摘要
1-O-methyl-3,5-2-O-(2,4-dichlorobenzyl)-D-ribofuranose-2-tone was produced by oxidizing 1-O-methyl-3,5-bis-O-(2,4-dichlorobenzyl)-D-ribofuranose,which was synthesized from hydroxyl protection and selectively removing O-2-protection of D-ribofuranose.Three oxidation methods,PDC,DMP and Albright-Goldman were studied in the paper.It was revealed that post-processing of PDC was harder to achieve with lots of by-products,at a yield of 39.6%.The DMP method was not suitable for industrialization due to the high cost,though the yield was as high as 91.8%.The Albright-Goldman method was the suitable oxidation method for the post-processing with its 52.0% yield.The product was characterized by MS,IR and 1HNMR.
1 -O-methyl-3,5-2-O-（ 2,4-dichlorobenzyl ） -D-ribofuranose-2-tone was produced by oxidizing 1 -O-methyl-3,5-bis-O- （ 2, 4-dichlorobenzyl）-D-ribofuranose, which was synthesized from hydroxyl protection and selectively removing O-2-protection of D-ri- bofuranose. Three oxidation methods, PDC, DMP and Albright-Goldman were studied in the paper. It was revealed that post-processing of PDC was harder to achieve with lots of by-products, at a yield of 39.6%. The DMP method was not suitable for industrialization due to the high cost,though the yield was as high as 91.8%. The Albright-Goldmanmethod was the suitable oxidation method for the post-processing with its 52. 0% yield. The product was characterized by MS,IR and ^1 HNMR.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2010年第4期514-518,共5页
Chemical Research and Application
