Once thought to be a waste product of oxygen limited(anaerobic)metabolism,lactate is now known to form continuously under fully oxygenated(aerobic)conditions.Lactate shuttling between producer(driver)and consumer cell...Once thought to be a waste product of oxygen limited(anaerobic)metabolism,lactate is now known to form continuously under fully oxygenated(aerobic)conditions.Lactate shuttling between producer(driver)and consumer cells fulfills at least 3 purposes;lactate is:(1)a major energy source,(2)the major gluconeogenic precursor,and(3)a signaling molecule.The Lactate Shuttle theory is applicable to diverse fields such as sports nutrition and hydration,resuscitation from acidosis and Dengue,treatment of traumatic brain injury,maintenance of glycemia,reduction of inflammation,cardiac support in heart failure and following a myocardial infarction,and to improve cognition.Yet,dysregulated lactate shuttling disrupts metabolic flexibility,and worse,supports oncogenesis.Lactate production in cancer(the Warburg effect)is involved in all main sequela for carcinogenesis:angiogenesis,immune escape,cell migration,metastasis,and self-sufficient metabolism.The history of the tortuous path of discovery in lactate metabolism and shuttling was discussed in the 2019 American College of Sports Medicine Joseph B.Wolffe Lecture in Orlando,FL.展开更多
AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 diabetes.METHODS:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Goog...AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 diabetes.METHODS:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Google Scholar,Scopus,and Science Direct with the following terms:aerobic,anaerobic,high-intensity,resistance,exercise/training,combined with glycemic/metabolic control,glycated haemoglobin A1c(Hb A1c) and type 1diabetes.Only peer-reviewed articles in English were included published in the last 15 years.It was selected from 1999 to 2014.Glycemic control was measured with Hb A1 c.Studies with an intervention lasting at least 12 wk were included if the Hb A1 c was measured before and after the intervention.RESULTS:A total of nine articles were found,and they were published between the years of 2002-2011.The sample size was 401 diabetic youths(166 males and 235 females) with an age range of 10-19 years except one study,in which the age range was 13-30 years.Study participants were from Australia,Tunisia,Lithuania,Taiwan,Turkey,Brazilia,Belgium,Egypt and France.Four studies were aerobic-based,four were combined aerobic and anaerobic programs,and one compared aerobic exercise to anaerobic one.Available studies had insufficient evidence that any type of exercise or combined training would clearly improve the glycemic control in type 1 diabetic youth.Only three(two aerobic-based and one combined) studies could provide a significant positive change in glycemic control.CONCLUSION:The regular physical exercise has several other valuable physiological and health benefits that justify the inclusion of exercise in pediatric diabetes treatment and care.展开更多
目的分析系统性心肺康复护理对冠心病患者心肺功能及生活质量的影响。方法选取2019年1月—2020年1月在本院就诊的124例冠心病患者为研究对象,根据康复期护理方案分为对照组58例和观察组66例。对照组患者给予常规护理方案,观察组患者给...目的分析系统性心肺康复护理对冠心病患者心肺功能及生活质量的影响。方法选取2019年1月—2020年1月在本院就诊的124例冠心病患者为研究对象,根据康复期护理方案分为对照组58例和观察组66例。对照组患者给予常规护理方案,观察组患者给予系统性心肺康复护理干预。比较2组患者心肺功能[无氧阈(AT)、峰值氧脉搏、峰值氧摄取量、二氧化碳通气当量斜率(V E/V CO 2)、6 min步行试验(6MWD)]、生活质量及护理满意度。结果观察组患者干预后AT、峰值氧脉搏、峰值氧摄取量及6WMD均高于对照组患者,V E/V CO 2低于对照组,差异有统计学意义(P<0.01)。2组患者干预后生活质量各维度评分均较干预前显著改善(P<0.01),且观察组生理职能、社会功能、活力、情感职能、精神健康及总体健康评分均显著高于对照组(P<0.01)。观察组患者对护理的总满意率为98.48%,显著高于对照组患者的86.20%(P<0.01)。结论冠心病患者康复期间应用系统性的心肺康复护理干预安全、有效,能改善患者心肺功能、运动耐力,提高患者生活质量。展开更多
