摘要
Zinc supplementation in the diet of goats affects pancreas development in offspring.However,the impact of maternal inorganic and organic zinc supplementation in offspring is poorly defined.In this study,14 late-pregnant goats were assigned at random to the zinc sulfate group(ZnSO_(4),n=7)and the zinc-glycine chelate group(Zn-Gly,n=7),respectively.Serum samples and pancreas tissue were collected from kids whose mothers were fed ZnSO_(4)and Zn-Gly at the late pregnancy,respectively.Histologic examination showed no morphologic differences between the 2 groups.Pancreatic zinc content in kids tended to be increased when replacing ZnSO_(4)with Zn-Gly.The serum insulin concentration was greater and glucagon less in the Zn-Gly group when compared to the ZnSO_(4)group.The activities of lipase and chymotrypsin were enhanced when replacing ZnSO_(4)with Zn-Gly.Proteomics results showed that 234 proteins were differentially expressed between the 2 groups,some of which were associated with the secretion of insulin,enzyme activity and signal transduction.The results suggested that supply of dietary Zn-Gly to goats during late pregnancy promoted pancreatic function in offspring compared with dietary ZnSO_(4)supplementation.This provides new information about pancreatic function when supplementing different zinc sources in the diets of late pregnant goats.
基金
The authors wish to acknowledge the financial support received from the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant NO.XDA 26040304)
Natural Science Foundation of Hunan Province(2020JJ5634)
National Natural Science Foundation of China(31760678).
