目的:比较吻合器痔上黏膜环切术(PPH)联合痔切除术与开放式外剥内扎术治疗痔疮的效果。方法:选取2017年2月至2018年1月广州医科大学附属顺德医院收治的环状混合痔患者80例,按手术方式分为对照组(n=40)和观察组(n=40),分别采用开放式外...目的:比较吻合器痔上黏膜环切术(PPH)联合痔切除术与开放式外剥内扎术治疗痔疮的效果。方法:选取2017年2月至2018年1月广州医科大学附属顺德医院收治的环状混合痔患者80例,按手术方式分为对照组(n=40)和观察组(n=40),分别采用开放式外剥内扎术和PPH联合痔切除术进行治疗。记录两组手术时间、术中出血量、术后24 h视觉模拟评分(VAS)、住院时间、患者满意度、术后恢复情况及并发症发生情况。结果:观察组患者手术时间、术中出血量、术后24 h VAS评分、住院时间均优于对照组(均P<0.05)。观察组患者术后满意度高于对照组,并发症发生率低于对照组(均P<0.05)。结论:PPH联合痔切除术治疗痔疮具有较好的临床疗效。展开更多
Objective： Vigna subterranea is widely consumed as a traditional staple food in Nigeria and some West African countries. The ethanolic seed extract of V. subterranea （EEVS） was investigated for its gastroprotective...Objective： Vigna subterranea is widely consumed as a traditional staple food in Nigeria and some West African countries. The ethanolic seed extract of V. subterranea （EEVS） was investigated for its gastroprotective effects on aspirin plus pylorus ligation-induced gastric ulcerated rats using an in vivo assay. Methods： Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 using aspirin plus pylorus ligation. Rats in Group I were orally pretreated with 3% Tween 80 only as normal control. Groups 2 to 5 were pretreated with 3% Tween B0 （ulcer group）, 20 mg/kg of omeprazole （positive group）, and 200 and 400 mg/kg of EEVS （experimental groups）, respectively, once daily for 21 days before ulcer induction. Parameters including those for gastric secretions, ulcerated areas and gastric wall histology were assessed. Levels of superoxide dismutase （SOD）, glutathione peroxidase （GPx）, and malondialdehyde （MDA） in the gastric tissue homogenate were also determined. Results： Pretreatment with EEVS significantly （P 〈 0.05） reduced the ulcer index, gastric volume and total acidity in rats with aspirin plus pylorus ligation-induced ulcer. The pH and mucus of gastric content increased significantly （P 〈 0.05） while the levels of SOD and GPx were observed to be elevated with a reduced amount of MDA. Significant severe gastric mucosal injury was exhibited in the ulcer group and EEVS or omeprazole offered significant （P〈0.05） protection against mucosal ulceration. Histologically, the gastric submucosal layer showed remarkable decrease in edema and leucocytes infiltration compared with ulcer group. Conclusion： The study suggests that EEVS offered a protective action against aspirin plus pylorus ligationinduced gastric ulcers in Wistar rats. The protective effect might be mediated via antisecretory, cytopro- tective and antioxidative mechanisms.展开更多
文摘目的:比较吻合器痔上黏膜环切术(PPH)联合痔切除术与开放式外剥内扎术治疗痔疮的效果。方法:选取2017年2月至2018年1月广州医科大学附属顺德医院收治的环状混合痔患者80例,按手术方式分为对照组(n=40)和观察组(n=40),分别采用开放式外剥内扎术和PPH联合痔切除术进行治疗。记录两组手术时间、术中出血量、术后24 h视觉模拟评分(VAS)、住院时间、患者满意度、术后恢复情况及并发症发生情况。结果:观察组患者手术时间、术中出血量、术后24 h VAS评分、住院时间均优于对照组(均P<0.05)。观察组患者术后满意度高于对照组,并发症发生率低于对照组(均P<0.05)。结论:PPH联合痔切除术治疗痔疮具有较好的临床疗效。
文摘Objective： Vigna subterranea is widely consumed as a traditional staple food in Nigeria and some West African countries. The ethanolic seed extract of V. subterranea （EEVS） was investigated for its gastroprotective effects on aspirin plus pylorus ligation-induced gastric ulcerated rats using an in vivo assay. Methods： Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 using aspirin plus pylorus ligation. Rats in Group I were orally pretreated with 3% Tween 80 only as normal control. Groups 2 to 5 were pretreated with 3% Tween B0 （ulcer group）, 20 mg/kg of omeprazole （positive group）, and 200 and 400 mg/kg of EEVS （experimental groups）, respectively, once daily for 21 days before ulcer induction. Parameters including those for gastric secretions, ulcerated areas and gastric wall histology were assessed. Levels of superoxide dismutase （SOD）, glutathione peroxidase （GPx）, and malondialdehyde （MDA） in the gastric tissue homogenate were also determined. Results： Pretreatment with EEVS significantly （P 〈 0.05） reduced the ulcer index, gastric volume and total acidity in rats with aspirin plus pylorus ligation-induced ulcer. The pH and mucus of gastric content increased significantly （P 〈 0.05） while the levels of SOD and GPx were observed to be elevated with a reduced amount of MDA. Significant severe gastric mucosal injury was exhibited in the ulcer group and EEVS or omeprazole offered significant （P〈0.05） protection against mucosal ulceration. Histologically, the gastric submucosal layer showed remarkable decrease in edema and leucocytes infiltration compared with ulcer group. Conclusion： The study suggests that EEVS offered a protective action against aspirin plus pylorus ligationinduced gastric ulcers in Wistar rats. The protective effect might be mediated via antisecretory, cytopro- tective and antioxidative mechanisms.
