1-O-methyl-3,5-2-O-(2,4-dichlorobenzyl)-D-ribofuranose-2-tone was produced by oxidizing 1-O-methyl-3,5-bis-O-(2,4-dichlorobenzyl)-D-ribofuranose,which was synthesized from hydroxyl protection and selectively removing ...1-O-methyl-3,5-2-O-(2,4-dichlorobenzyl)-D-ribofuranose-2-tone was produced by oxidizing 1-O-methyl-3,5-bis-O-(2,4-dichlorobenzyl)-D-ribofuranose,which was synthesized from hydroxyl protection and selectively removing O-2-protection of D-ribofuranose.Three oxidation methods,PDC,DMP and Albright-Goldman were studied in the paper.It was revealed that post-processing of PDC was harder to achieve with lots of by-products,at a yield of 39.6%.The DMP method was not suitable for industrialization due to the high cost,though the yield was as high as 91.8%.The Albright-Goldman method was the suitable oxidation method for the post-processing with its 52.0% yield.The product was characterized by MS,IR and 1HNMR.展开更多
文摘1-O-methyl-3,5-2-O-(2,4-dichlorobenzyl)-D-ribofuranose-2-tone was produced by oxidizing 1-O-methyl-3,5-bis-O-(2,4-dichlorobenzyl)-D-ribofuranose,which was synthesized from hydroxyl protection and selectively removing O-2-protection of D-ribofuranose.Three oxidation methods,PDC,DMP and Albright-Goldman were studied in the paper.It was revealed that post-processing of PDC was harder to achieve with lots of by-products,at a yield of 39.6%.The DMP method was not suitable for industrialization due to the high cost,though the yield was as high as 91.8%.The Albright-Goldman method was the suitable oxidation method for the post-processing with its 52.0% yield.The product was characterized by MS,IR and 1HNMR.
