摘要
以鸟苷为起始物，制备了１－乙酰氧基－２，３，５－三苯甲酰氧基－β－Ｄ－呋喃核糖（２），再利用化合物（２）与三甲基氰基硅烷反应制备了标题化合物（１）．着重研究了多种Ｌｅｗｉｓ酸（ＳｎＣｌ４、ＡｌＣｌ３、ＦｅＣｌ３、ＢＦ３·ＯＥｔ２等）对化合物（２）→（１）的反应的催化作用，同时讨论了化合物（２）与三甲基氰基硅烷的最佳配比。
O Acety1 2,3,5 tri O benzoy1 β D ribofuranose (2), was synthesized by using guanosin as a starting material. The title compound (1)was prepared from (2) and cyanotrimethylsilane. The key points of the study on the preparation of (1) from (2) were the catalytic efficiency of several kinds of Lewis acids (SnCl 4, AlCl 3, FeCl 3,BF 3·OEt 2, etc.) and the influence of molar ratio of reagents [Me 3SiCN/(2)]on the yield of (1). The synthetic method of (2) was improved.
出处
《湖北大学学报（自然科学版）》
CAS
1996年第2期155-158,共4页
Journal of Hubei University：Natural Science
