Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This stud...Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side.展开更多
A bioinspired autopilot is presented, in which body saccadic and intersaceadic systems are combined. This autopilot en- ables a simulated hovercraft to travel along corridors comprising L-junctions, U-shaped and S-sha...A bioinspired autopilot is presented, in which body saccadic and intersaceadic systems are combined. This autopilot en- ables a simulated hovercraft to travel along corridors comprising L-junctions, U-shaped and S-shaped turns, relying on mini- realistic motion vision cues alone without measuring its speed or distance from walls, in much the same way as flies and bees manage their flight in similar situations. The saccadic system responsible for avoiding frontal collisions triggers yawing body saccades with appropriately quantified angles based simply on a few local optic flow measurements, giving the angle of inci- dence with respect to a frontal wall. The simulated robot negotiates stiff bends by triggering body saccades to realign its tra- jectory, thus traveling parallel with the wall along a corridor comprising sharp turns. Direct comparison shows that the per- formance of this new body saccade-based autopilot closely resembles the behavior of a fly using similar body saccade strategy when flying along a corridor with an S-shaped turn, despite the huge differences in terms of the inertia.展开更多
There is an impressive scarcity of quantitative models of the clock patterns in the brain. We propose a mesoscopic approach, i.e. neither a description at single neuron level, nor at systemic level/too coarse granular...There is an impressive scarcity of quantitative models of the clock patterns in the brain. We propose a mesoscopic approach, i.e. neither a description at single neuron level, nor at systemic level/too coarse granularity, of the time perception at the time of the saccade. This model uses functional pathway knowledge and is inspired by, and integrates, recent findings in both psychophysics and neurophysiology. Perceived time delays in the perisaccadic window are shown numerically consistent with recent experimental measures. Our model provides explanation for several experimental outcomes on saccades, estimates popu-lation variance of the error in time perception and represent a meaningful example for bridging psychophysics and neurophysiology. Finally we found that the insights into information processing during saccadic events lead to considerations on engineering exploitation of the underlying phenomena.展开更多
基金supported by grants from National Key Research and Development Program of China-part3(2020YFC2005203)Capital's Funds for Health Improvement and Research(No.2022-1-2023).
文摘Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side.
文摘A bioinspired autopilot is presented, in which body saccadic and intersaceadic systems are combined. This autopilot en- ables a simulated hovercraft to travel along corridors comprising L-junctions, U-shaped and S-shaped turns, relying on mini- realistic motion vision cues alone without measuring its speed or distance from walls, in much the same way as flies and bees manage their flight in similar situations. The saccadic system responsible for avoiding frontal collisions triggers yawing body saccades with appropriately quantified angles based simply on a few local optic flow measurements, giving the angle of inci- dence with respect to a frontal wall. The simulated robot negotiates stiff bends by triggering body saccades to realign its tra- jectory, thus traveling parallel with the wall along a corridor comprising sharp turns. Direct comparison shows that the per- formance of this new body saccade-based autopilot closely resembles the behavior of a fly using similar body saccade strategy when flying along a corridor with an S-shaped turn, despite the huge differences in terms of the inertia.
文摘There is an impressive scarcity of quantitative models of the clock patterns in the brain. We propose a mesoscopic approach, i.e. neither a description at single neuron level, nor at systemic level/too coarse granularity, of the time perception at the time of the saccade. This model uses functional pathway knowledge and is inspired by, and integrates, recent findings in both psychophysics and neurophysiology. Perceived time delays in the perisaccadic window are shown numerically consistent with recent experimental measures. Our model provides explanation for several experimental outcomes on saccades, estimates popu-lation variance of the error in time perception and represent a meaningful example for bridging psychophysics and neurophysiology. Finally we found that the insights into information processing during saccadic events lead to considerations on engineering exploitation of the underlying phenomena.
