摘要
帕金森病(Parkinson′s disease)是一种常见的中枢神经系统变性病,其主要临床表现为运动迟缓、静止性震颤、肌强直及姿势步态异常。眼球运动检查是神经系统体检的重要组成部分,进行性核上性麻痹、多系统萎缩等帕金森综合征均可出现特定的眼球运动障碍形式,甚至可以作为疾病诊断依据之一。近年来研究发现,帕金森病的眼球运动障碍也有其特征性,可能在帕金森病早期诊断、进展及鉴别诊断中发挥重要作用。2015年世界运动障碍协会帕金森病诊断标准提出,出现持续凝视诱发的眼震等眼球运动障碍可作为帕金森病的排除标准。我们就帕金森病眼球运动障碍的表现、检测方法及临床意义做一综述。
Parkinson′s disease (PD) is a common neurodegenerative disease characterized by bradykinesia, resting tremor, muscle rigidity, and abnormal gait posture. Ocular motor function test plays an important part in neurological examinations. It has been widely accepted that specific ocular motor patterns contribute to diagnosis of Parkinsonian syndrome including progressive supranuclear palsy and multiple system atrophy. However, recent studies have shown that patients of PD may also exhibit specific eye movement disorders, which will be helpful in the early diagnosis, evaluation and differential diagnosis of PD. In 2015, the Movement Disorder Society clinical diagnostic criteria for Parkinson′s disease suggested that sustained staring evoked nystagmus could be used as an exclusive criterion for PD. The clinical features, detection methods and clinical significance of oculomotor dysfunction in PD are reviewed in this article.
作者
陈亚瑟
周小婷
孙启英
徐倩
郭纪锋
唐北沙
严新翔
Chen Yase;Zhou Xiaoting;Sun Qiying;Xu Qian;Guo Jifeng;Tang Beisha;Yan Xinxiang(Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008, China;Department of Geriatric Neurology,Xiangya Hospital,Central South University,Changsha 410008, China;National Clinical Research Genter for Geriatric Diseases (XIANGYA),Changsha 410008,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2019年第2期143-146,共4页
Chinese Journal of Neurology
基金
国家自然科学基金资助项目(81430023,81401059)
国家重点研发计划项目(2016YFC1306000,2017YFC0909100).
关键词
帕金森病
眼球运动障碍
眼扫视
Parkinson disease
Ocular motility disorders
Saccades
