Micro-flow channel is basic functional component of microfluidic chip,and every step-forward of its construction technique has been receiving concern all over the world.This article presents a not-complicated but flex...Micro-flow channel is basic functional component of microfluidic chip,and every step-forward of its construction technique has been receiving concern all over the world.This article presents a not-complicated but flexible method for fabrication of micro-flow channels.This method mainly utilizes the conventional molding capability of polydimethylsiloxane(PDMS) and widespread commercial microwires as templates.We have fabricated out some conventional types of microchannels with different topological shapes,as examples for the demonstration of this flexible fabrication route which was not dependent on the stringent demands of photolithographical or microelectromechanical system(MEMS) techniques.The smooth surface,high-intensity,and high flexibility of the wires made it possible to create many types of topological structures of the two-dimensional or three-dimensional microchannel or channel array.The geometric shape of the cross-section of thus forming microchannel in PDMS was the negative of that of embedded-in microwire,in high-fidelity if suitable measures were taken.More-over,such a microchannel fabrication process can easily integrate the conductivity and low resistivity of the metal wire to create micro-flow devices that are suitable for the electromagnetic control of liquid or the temperature regulation in the microchannel.Furthermore some preliminary optical analysis was provided for the observation of thus forming rounded microchannel.Based on this molding strategy,we even made some prototypes for functional microflow application,such as microsolenoids chip and temperature control gadgets.And an experiment of forming a droplet in the cross channel further confirmed the feasibility and applicability of this flexible microchannel forming technique.展开更多
Polyurethane based on polypropylene glycol(PPG) and TDI using 3,3\|dichloride\|4,4\|methylenedianiline(MOCA) as the crosslinker is presented for the first time to fabricate molecular stamps(PU stamps) for the synt...Polyurethane based on polypropylene glycol(PPG) and TDI using 3,3\|dichloride\|4,4\|methylenedianiline(MOCA) as the crosslinker is presented for the first time to fabricate molecular stamps(PU stamps) for the synthesis of DNA microarray with contact procedure. The predictability of the process is achieved by utilizing commercially available starting materials. SEM analysis of the morphology of PU stamps and photoresist motherboard showed that PU elastomer could replicate subtly the motherboards patterns with a high fidelity. It was proved from the contact angle measurement that PU stamps surface has a good affinity with acetonitrile, which guarantee the well\|distribution of DNA monomers on patterned stamps. Laser confocal fluorescence microscopy images of oligonucleotide arrays confirm that polyurethane is an excellent material for molecular stamps.展开更多
Introduction During the last two decades,organic light-emitting diodes (OLED) have attracted considerable interest owing to their promising applications by replacing cathode ray tubes (CRTs) or liquid crystal displays...Introduction During the last two decades,organic light-emitting diodes (OLED) have attracted considerable interest owing to their promising applications by replacing cathode ray tubes (CRTs) or liquid crystal displays (LCDs).展开更多
基金Supported by the Key Project for International Science and Technology Collaboration of the Ministry of Science & Technology (Grant No. 2005DFA00190)partially supported by "111 Project" (B06023)Chongqing University Post-graduates' Science and Innovation Fund (No.200707A1A0110248)
文摘Micro-flow channel is basic functional component of microfluidic chip,and every step-forward of its construction technique has been receiving concern all over the world.This article presents a not-complicated but flexible method for fabrication of micro-flow channels.This method mainly utilizes the conventional molding capability of polydimethylsiloxane(PDMS) and widespread commercial microwires as templates.We have fabricated out some conventional types of microchannels with different topological shapes,as examples for the demonstration of this flexible fabrication route which was not dependent on the stringent demands of photolithographical or microelectromechanical system(MEMS) techniques.The smooth surface,high-intensity,and high flexibility of the wires made it possible to create many types of topological structures of the two-dimensional or three-dimensional microchannel or channel array.The geometric shape of the cross-section of thus forming microchannel in PDMS was the negative of that of embedded-in microwire,in high-fidelity if suitable measures were taken.More-over,such a microchannel fabrication process can easily integrate the conductivity and low resistivity of the metal wire to create micro-flow devices that are suitable for the electromagnetic control of liquid or the temperature regulation in the microchannel.Furthermore some preliminary optical analysis was provided for the observation of thus forming rounded microchannel.Based on this molding strategy,we even made some prototypes for functional microflow application,such as microsolenoids chip and temperature control gadgets.And an experiment of forming a droplet in the cross channel further confirmed the feasibility and applicability of this flexible microchannel forming technique.
文摘Polyurethane based on polypropylene glycol(PPG) and TDI using 3,3\|dichloride\|4,4\|methylenedianiline(MOCA) as the crosslinker is presented for the first time to fabricate molecular stamps(PU stamps) for the synthesis of DNA microarray with contact procedure. The predictability of the process is achieved by utilizing commercially available starting materials. SEM analysis of the morphology of PU stamps and photoresist motherboard showed that PU elastomer could replicate subtly the motherboards patterns with a high fidelity. It was proved from the contact angle measurement that PU stamps surface has a good affinity with acetonitrile, which guarantee the well\|distribution of DNA monomers on patterned stamps. Laser confocal fluorescence microscopy images of oligonucleotide arrays confirm that polyurethane is an excellent material for molecular stamps.
基金This work was supported by the National Science Support Program （2006BAE04B05-3）MOE Program for Changjiang Scholars and Innovative Research Team （grant No. 0629）+2 种基金National Science Foundation of China （grant No. 50505037）863 Hi-Teeh Program （grant No. 2006AA04Z322 ）＂Qing Lan＂ Talent Engineering Funds by Lanzhou Jiaotong University.
文摘Introduction During the last two decades,organic light-emitting diodes (OLED) have attracted considerable interest owing to their promising applications by replacing cathode ray tubes (CRTs) or liquid crystal displays (LCDs).
