目的:探讨伐昔洛韦联合胎盘多肽注射液治疗复发性生殖器疱疹患者对炎性因子、免疫功能的影响。方法:将81例复发性生殖器疱疹患者随机分成观察组41例与对照组40例,两组患者均给予盐酸伐昔洛韦片口服,2次/d,0.3g/次,连续服用4周。观察组...目的:探讨伐昔洛韦联合胎盘多肽注射液治疗复发性生殖器疱疹患者对炎性因子、免疫功能的影响。方法:将81例复发性生殖器疱疹患者随机分成观察组41例与对照组40例,两组患者均给予盐酸伐昔洛韦片口服,2次/d,0.3g/次,连续服用4周。观察组在此基础上加用胎盘多肽注射液氯化钠注射液250m L静滴。比较两组患者治疗前后炎性因子、免疫功能变化以及临床疗效。结果:观察组治疗后IL-2、TNF-γ、CD4+、CD4+/CD8+均显著高于对照组(41.52±4.79 vs 22.03±2.31,12.62±2.85 vs 4.98±2.24,37.58±8.15 vs 32.16±3.85,1.32±0.26 vs 1.03±0.37),CD8+明显低于对照组(28.40±3.82 vs 30.82±4.64);治疗有效率明显高于对照组(95.12%vs 70.73%)。结论:昔洛韦联合胎盘多肽注射液有利于改善患者炎性症状和免疫功能,提高治疗效果。展开更多
目的:探讨康艾注射液辅助化疗治疗晚期肺癌的临床疗效及安全性。方法:选取2013年5月-2014年4月晚期肺癌患者146例,根据入院单双号分为观察组和对照组,各73例。对照组患者给予GP(吉西他滨+顺铂)方案化疗;观察组患者在对照组基础上加用康...目的:探讨康艾注射液辅助化疗治疗晚期肺癌的临床疗效及安全性。方法:选取2013年5月-2014年4月晚期肺癌患者146例,根据入院单双号分为观察组和对照组,各73例。对照组患者给予GP(吉西他滨+顺铂)方案化疗;观察组患者在对照组基础上加用康艾注射液60 m L加入生理盐水250 m L中,qd,ivgtt,每个化疗周期连用14 d。两组患者化疗期间均采用托烷司琼5 mg预防胃肠道反应。3周为一个疗程,两组患者均治疗3个疗程。比较两组患者临床疗效及治疗前后血清炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)、白细胞介素10(IL-10)]、免疫功能指标(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、肿瘤标志物[鳞状细胞癌相关抗原(SCC-Ag)、癌胚抗原(CEA)、糖类抗原(CA)50、CA72-4]水平,并记录不良反应发生情况。结果:观察组患者的临床有效率、疾病控制率分别为39.73%、84.93%,显著高于对照组的23.29%、71.23%,差异均有统计学意义(P<0.05)。治疗前,两组患者血清炎性因子、免疫指标、肿瘤标志物水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者hs-CRP、TNF-a、INF-γ水平均显著低于治疗前,IL-10显著高于治疗前,且观察组上述指标均显著优于于对照组,差异均有统计学意义(P<0.05);对照组CD4^+、CD4^+/CD8^+水平显示降低,且显著低于观察组,差异均有统计学意义(P<0.05);两组患者血清SCC-Ag、CEA、CA50、CA72-4水平均显著降低,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。观察组患者血小板减少、中性粒细胞减少、肝功能异常、恶心呕吐、贫血的发生率均显著低于对照组,差异均有统计学意义(P<0.05)。结论:康艾注射液辅助化疗能有效缓解晚期肺癌患者的炎症状态,减轻毒副反应,增强免疫功能,提高近期疗效,且安全性较高。展开更多
Objective:To evaluate the effect of Mycoplasma pneumoniae pneumonia (MPP) on inflammatory factors.Methods:Using the combination of subject terms and free words to search the literature on the effect of children with M...Objective:To evaluate the effect of Mycoplasma pneumoniae pneumonia (MPP) on inflammatory factors.Methods:Using the combination of subject terms and free words to search the literature on the effect of children with MPP on inflammatory factors.Retrieved from CNKI, VIP,CBM, Wanfang Database, Pubmed Database, Sciencedirect Database and Google scholor. etc.Time period of retrieval was from database established to May. 2019. 2 researchers conducted literature screening independently according to the inclusion and exclusion criteria. and then processed quality evaluation.RevMan5.3 and stata 14.0 were adopted to conduct Meta analysis on all effective indicators. Results:A total of 23 studies were involved, including 2254 children with MPP and 1182 healthy children. Results of Meta analysis showed IL-6 level(SMD=17.74, 95% CI =15.38~20.09,P<0.0001)、IL-8 level (SMD=19.40,95% CI=18.12~20.69,P<0.0001)、IL-10 level (SMD=9.51,95% CI =8.25~10.97,P<0.0001)、TNF-a level (SMD=31.06,95% CI =24.57~37.54,P<0.0001) were significantly better than the control group, the difference were statistically significant. Subgroup analysis:SMPP compared with MPP, IL-6 level (SMD=12.02, 95% CI =7.08~16.96,P<0.0001)was significantly better than