The caprice for the study came from an indigenous designed instructional board for teaching learners in nursery/primary schools (2 - 10 years) and the task whose overall topic is the reminiscence, retention of visuals...The caprice for the study came from an indigenous designed instructional board for teaching learners in nursery/primary schools (2 - 10 years) and the task whose overall topic is the reminiscence, retention of visuals aid use in the pedagogy. The study is to appraise the opinion of toddlers/teachers about the helpfulness of 3D-visuals (ergonomic board);the clarity of the intended functions of the 3D-visuals in the toddler’s lessons instruction and support from the producers in using them;and why visuals (conventional visual aids) in schoolroom instruction are misjudged/misinterpreted;their view about the functions in specific (conventional visuals) for the instruction pedagogy;and other sources of visuals provided other than the lesson’s instruction. Four nursery/primary schools participated in the study. Seventy-two (72) toddler’s/teachers participated in the study. The study examined using quantitative and qualitative approach for statistical analysis (using pie-chart and histogram). The findings suggested that the aspects of visuals items selected for comment and description are to some extent circumscribed by toddler’s learners’ linguistic resources. Understandably, the point made by researchers referred that visuals often fail to support learning as effectively as they might because they are not regarded as a full-fledged information mode that requires the same careful processing as verbal text, is borne out by the findings. Recommendation, the accountability is above all on producers of kid’s instructional materials: authors, editors, designers and illustrators of the materials. The implication of this is that toddlers’ instructional materials should, as in the case of illustrated books include both an overt explanation of the overall philosophy toward visuals and overview of their use.展开更多
This study aims to reveal the occurrence and origin of typical groundwater with high arsenic and fluoride concentrations in the loess area of the Guanzhong Basin—a Neogene faulted basin.Key findings are as follows:(1...This study aims to reveal the occurrence and origin of typical groundwater with high arsenic and fluoride concentrations in the loess area of the Guanzhong Basin—a Neogene faulted basin.Key findings are as follows:(1)Groundwater samples with high arsenic and fluoride concentrations collected from the loess area and the terraces of the Weihe River accounted for 26%and 30%,respectively,of the total samples,with primary hydrochemical type identified as HCO_(3)-Na.The karst and sand areas exhibit relatively high groundwater quality,serving as preferred sources for water supply.It is recommended that local governments fully harness groundwater in these areas;(2)groundwater with high arsenic and fluoride concentrations in the loess area and the alluvial plain of rivers in Dali County is primarily distributed within the Guanzhong Basin,which represents the drainage zone of groundwater;(3)arsenic and fluoride in groundwater originate principally from natural and anthropogenic sources;(4)the human health risk assessments reveal that long-term intake of groundwater with high arsenic and fluoride concentrations pose cancer or non-cancer risks,which are more serious to kids compared to adults.This study provides a theoretical basis for the prevention and treatment of groundwater with high arsenic and fluoride concentrations in loess areas.展开更多
The objective of this study was to determine the effect of dietary supplementation of b-hydroxybutyric acid(BHBA)on performance,nutrient digestibility,organ development,and serum composition in earlyweaned goat kids.S...The objective of this study was to determine the effect of dietary supplementation of b-hydroxybutyric acid(BHBA)on performance,nutrient digestibility,organ development,and serum composition in earlyweaned goat kids.Sixty-four goat kids at 30 d of age were assigned to 4 treatments in a completely randomized design:1)control(basal diet);2)low(basal diet with 3 g/d per animal BHBA);3)medium(basal diet with 6 g/d per animal BHBA;and 4)high(basal diet with 9 g/d per animal BHBA).Subsequently,48(6 kids per treatment)goat kids were randomly selected and slaughtered at 60 and 90 d of age.Compared with the control group,BHBA at low and high doses increased body weight(P<0.05),average daily gain(P<0.01),and average daily starter intake(P<0.01).The BHBA improved organ development,especially at the lowest dose(P<0.01).The digestibility of dry matter and crude protein increased with age(P<0.05).However,BHBA did not affect nutrient digestibility.Compared with the control group,serum ceruloplasmin increased(P<0.05)with high BHBA level at 90 d of age.However,the serum creatinine(P<0.05)increased over time but was not affected by BHBA.The serum total antioxidant capacity and superoxide dismutase decreased with the high dose of BHBA at 90 d of age(P<0.01).In contrast,the serum glutathione peroxidase and malondialdehyde increased with the high doses of BHBA(P<0.01).Overall,low doses of BHBA were positive for growth performance,organ development,and health status against weaning stress.Whereas high doses of BHBA in the long term could negatively affect antioxidant status.展开更多
