefulness, light sleep and deep sleep. Results show that space and temporal distribution for real data are not random but correlated.展开更多
文摘BACKGROUND Neurosurgical treatment of severe bilateral occipital lobe epilepsy usually involves two operations several mos apart.AIM To evaluate surgical resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe epilepsy.METHODS This retrospective case series included patients with drug-refractory bilateral occipital lobe epilepsy treated surgically between March 2006 and November 2015.RESULTS Preoperative evaluation included scalp video-electroencephalography(EEG),magnetic resonance imaging,and PET-CT.During surgery(bilateral occipital craniotomy),epileptic foci and important functional areas were identified by EEG(intracranial cortical electrodes)and cortical functional mapping,respectively.Patients were followed up for at least 5 years to evaluate treatment outcome(Engel grade)and visual function.The 20 patients(12 males)were aged 4-30 years(median age,12 years).Time since onset was 3-20 years(median,8 years),and episode frequency was 4-270/mo(median,15/mo).Common manifestations were elementary visual hallucinations(65.0%),flashing lights(30.0%),blurred vision(20.0%)and visual field defects(20.0%).Most patients were free of disabling seizures(Engel grade I)postoperatively(18/20,90.0%)and at 1 year(18/20,90.0%),3 years(17/20,85.0%)and≥5 years(17/20,85.0%).No patients were classified Engel grade IV(no worthwhile improvement).After surgery,there was no change in visual function in 13/20(65.0%),development of a new visual field defect in 3/20(15.0%),and worsening of a preexisting defect in 4/20(20.0%).CONCLUSION Resection of bilateral occipital lobe lesions during a single operation may be applicable in bilateral occipital lobe epilepsy.
文摘Stereo-electroencephalography （SEEG） is the main investigation method for pre-surgical evaluation of patients suffering from drug-resistant partial epilepsy. SEEG signals reflect two types of paroxysmal activity： ictal activity and interictal activity or interictal spikes （IS）. The relationship between IS and ictal activity is an essential and recurrent question in epiletology. In this paper, we present a distributed and parallel architecture for space and temporal distribution analysis of IS, based on a distributed and collaborative methodology. The proposed approach exploits the SEEG data using vector analysis of the corresponding signals among multi-agents system. The objective is to present a new method to analyze and classify IS during wakefulness （W）, light sleep （LS） and deep sleep （DS） stages. Temporal and spatial relationships between IS and seizure onset zone are compared during wakefulness, light sleep and deep sleep. Results show that space and temporal distribution for real data are not random but correlated.