文摘Once thought to be a waste product of oxygen limited(anaerobic)metabolism,lactate is now known to form continuously under fully oxygenated(aerobic)conditions.Lactate shuttling between producer(driver)and consumer cells fulfills at least 3 purposes;lactate is:(1)a major energy source,(2)the major gluconeogenic precursor,and(3)a signaling molecule.The Lactate Shuttle theory is applicable to diverse fields such as sports nutrition and hydration,resuscitation from acidosis and Dengue,treatment of traumatic brain injury,maintenance of glycemia,reduction of inflammation,cardiac support in heart failure and following a myocardial infarction,and to improve cognition.Yet,dysregulated lactate shuttling disrupts metabolic flexibility,and worse,supports oncogenesis.Lactate production in cancer(the Warburg effect)is involved in all main sequela for carcinogenesis:angiogenesis,immune escape,cell migration,metastasis,and self-sufficient metabolism.The history of the tortuous path of discovery in lactate metabolism and shuttling was discussed in the 2019 American College of Sports Medicine Joseph B.Wolffe Lecture in Orlando,FL.
文摘AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 diabetes.METHODS:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Google Scholar,Scopus,and Science Direct with the following terms:aerobic,anaerobic,high-intensity,resistance,exercise/training,combined with glycemic/metabolic control,glycated haemoglobin A1c(Hb A1c) and type 1diabetes.Only peer-reviewed articles in English were included published in the last 15 years.It was selected from 1999 to 2014.Glycemic control was measured with Hb A1 c.Studies with an intervention lasting at least 12 wk were included if the Hb A1 c was measured before and after the intervention.RESULTS:A total of nine articles were found,and they were published between the years of 2002-2011.The sample size was 401 diabetic youths(166 males and 235 females) with an age range of 10-19 years except one study,in which the age range was 13-30 years.Study participants were from Australia,Tunisia,Lithuania,Taiwan,Turkey,Brazilia,Belgium,Egypt and France.Four studies were aerobic-based,four were combined aerobic and anaerobic programs,and one compared aerobic exercise to anaerobic one.Available studies had insufficient evidence that any type of exercise or combined training would clearly improve the glycemic control in type 1 diabetic youth.Only three(two aerobic-based and one combined) studies could provide a significant positive change in glycemic control.CONCLUSION:The regular physical exercise has several other valuable physiological and health benefits that justify the inclusion of exercise in pediatric diabetes treatment and care.
文摘目的分析系统性心肺康复护理对冠心病患者心肺功能及生活质量的影响。方法选取2019年1月—2020年1月在本院就诊的124例冠心病患者为研究对象,根据康复期护理方案分为对照组58例和观察组66例。对照组患者给予常规护理方案,观察组患者给予系统性心肺康复护理干预。比较2组患者心肺功能[无氧阈(AT)、峰值氧脉搏、峰值氧摄取量、二氧化碳通气当量斜率(V E/V CO 2)、6 min步行试验(6MWD)]、生活质量及护理满意度。结果观察组患者干预后AT、峰值氧脉搏、峰值氧摄取量及6WMD均高于对照组患者,V E/V CO 2低于对照组,差异有统计学意义(P<0.01)。2组患者干预后生活质量各维度评分均较干预前显著改善(P<0.01),且观察组生理职能、社会功能、活力、情感职能、精神健康及总体健康评分均显著高于对照组(P<0.01)。观察组患者对护理的总满意率为98.48%,显著高于对照组患者的86.20%(P<0.01)。结论冠心病患者康复期间应用系统性的心肺康复护理干预安全、有效,能改善患者心肺功能、运动耐力,提高患者生活质量。
