目的探讨微信健康教育联合饮食运动干预对2型糖尿病合并牙周病患者牙周状况及生活质量的影响。方法对149例患者进行研究,随机分为对照组(n=74)和观察组(n=75)。对照组患者实施常规护理干预,观察组在对照组的基础上给予微信健康教育联合...目的探讨微信健康教育联合饮食运动干预对2型糖尿病合并牙周病患者牙周状况及生活质量的影响。方法对149例患者进行研究,随机分为对照组(n=74)和观察组(n=75)。对照组患者实施常规护理干预,观察组在对照组的基础上给予微信健康教育联合饮食运动干预。对比干预前后两组患者血糖控制情况、口腔健康情况、患者口腔护理知识及饮食依从性,并采用糖尿病患者生活质量量表(Diabetes mellitus quality of life scale,DMQLS)评估干预后患者的生活质量。结果观察组总有效率为98.61%,高于对照组的88.88%,差异有统计学意义(P<0.05);观察组空腹血糖、餐后2 h血糖值及糖化血红蛋白与对照组相比均较低,差异有统计学意义(P<0.05);干预前两组患者牙周检查指标无明显差异(P>0.05),干预后观察组牙周检查指标相比对照组有较大改善,差异有统计学意义(P<0.05);干预后观察组患者口腔保健知识及行为、饮食治疗依从性等与对照组比较具有明显差异(P<0.05);干预后观察组患者DMQLS评分明显高于对照组(P<0.05)。结论 2型糖尿病合并牙周病患者在进行微信健康教育联合个体化饮食及强化运动指导后,患者的血糖水平控制能力提高,牙周症状明显缓解,同时患者口腔保健及饮食控制的依从性提高,有利于提高患者生活质量。展开更多
Pancreaticβ-cell dysfunction and insulin resistance are two of the major causes of type 2 diabetes(T2D).Recent clinical and experimental studies have suggested that the functional capacity ofβ-cells,particularly in ...Pancreaticβ-cell dysfunction and insulin resistance are two of the major causes of type 2 diabetes(T2D).Recent clinical and experimental studies have suggested that the functional capacity ofβ-cells,particularly in the first phase of insulin secretion,is a primary contributor to the progression of T2D and its associated complications.Pancreaticβ-cells undergo dynamic compensation and decompensation processes during the development of T2D,in which metabolic stresses such as endoplasmic reticulum stress,oxidative stress,and inflammatory signals are key regulators ofβ-cell dynamics.Dietary and exercise interventions have been shown to be effective approaches for the treatment of obesity and T2D,especially in the early stages.Whilst the targeted tissues and underlying mechanisms of dietary and exercise interventions remain somewhat vague,accumulating evidence has implicated the improvement ofβ-cell functional capacity.In this review,we summarize recent advances in the understanding of the dynamic adaptations ofβ-cell function in T2D progression and clarify the effects and mechanisms of dietary and exercise interventions onβ-cell dysfunction in T2D.This review provides molecular insights into the therapeutic effects of dietary and exercise interventions on T2D,and more importantly,it paves the way for future research on the related underlying mechanisms for developing precision prevention and treatment of T2D.展开更多
文摘目的探讨微信健康教育联合饮食运动干预对2型糖尿病合并牙周病患者牙周状况及生活质量的影响。方法对149例患者进行研究,随机分为对照组(n=74)和观察组(n=75)。对照组患者实施常规护理干预,观察组在对照组的基础上给予微信健康教育联合饮食运动干预。对比干预前后两组患者血糖控制情况、口腔健康情况、患者口腔护理知识及饮食依从性,并采用糖尿病患者生活质量量表(Diabetes mellitus quality of life scale,DMQLS)评估干预后患者的生活质量。结果观察组总有效率为98.61%,高于对照组的88.88%,差异有统计学意义(P<0.05);观察组空腹血糖、餐后2 h血糖值及糖化血红蛋白与对照组相比均较低,差异有统计学意义(P<0.05);干预前两组患者牙周检查指标无明显差异(P>0.05),干预后观察组牙周检查指标相比对照组有较大改善,差异有统计学意义(P<0.05);干预后观察组患者口腔保健知识及行为、饮食治疗依从性等与对照组比较具有明显差异(P<0.05);干预后观察组患者DMQLS评分明显高于对照组(P<0.05)。结论 2型糖尿病合并牙周病患者在进行微信健康教育联合个体化饮食及强化运动指导后,患者的血糖水平控制能力提高,牙周症状明显缓解,同时患者口腔保健及饮食控制的依从性提高,有利于提高患者生活质量。
基金National Key Research and Development Programme of China(2018YFA0800403 and 2021YFC2701903)Training Program of the Major Research Plan of the National Natural Science Foundation of China(91857110)+6 种基金National Natural Science Fund for Excellent Young Scholars of China(81722012)National Natural Science Foundation of China(81670740)Zhejiang Provincial Natural Science Foundation of China(LZ21H070001)Innovative Institute of Basic Medical Sciences of Zhejiang University,the Fundamental Research Funds for the Central UniversitiesConstruction Fund of Medical Key Disciplines of Hangzhou(OO20200055)Hangzhou Science and Technology Bureau(20150733Q13 and ZD20200129)K.C.Wong Education Foundation.
文摘Pancreaticβ-cell dysfunction and insulin resistance are two of the major causes of type 2 diabetes(T2D).Recent clinical and experimental studies have suggested that the functional capacity ofβ-cells,particularly in the first phase of insulin secretion,is a primary contributor to the progression of T2D and its associated complications.Pancreaticβ-cells undergo dynamic compensation and decompensation processes during the development of T2D,in which metabolic stresses such as endoplasmic reticulum stress,oxidative stress,and inflammatory signals are key regulators ofβ-cell dynamics.Dietary and exercise interventions have been shown to be effective approaches for the treatment of obesity and T2D,especially in the early stages.Whilst the targeted tissues and underlying mechanisms of dietary and exercise interventions remain somewhat vague,accumulating evidence has implicated the improvement ofβ-cell functional capacity.In this review,we summarize recent advances in the understanding of the dynamic adaptations ofβ-cell function in T2D progression and clarify the effects and mechanisms of dietary and exercise interventions onβ-cell dysfunction in T2D.This review provides molecular insights into the therapeutic effects of dietary and exercise interventions on T2D,and more importantly,it paves the way for future research on the related underlying mechanisms for developing precision prevention and treatment of T2D.