Zinc supplementation in the diet of goats affects pancreas development in offspring.However,the impact of maternal inorganic and organic zinc supplementation in offspring is poorly defined.In this study,14 late-pregna...Zinc supplementation in the diet of goats affects pancreas development in offspring.However,the impact of maternal inorganic and organic zinc supplementation in offspring is poorly defined.In this study,14 late-pregnant goats were assigned at random to the zinc sulfate group(ZnSO_(4),n=7)and the zinc-glycine chelate group(Zn-Gly,n=7),respectively.Serum samples and pancreas tissue were collected from kids whose mothers were fed ZnSO_(4)and Zn-Gly at the late pregnancy,respectively.Histologic examination showed no morphologic differences between the 2 groups.Pancreatic zinc content in kids tended to be increased when replacing ZnSO_(4)with Zn-Gly.The serum insulin concentration was greater and glucagon less in the Zn-Gly group when compared to the ZnSO_(4)group.The activities of lipase and chymotrypsin were enhanced when replacing ZnSO_(4)with Zn-Gly.Proteomics results showed that 234 proteins were differentially expressed between the 2 groups,some of which were associated with the secretion of insulin,enzyme activity and signal transduction.The results suggested that supply of dietary Zn-Gly to goats during late pregnancy promoted pancreatic function in offspring compared with dietary ZnSO_(4)supplementation.This provides new information about pancreatic function when supplementing different zinc sources in the diets of late pregnant goats.展开更多
Dear Editor,Anaplastic lymphoma kinase(ALK)rearrangement is a key driver gene in non-small cell lung cancer(NSCLC),and the effectiveness of targeted therapies directed at ALK fusion has been confirmed.1 However,the ac...Dear Editor,Anaplastic lymphoma kinase(ALK)rearrangement is a key driver gene in non-small cell lung cancer(NSCLC),and the effectiveness of targeted therapies directed at ALK fusion has been confirmed.1 However,the activity of ALK-tyrosine kinase inhibitors(ALK-TKIs)against rare ALK rearrangements is variable,with limited clinical evidence.Here,we reported the case of a novel kinase D interacting substrate 220(KIDINS220)-ALK fusion that showed favorable response to alectinib.展开更多
Using 2-3 weeks kid abomasums as materials, the ultrasound intensity, extracting time, NaCl concentration and pH valuein extracting solution and ratio of abomasums to extracting solution were studied by ultrasonic met...Using 2-3 weeks kid abomasums as materials, the ultrasound intensity, extracting time, NaCl concentration and pH valuein extracting solution and ratio of abomasums to extracting solution were studied by ultrasonic method. The resultsshowed that the main factor affecting kid rennet activity during extraction was ultrasound intensity, and then NaClconcentration, extracting time and ratio of abomasums to extracting solution in order. Kid rennet activity reached peakwith ultrasound intensity 30 W cm-2, extraction time 40 min, NaCl concentration 8%, pH value 3.0, ratio of abomasums toextracting solution 1:15.展开更多
文摘The caprice for the study came from an indigenous designed instructional board for teaching learners in nursery/primary schools (2 - 10 years) and the task whose overall topic is the reminiscence, retention of visuals aid use in the pedagogy. The study is to appraise the opinion of toddlers/teachers about the helpfulness of 3D-visuals (ergonomic board);the clarity of the intended functions of the 3D-visuals in the toddler’s lessons instruction and support from the producers in using them;and why visuals (conventional visual aids) in schoolroom instruction are misjudged/misinterpreted;their view about the functions in specific (conventional visuals) for the instruction pedagogy;and other sources of visuals provided other than the lesson’s instruction. Four nursery/primary schools participated in the study. Seventy-two (72) toddler’s/teachers participated in the study. The study examined using quantitative and qualitative approach for statistical analysis (using pie-chart and histogram). The findings suggested that the aspects of visuals items selected for comment and description are to some extent circumscribed by toddler’s learners’ linguistic resources. Understandably, the point made by researchers referred that visuals often fail to support learning as effectively as they might because they are not regarded as a full-fledged information mode that requires the same careful processing as verbal text, is borne out by the findings. Recommendation, the accountability is above all on producers of kid’s instructional materials: authors, editors, designers and illustrators of the materials. The implication of this is that toddlers’ instructional materials should, as in the case of illustrated books include both an overt explanation of the overall philosophy toward visuals and overview of their use.
基金funded by the ministry-province cooperation-based pilot project entitled A Technological System for Ecological Remediation Evaluation of Open-Pit Mines initiated by the Ministry of Natural Resources in 2023(2023-03)survey projects of the Land and Resources Investigation Program([2023]06-03-04,1212010634713)a key R&D projects of Shaanxi Province in 2023(2023ZDLSF-63)。
文摘This study aims to reveal the occurrence and origin of typical groundwater with high arsenic and fluoride concentrations in the loess area of the Guanzhong Basin—a Neogene faulted basin.Key findings are as follows:(1)Groundwater samples with high arsenic and fluoride concentrations collected from the loess area and the terraces of the Weihe River accounted for 26%and 30%,respectively,of the total samples,with primary hydrochemical type identified as HCO_(3)-Na.The karst and sand areas exhibit relatively high groundwater quality,serving as preferred sources for water supply.It is recommended that local governments fully harness groundwater in these areas;(2)groundwater with high arsenic and fluoride concentrations in the loess area and the alluvial plain of rivers in Dali County is primarily distributed within the Guanzhong Basin,which represents the drainage zone of groundwater;(3)arsenic and fluoride in groundwater originate principally from natural and anthropogenic sources;(4)the human health risk assessments reveal that long-term intake of groundwater with high arsenic and fluoride concentrations pose cancer or non-cancer risks,which are more serious to kids compared to adults.This study provides a theoretical basis for the prevention and treatment of groundwater with high arsenic and fluoride concentrations in loess areas.
