摘要
目的:建立IR动物模型和运动干预模型,为后续实验奠定基础。方法:46只雄性SD大鼠分4组:普食对照组、普食运动组、高脂膳食对照组、高脂膳食运动组。以高脂膳食诱导IR,同时运动组进行10周有氧游泳运动干预。综合利用体重、FINS、FBG、HOMA-IR、lSl、ITT指标评价动物模型的建立和运动干预的效果。结果:(1)E组和C组、H组和C组、HE组和H组间,体重、FINS和ISI有显著性著异(P<0.01或P<0.05);(2)ITT中,0时血糖无差异,在15min、30min、60min时间点,H组明显高于C组,HE组明显低于H组(P<0.05)。E组与C组比,15min、30min时明显下降(P<0.05)。结论:高脂膳食饲养10周可诱导正常SD大鼠出现IR;运动提高了大鼠胰岛素敏感性:间接评价IR指标中ISl较HOMA-IR敏感。
Insulin resistant rats and exercise intervention models were built in order to set foundation for subsequent work. 46 rats were divided into normal dietary control group, normal exercise group, high fat dietary control group and high fat dietary exercise group. High fat dietary were fed and exercise group were given aerobic swimming intervention for ten weeks. Body weight, FINS, FBG, HOMA-IR, ISI and insulin tolerant test were used to evaluate building of animal model and effect of exercise intervention. It was shown that between E and C, H and C, HE and H groups, there were significant differences on body weight, FINS and ISI （p〈 0.01 or p〈0.05）. In IET, blood of H group was significantly higher than that of C and that of HE was lower than that of C （p〈 0.05） at 15min, 30min and 60min. Compared with E, C was lower at 15min and 30min. It could be seen that ten weeks of high fat dietary feeding induced IR in SD rats. Exercise enhanced rats insulin sensitivity and indirect evaluation of IR, ISI was more sensitive than HOMA-IR.
出处
《武汉体育学院学报》
CSSCI
北大核心
2009年第8期51-54,71,共5页
Journal of Wuhan Sports University
基金
上海体科所横向资助课题(50602-316340)
关键词
IR
动物模型
高脂膳食
运动干预
评价
IR
animal model
high fat dietary
exercise intervention
evaluation
