Cell cycle progression is regulated by interactions between cyclins and cyclin-dependent kinases (CDKs). p21(WAF1) is one of the CIP/KIP family which inhibits CDKs activity. Increased expression of p21(WAF1) may play ...Cell cycle progression is regulated by interactions between cyclins and cyclin-dependent kinases (CDKs). p21(WAF1) is one of the CIP/KIP family which inhibits CDKs activity. Increased expression of p21(WAF1) may play an important role in the growth arrest induced in transformed cells. Although the stability of the p21( WAF1) mRNA could be altered by different signals, cell differentiation and numerous influencing factors. However, recent studies suggest that two known mechanisms of epigenesis, i.e.gene inactivation by methylation in promoter region and changes to an inactive chromatin by histone deacetylation, seem to be the best candidate mechanisms for inactivation of p21( WAF1). To date, almost no coding region p21(WAF1) mutations have been found in tumor cells, despite extensive screening of hundreds of various tumors. Hypermethylation of the p21(WAF1) promoter region may represent an alternative mechanism by which the p21(WAF1/CIP1) gene can be inactivated. The reduction of cellular DNMT protein levels also induces a corresponding rapid increase in the cell cycle regulator p21(WAF1) protein demonstrating a regulatory link between DNMT and p21(WAF1) which is independent of methylation of DNA. Both histone hyperacetylation and hypoacetylation appear to be important in the carcinoma process, and induction of the p21(WAF1) gene by histone hyperacetylation may be a mechanism by which dietary fiber prevents carcinogenesis. Here, we review the influence of histone acetylation and DNA methylation on p21(WAF1) transcription, and affection of pathways or factors associated such as p 53, E2A, Sp1 as well as several histone deacetylation inhibitors.展开更多
The high-energy consumption and high construction density of 5G base stations have greatly increased the demand for backup energy storage batteries.To maximize overall benefits for the investors and operators of base ...The high-energy consumption and high construction density of 5G base stations have greatly increased the demand for backup energy storage batteries.To maximize overall benefits for the investors and operators of base station energy storage,we proposed a bi-level optimization model for the operation of the energy storage,and the planning of 5G base stations considering the sleep mechanism.A multi-base station cooperative system composed of 5G acer stations was considered as the research object,and the outer goal was to maximize the net profit over the complete life cycle of the energy storage.Furthermore,the power and capacity of the energy storage configuration were optimized.The inner goal included the sleep mechanism of the base station,and the optimization of the energy storage charging and discharging strategy,for minimizing the daily electricity expenditure of the 5G base station system.Additionally,genetic algorithm and mixed integer programming were used to solve the bi-level optimization model,analyze the numerical example test comparison of the three types of batteries and the net income of the configuration,and finally verify the validity of the model.Furthermore,the sleep mechanism,the charging and discharging strategy for energy consumption,and the economic benefits for the operators were investigated to provide reference for the 5G base station energy storage configuration.展开更多
The strata of Jurassic was divided into three tectonic sequences and eight se- quences of third rank,according to the developing feature of the tectonic inconformity and the transforming feature of the depositional sy...The strata of Jurassic was divided into three tectonic sequences and eight se- quences of third rank,according to the developing feature of the tectonic inconformity and the transforming feature of the depositional system tracts.Also the identification and the division of the base-level cycle of different period were carried through.Therefore three cycles of super period,eight cycles of long period,twenty-four cycles of middle period and some cycles of short period were identified.From the overall character of the coal-accu- mulation in the Mesozoic,we can see that the Yan'an formation is of the best nature of coal bearing.When the coal bearing systems of Jurassic were depositing,the Ordos area is the coal accumulating basin of terrene of large scale and located in the same tectonic unit.But the local structure of different part and the paleolandform are different in the basin which resulted in the difference of the depositional environment.So the layer number and the distribution of the thickness of the coal beds are different in the different part of the ba- sin.The coal-accumulating action migrated regularly along with the development,evolve- ment and migration of the depositional systems.The layer numbers of the coal beds, which can be mined,are more in the north and west fringe of the basin,whose distributing area is extensive,and they are more steady in the landscape orientation,also the total thickness is great.Therefore the nature of coal bearing and the coal-accumulating action of different part changed obviously in the space in Ordos area.展开更多