基金National Natural Science Foundation of China(31872385)the National Key R&D Program Projects(2018YFD0501902)。
文摘The objective of this study was to determine the effect of dietary supplementation of b-hydroxybutyric acid(BHBA)on performance,nutrient digestibility,organ development,and serum composition in earlyweaned goat kids.Sixty-four goat kids at 30 d of age were assigned to 4 treatments in a completely randomized design:1)control(basal diet);2)low(basal diet with 3 g/d per animal BHBA);3)medium(basal diet with 6 g/d per animal BHBA;and 4)high(basal diet with 9 g/d per animal BHBA).Subsequently,48(6 kids per treatment)goat kids were randomly selected and slaughtered at 60 and 90 d of age.Compared with the control group,BHBA at low and high doses increased body weight(P<0.05),average daily gain(P<0.01),and average daily starter intake(P<0.01).The BHBA improved organ development,especially at the lowest dose(P<0.01).The digestibility of dry matter and crude protein increased with age(P<0.05).However,BHBA did not affect nutrient digestibility.Compared with the control group,serum ceruloplasmin increased(P<0.05)with high BHBA level at 90 d of age.However,the serum creatinine(P<0.05)increased over time but was not affected by BHBA.The serum total antioxidant capacity and superoxide dismutase decreased with the high dose of BHBA at 90 d of age(P<0.01).In contrast,the serum glutathione peroxidase and malondialdehyde increased with the high doses of BHBA(P<0.01).Overall,low doses of BHBA were positive for growth performance,organ development,and health status against weaning stress.Whereas high doses of BHBA in the long term could negatively affect antioxidant status.
基金The authors wish to acknowledge the financial support received from the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant NO.XDA 26040304)Natural Science Foundation of Hunan Province(2020JJ5634)National Natural Science Foundation of China(31760678).
文摘Zinc supplementation in the diet of goats affects pancreas development in offspring.However,the impact of maternal inorganic and organic zinc supplementation in offspring is poorly defined.In this study,14 late-pregnant goats were assigned at random to the zinc sulfate group(ZnSO_(4),n=7)and the zinc-glycine chelate group(Zn-Gly,n=7),respectively.Serum samples and pancreas tissue were collected from kids whose mothers were fed ZnSO_(4)and Zn-Gly at the late pregnancy,respectively.Histologic examination showed no morphologic differences between the 2 groups.Pancreatic zinc content in kids tended to be increased when replacing ZnSO_(4)with Zn-Gly.The serum insulin concentration was greater and glucagon less in the Zn-Gly group when compared to the ZnSO_(4)group.The activities of lipase and chymotrypsin were enhanced when replacing ZnSO_(4)with Zn-Gly.Proteomics results showed that 234 proteins were differentially expressed between the 2 groups,some of which were associated with the secretion of insulin,enzyme activity and signal transduction.The results suggested that supply of dietary Zn-Gly to goats during late pregnancy promoted pancreatic function in offspring compared with dietary ZnSO_(4)supplementation.This provides new information about pancreatic function when supplementing different zinc sources in the diets of late pregnant goats.
基金supported by the National Natural Science Foundation of China(Grants No.81872489 and 82073369)the Natural and Science Foundation of Sichuan Province(Grant No.2022NSFSC1412)。
文摘Dear Editor,Anaplastic lymphoma kinase(ALK)rearrangement is a key driver gene in non-small cell lung cancer(NSCLC),and the effectiveness of targeted therapies directed at ALK fusion has been confirmed.1 However,the activity of ALK-tyrosine kinase inhibitors(ALK-TKIs)against rare ALK rearrangements is variable,with limited clinical evidence.Here,we reported the case of a novel kinase D interacting substrate 220(KIDINS220)-ALK fusion that showed favorable response to alectinib.
基金The study was supported by Natural Science Founda—tion of Shaanxi Province of China (2003C134)．
文摘Using 2-3 weeks kid abomasums as materials, the ultrasound intensity, extracting time, NaCl concentration and pH valuein extracting solution and ratio of abomasums to extracting solution were studied by ultrasonic method. The resultsshowed that the main factor affecting kid rennet activity during extraction was ultrasound intensity, and then NaClconcentration, extracting time and ratio of abomasums to extracting solution in order. Kid rennet activity reached peakwith ultrasound intensity 30 W cm-2, extraction time 40 min, NaCl concentration 8%, pH value 3.0, ratio of abomasums toextracting solution 1:15.
