Objective:To evaluate the performance of interferon gamma release assays and tuberculin skin test in Bacillus Calmette-Guerin vaccinated young children.Methods:A cross-sectional study was conducted in healthy children...Objective:To evaluate the performance of interferon gamma release assays and tuberculin skin test in Bacillus Calmette-Guerin vaccinated young children.Methods:A cross-sectional study was conducted in healthy children younger than 5 years who were recently diagnosed with tuberculosis or had recent exposure to active tuberculosis.QuantiFERON-TB Gold,T-SPOT.TB and tuberculin skin test were performed in each patient.Results:Of the 60 children,median age 3.3 years,17 had tuberculosis and 43 had recent tuberculosis exposure.Overall,15(25.0%)children had tuberculin skin test reaction≥10 mm;8(13.3%)were positive by QuantiFERON-TB Gold In-Tube test,and 12(20.0%)by T-SPOT.TB.Nineteen(31.7%)children had at least one positive test.There was a moderate agreement between interferon gamma release assays and tuberculin skin test.Conclusions:The positive rates of interferon gamma release assays and tuberculin skin test were low in young children who were infected with tuberculosis,supporting the management strategy of not testing children younger than 5 years.展开更多
Local heat transfer and skin friction around the tube perimeter of coils were studied in airflow. The heat transfer experiments were performed with two different coils D/d = 23 and 15.6, and skin friction experiments ...Local heat transfer and skin friction around the tube perimeter of coils were studied in airflow. The heat transfer experiments were performed with two different coils D/d = 23 and 15.6, and skin friction experiments were performed with three different coils D/d = 25, 13.3 and 6.67 In the wide range of Re number from 4×103 till 105 . Variation of the local heat transfer around the perimeter and along the tube was defined. The behavior of the shear stresses at the wall and of the flow modes were studied. Investigations of the heat transfer indicated that with the increase of D/d the difference between heat transfer in the initial thermal section and the stabilized heat transfer increases. Investigations of the shear stress and its fluctuations indicated that, in large-curvature coils, the transition from laminar-vortex flow to turbulent flow around the tube perimeter takes place at different values of Re. In the region of the external generatrix of the bend, the transition occurs at smaller Re, whereas展开更多
基金supported by the Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok,Thailand,[Grant Number(IO)R016032002]Oxford Immunotec and Biomed diagnostics(Thailand)provided the T-SPOT.TB test kit
文摘Objective:To evaluate the performance of interferon gamma release assays and tuberculin skin test in Bacillus Calmette-Guerin vaccinated young children.Methods:A cross-sectional study was conducted in healthy children younger than 5 years who were recently diagnosed with tuberculosis or had recent exposure to active tuberculosis.QuantiFERON-TB Gold,T-SPOT.TB and tuberculin skin test were performed in each patient.Results:Of the 60 children,median age 3.3 years,17 had tuberculosis and 43 had recent tuberculosis exposure.Overall,15(25.0%)children had tuberculin skin test reaction≥10 mm;8(13.3%)were positive by QuantiFERON-TB Gold In-Tube test,and 12(20.0%)by T-SPOT.TB.Nineteen(31.7%)children had at least one positive test.There was a moderate agreement between interferon gamma release assays and tuberculin skin test.Conclusions:The positive rates of interferon gamma release assays and tuberculin skin test were low in young children who were infected with tuberculosis,supporting the management strategy of not testing children younger than 5 years.
文摘Local heat transfer and skin friction around the tube perimeter of coils were studied in airflow. The heat transfer experiments were performed with two different coils D/d = 23 and 15.6, and skin friction experiments were performed with three different coils D/d = 25, 13.3 and 6.67 In the wide range of Re number from 4×103 till 105 . Variation of the local heat transfer around the perimeter and along the tube was defined. The behavior of the shear stresses at the wall and of the flow modes were studied. Investigations of the heat transfer indicated that with the increase of D/d the difference between heat transfer in the initial thermal section and the stabilized heat transfer increases. Investigations of the shear stress and its fluctuations indicated that, in large-curvature coils, the transition from laminar-vortex flow to turbulent flow around the tube perimeter takes place at different values of Re. In the region of the external generatrix of the bend, the transition occurs at smaller Re, whereas