the control group, the difference were statistically significant;Compared with the recovery period, the acute phase of children with MPP, IL-6 level (SMD=20.53, 95% CI =17.51~23.56,P<0.0001)、IL-8 level (SMD=17.27,95% CI=10.14~24.40,P<0.0001)、IL-10 level (SMD=6.04,95% CI =1.72~10.36,P<0.0001)、TNF-a level (SMD=23.64,95% CI =17.60~29.69,P<0.0001) were significantly better than the control group, the difference was statistically significant. Conclusions:MPP caused elevated levels of IL-6, IL-8, IL-10, and TNF-a inflammatory factors in the serum of children, and the levels of inflammatory factors were directly proportional to the severity of the disease.展开更多
目的探讨痰湿内阻慢性失眠大鼠模型建立及半夏秫米汤基于HPA轴、炎症因子的治疗机制。方法将48只Wistar大鼠随机分为空白组、痰湿内阻慢性失眠组及半夏秫米汤低、中、高剂量组和地西泮组,每组8只。高脂饲料+猪油灌胃7周后,继以单平台水...目的探讨痰湿内阻慢性失眠大鼠模型建立及半夏秫米汤基于HPA轴、炎症因子的治疗机制。方法将48只Wistar大鼠随机分为空白组、痰湿内阻慢性失眠组及半夏秫米汤低、中、高剂量组和地西泮组,每组8只。高脂饲料+猪油灌胃7周后,继以单平台水环境睡眠剥夺法3周复制痰湿内阻慢性失眠模型。空白组、痰湿内阻慢性失眠组予1 mL/100 g生理盐水灌胃,半夏秫米汤低、中、高剂量组按4.69、9.38、18.75 g/kg灌胃,地西泮组按0.75 mg/kg地西泮水溶液灌胃,每日1次,连续14 d。给药14 d后采用ELISA法检测HPA轴关键分子及炎症因子表达。结果与空白组相比,痰湿内阻慢性失眠模型组血清TG、LDL-C升高,HDL-C降低(P均<0.01);睡眠潜伏期延长,睡眠持续时间缩短(P<0.05);与痰湿内阻慢性失眠模型组相比,半夏秫米汤各给药组血清ACTH、CORT、CRH、GABA、NE、DA含量降低,下丘脑IL-1β、TNF-α降低,下丘脑IL-4、IL-10含量升高(P均<0.05)。结论高脂饲料+单平台水环境法复制痰湿内阻慢性失眠大鼠模型可行,半夏秫米汤干预痰湿内阻慢性失眠的作用机制是通过抑制亢进的HPA轴,调Shumi Decoction intervening chronic insomnia is achieved through inhibiting the hyperactive HPA axis and regulating the expression levels of inflammatory factors,GABA,NE,and DA.展开更多
文摘目的:探讨伐昔洛韦联合胎盘多肽注射液治疗复发性生殖器疱疹患者对炎性因子、免疫功能的影响。方法:将81例复发性生殖器疱疹患者随机分成观察组41例与对照组40例,两组患者均给予盐酸伐昔洛韦片口服,2次/d,0.3g/次,连续服用4周。观察组在此基础上加用胎盘多肽注射液氯化钠注射液250m L静滴。比较两组患者治疗前后炎性因子、免疫功能变化以及临床疗效。结果:观察组治疗后IL-2、TNF-γ、CD4+、CD4+/CD8+均显著高于对照组(41.52±4.79 vs 22.03±2.31,12.62±2.85 vs 4.98±2.24,37.58±8.15 vs 32.16±3.85,1.32±0.26 vs 1.03±0.37),CD8+明显低于对照组(28.40±3.82 vs 30.82±4.64);治疗有效率明显高于对照组(95.12%vs 70.73%)。结论:昔洛韦联合胎盘多肽注射液有利于改善患者炎性症状和免疫功能,提高治疗效果。
文摘目的:探讨康艾注射液辅助化疗治疗晚期肺癌的临床疗效及安全性。方法:选取2013年5月-2014年4月晚期肺癌患者146例,根据入院单双号分为观察组和对照组,各73例。对照组患者给予GP(吉西他滨+顺铂)方案化疗;观察组患者在对照组基础上加用康艾注射液60 m L加入生理盐水250 m L中,qd,ivgtt,每个化疗周期连用14 d。两组患者化疗期间均采用托烷司琼5 mg预防胃肠道反应。3周为一个疗程,两组患者均治疗3个疗程。比较两组患者临床疗效及治疗前后血清炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)、白细胞介素10(IL-10)]、免疫功能指标(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、肿瘤标志物[鳞状细胞癌相关抗原(SCC-Ag)、癌胚抗原(CEA)、糖类抗原(CA)50、CA72-4]水平,并记录不良反应发生情况。结果:观察组患者的临床有效率、疾病控制率分别为39.73%、84.93%,显著高于对照组的23.29%、71.23%,差异均有统计学意义(P<0.05)。治疗前,两组患者血清炎性因子、免疫指标、肿瘤标志物水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者hs-CRP、TNF-a、INF-γ水平均显著低于治疗前,IL-10显著高于治疗前,且观察组上述指标均显著优于于对照组,差异均有统计学意义(P<0.05);对照组CD4^+、CD4^+/CD8^+水平显示降低,且显著低于观察组,差异均有统计学意义(P<0.05);两组患者血清SCC-Ag、CEA、CA50、CA72-4水平均显著降低,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。观察组患者血小板减少、中性粒细胞减少、肝功能异常、恶心呕吐、贫血的发生率均显著低于对照组,差异均有统计学意义(P<0.05)。结论:康艾注射液辅助化疗能有效缓解晚期肺癌患者的炎症状态,减轻毒副反应,增强免疫功能,提高近期疗效,且安全性较高。
基金NSFC(No.81373687、81874490)Liaoning province"hundreds of thousands of talents project"candidate funding project(No.[2018]47)Shenyang science and technology innovation program for young and middle-aged talent(No.RC180246).
