睡眠中癫痫性电持续状态（electrical statusepil epticus during sleep，ESES）是指由睡眠诱发的接近持续棘慢波发放的一种特殊脑电现象，可出现在一系列以癫痫发作、ESES和认知损伤为共同特征的儿童癫痫综合征中，包括癫痫伴慢波睡眠...睡眠中癫痫性电持续状态（electrical statusepil epticus during sleep，ESES）是指由睡眠诱发的接近持续棘慢波发放的一种特殊脑电现象，可出现在一系列以癫痫发作、ESES和认知损伤为共同特征的儿童癫痫综合征中，包括癫痫伴慢波睡眠期持续棘慢波、获得性癫痫失语综合征、儿童良性癫痫伴中央颞区棘波及其变异型。ESES的产生机制目前尚不明确，但在多方面包括遗传学病因（GRIN2A、拷贝数变异等）、高频振荡及脑网络研究方面已取得了一定的进展。ESES相关综合征的治疗必须同时兼顾癫痫发作和ESES，应积极选择合理的抗癫痫药物或其他治疗方案，如激素等，从而最大限度地减少癫痫发作、保护认知功能。展开更多
Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases rema...Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 termborn infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function. This study was approved by the Regional Ethics Review Boards of the Changzhou Children's Hospital(approval No. 2013-001) on January 31, 2013. Informed consent was obtained from the family members of the children. The trial was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR1800016409) and the protocol version is 1.0.展开更多
Over the last few years, many studies have been published using modern network analysis of the brain. Researchers and practical doctors alike should understand this method and its results on the brain evaluation at re...Over the last few years, many studies have been published using modern network analysis of the brain. Researchers and practical doctors alike should understand this method and its results on the brain evaluation at rest, during activation and in brain disease. The studies are noninvasive and usually performed with elecroencephalographic, magnetoencephalographic, magnetic resonance imaging and diffusion tensor imaging brain recordings. Different tools for analysis have been developed, although the methods are in their early stages. The results of these analyses are of special value. Studies of these tools in schizophrenia are important because widespread and local network disturbances can be evaluated by assessing integration, segregation and several structural and functional properties. With the help of network analyses, the main findings in schizophrenia are lower optimum network organization, less efficiently wired networks, less local clustering, less hierarchical organization and signs of disconnection. There are only about twenty five relevant papers on the subject today. Only a few years of study of these methods have produced interesting results and it appears promising that the development of these methods will present important knowledge for both the preclinical signs of schizophrenia and the methods' therapeutic effects.展开更多
针对回声状态网络(Echo state network,ESN)结构设计问题,提出一种基于脑网络的分层模块化回声状态网络(Hierarchical modular echo state network,HMESN)。脑网络的拓扑结构使功能网络具有丰富的动力学特性,因此,从生物仿生学角度出发,...针对回声状态网络(Echo state network,ESN)结构设计问题,提出一种基于脑网络的分层模块化回声状态网络(Hierarchical modular echo state network,HMESN)。脑网络的拓扑结构使功能网络具有丰富的动力学特性,因此,从生物仿生学角度出发,对HMESN的储备池进行分层设计,各层级上的神经元采用小世界网络构建算法生成模块化结构,并引入层级连接。基于脑网络分层模块化的拓扑特征弱化了神经元间的耦合程度,从而使神经元的动力学特性更为丰富,在功能与结构上更接近于真实生物神经网络,有效地提高了网络处理问题的能力。采用Mackey-Glass时间序列预测和非线性系统辨识对网络进行验证,证明该网络的有效性和可行性。展开更多
文摘睡眠中癫痫性电持续状态（electrical statusepil epticus during sleep，ESES）是指由睡眠诱发的接近持续棘慢波发放的一种特殊脑电现象，可出现在一系列以癫痫发作、ESES和认知损伤为共同特征的儿童癫痫综合征中，包括癫痫伴慢波睡眠期持续棘慢波、获得性癫痫失语综合征、儿童良性癫痫伴中央颞区棘波及其变异型。ESES的产生机制目前尚不明确，但在多方面包括遗传学病因（GRIN2A、拷贝数变异等）、高频振荡及脑网络研究方面已取得了一定的进展。ESES相关综合征的治疗必须同时兼顾癫痫发作和ESES，应积极选择合理的抗癫痫药物或其他治疗方案，如激素等，从而最大限度地减少癫痫发作、保护认知功能。
基金supported by the Jiangsu Maternal and Child Health Research Project of China,No.F201612(to HXL)Changzhou Science and Technology Support Plan of China,No.CE20165027(to HXL)+1 种基金Changzhou City Planning Commission Major Science and Technology Projects of China,No.ZD201515(to HXL)Changzhou High Level Training Fund for Health Professionals of China,No.2016CZBJ028(to HXL)
文摘Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 termborn infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function. This study was approved by the Regional Ethics Review Boards of the Changzhou Children's Hospital(approval No. 2013-001) on January 31, 2013. Informed consent was obtained from the family members of the children. The trial was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR1800016409) and the protocol version is 1.0.
文摘Over the last few years, many studies have been published using modern network analysis of the brain. Researchers and practical doctors alike should understand this method and its results on the brain evaluation at rest, during activation and in brain disease. The studies are noninvasive and usually performed with elecroencephalographic, magnetoencephalographic, magnetic resonance imaging and diffusion tensor imaging brain recordings. Different tools for analysis have been developed, although the methods are in their early stages. The results of these analyses are of special value. Studies of these tools in schizophrenia are important because widespread and local network disturbances can be evaluated by assessing integration, segregation and several structural and functional properties. With the help of network analyses, the main findings in schizophrenia are lower optimum network organization, less efficiently wired networks, less local clustering, less hierarchical organization and signs of disconnection. There are only about twenty five relevant papers on the subject today. Only a few years of study of these methods have produced interesting results and it appears promising that the development of these methods will present important knowledge for both the preclinical signs of schizophrenia and the methods' therapeutic effects.
文摘针对回声状态网络(Echo state network,ESN)结构设计问题,提出一种基于脑网络的分层模块化回声状态网络(Hierarchical modular echo state network,HMESN)。脑网络的拓扑结构使功能网络具有丰富的动力学特性,因此,从生物仿生学角度出发,对HMESN的储备池进行分层设计,各层级上的神经元采用小世界网络构建算法生成模块化结构,并引入层级连接。基于脑网络分层模块化的拓扑特征弱化了神经元间的耦合程度,从而使神经元的动力学特性更为丰富,在功能与结构上更接近于真实生物神经网络,有效地提高了网络处理问题的能力。采用Mackey-Glass时间序列预测和非线性系统辨识对网络进行验证,证明该网络的有效性和可行性。