文摘Objective:To evaluate the effect of Mycoplasma pneumoniae pneumonia (MPP) on inflammatory factors.Methods:Using the combination of subject terms and free words to search the literature on the effect of children with MPP on inflammatory factors.Retrieved from CNKI, VIP,CBM, Wanfang Database, Pubmed Database, Sciencedirect Database and Google scholor. etc.Time period of retrieval was from database established to May. 2019. 2 researchers conducted literature screening independently according to the inclusion and exclusion criteria. and then processed quality evaluation.RevMan5.3 and stata 14.0 were adopted to conduct Meta analysis on all effective indicators. Results:A total of 23 studies were involved, including 2254 children with MPP and 1182 healthy children. Results of Meta analysis showed IL-6 level(SMD=17.74, 95% CI =15.38~20.09,P<0.0001)、IL-8 level (SMD=19.40,95% CI=18.12~20.69,P<0.0001)、IL-10 level (SMD=9.51,95% CI =8.25~10.97,P<0.0001)、TNF-a level (SMD=31.06,95% CI =24.57~37.54,P<0.0001) were significantly better than the control group, the difference were statistically significant. Subgroup analysis:SMPP compared with MPP, IL-6 level (SMD=12.02, 95% CI =7.08~16.96,P<0.0001)was significantly better than the control group, the difference were statistically significant;Compared with the recovery period, the acute phase of children with MPP, IL-6 level (SMD=20.53, 95% CI =17.51~23.56,P<0.0001)、IL-8 level (SMD=17.27,95% CI=10.14~24.40,P<0.0001)、IL-10 level (SMD=6.04,95% CI =1.72~10.36,P<0.0001)、TNF-a level (SMD=23.64,95% CI =17.60~29.69,P<0.0001) were significantly better than the control group, the difference was statistically significant. Conclusions:MPP caused elevated levels of IL-6, IL-8, IL-10, and TNF-a inflammatory factors in the serum of children, and the levels of inflammatory factors were directly proportional to the severity of the disease.
文摘目的探讨痰湿内阻慢性失眠大鼠模型建立及半夏秫米汤基于HPA轴、炎症因子的治疗机制。方法将48只Wistar大鼠随机分为空白组、痰湿内阻慢性失眠组及半夏秫米汤低、中、高剂量组和地西泮组,每组8只。高脂饲料+猪油灌胃7周后,继以单平台水环境睡眠剥夺法3周复制痰湿内阻慢性失眠模型。空白组、痰湿内阻慢性失眠组予1 mL/100 g生理盐水灌胃,半夏秫米汤低、中、高剂量组按4.69、9.38、18.75 g/kg灌胃,地西泮组按0.75 mg/kg地西泮水溶液灌胃,每日1次,连续14 d。给药14 d后采用ELISA法检测HPA轴关键分子及炎症因子表达。结果与空白组相比,痰湿内阻慢性失眠模型组血清TG、LDL-C升高,HDL-C降低(P均<0.01);睡眠潜伏期延长,睡眠持续时间缩短(P<0.05);与痰湿内阻慢性失眠模型组相比,半夏秫米汤各给药组血清ACTH、CORT、CRH、GABA、NE、DA含量降低,下丘脑IL-1β、TNF-α降低,下丘脑IL-4、IL-10含量升高(P均<0.05)。结论高脂饲料+单平台水环境法复制痰湿内阻慢性失眠大鼠模型可行,半夏秫米汤干预痰湿内阻慢性失眠的作用机制是通过抑制亢进的HPA轴,调Shumi Decoction intervening chronic insomnia is achieved through inhibiting the hyperactive HPA axis and regulating the expression levels of inflammatory factors,GABA,NE,and DA.