In this paper we investigate cycle base structures of a (weighted) graph and show that much information of short cycles is contained in an MCB (i.e., minimum cycle base). After setting up a Hall type theorem for base-...In this paper we investigate cycle base structures of a (weighted) graph and show that much information of short cycles is contained in an MCB (i.e., minimum cycle base). After setting up a Hall type theorem for base-transformation, we give a sufficient and necessary condition for a cycle base to be an MCB. Furthermore, we show that the structure of MCB in a (weighted)graph is unique. The property is also true for those having a longest length (although much work has been down in evaluating MCB, little is known for those having a longest length). We use those methods to find out some unknown properties for short cycles sharing particular properties in (unweighted) graphs. As applications, we determine the structures of short cycles in an embedded graph and show that there exist polynomially bounded algorithms in finding a shortest contractible cycle and a shortest two-sided cycle provided such cycles exist. Those answer an open problem of B. Mohar and C. Thomassen.展开更多
In the South Yellow Sea Basin,Mesozoic–Paleozoic marine strata are generally well developed with large thickness,and no substantial breakthroughs have been made in hydrocarbon exploration.Through research,it is belie...In the South Yellow Sea Basin,Mesozoic–Paleozoic marine strata are generally well developed with large thickness,and no substantial breakthroughs have been made in hydrocarbon exploration.Through research,it is believed that the Upper Permian–Lower Triassic can be regarded as a long-term base-level cycle.Based on drilling data,characteristics of the lithology–electric property combination cyclicity,and the special lithology,the long-term base-level cycle was divided into five medium-term base-level cycles(MC1–MC5).On this basis,the Permian–Triassic sedimentary systems and their filling model were analyzed in accordance with the change of base-level cycle and transition of sedimentary environment,as well as characteristics of the drilling sedimentary facies and seismic facies.The results show that there were six sedimentary systems(fluvial,delta,tidal flat,open platform,restricted platform,and continental shelf)developed in the Upper Permian–Lower Triassic,the sedimentary systems were distributed such that the water was deep in the northwest and shallow in the southeast,and there were two base-level cycle filling models(a relatively stable tidal flat facies and a rapidly transgressive continental shelf facies to stable platform facies)developed in the Upper Permian–Lower Triassic.These models can provide a basis for evaluation of the Mesozoic–Paleozoic hydrocarbon geology in the South Yellow Sea Basin.展开更多
The advantage of high-resolution sequence stratigraphy, which takes base-levels as reference, is that it can be applied to continental depositional basins controlled by multiple factors and can effectively improve the...The advantage of high-resolution sequence stratigraphy, which takes base-levels as reference, is that it can be applied to continental depositional basins controlled by multiple factors and can effectively improve the accuracy and resolution of sequential stratigraphic analysis. Moreover, the principles of base-level cycles are also suitable for analyzing sequential stratigraphy in continental coal-bearing basins because of their accuracy in forecasting distribution of coal measures. By taking the Dongsheng coalfield in the Ordos basin as an example, the extensive application of base-level cycles in exploration and exploitation of coal is analyzed. The result shows that the Yan’an formation in the Dongsheng area is a long-term base-level cycle which is bordered by nonconformities and made up of five mid-term cycles and 13 short-term cycles. The long-term cycle and the mid-term cycles are obvious in comparison with a transverse profile. The episodic coal accumulation in the Mesozoic Ordos basin means that the deposition of primary matter (peat bogs) of coalification is discontinuous, periodical and cyclical in the evolution of the basin. The episodic accumulation of coal measures in the Yan’an stage is controlled by ascending-descending changes of a long-term cycle and middle-term cycles. Coal measures formed during the early and late periods of the long-term cycle are characterized by multiple layers, big cumulative thickness and poor continuity. Coal measures formed in the mid-term of the long cycle are dominated by good continuity, fewer layers and a small additive thickness, which is favorable for the accumulation of thick and continuous coal measures in the transition stage of mid term base-level cycles.展开更多
In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜ ＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G cont...In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜ ＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G contains a separating cycle, and G has a minor isomorphic to T6, where T6 is the graph obtained from the complete graph K6 by deleting a path with four edges.展开更多
Cycle base theory of a graph has been well studied in abstract mathematical field such matroid theory as Whitney and Tutte did and found many applications in prat-ical uses such as electric circuit theory and structur...Cycle base theory of a graph has been well studied in abstract mathematical field such matroid theory as Whitney and Tutte did and found many applications in prat-ical uses such as electric circuit theory and structure analysis, etc. In this paper graph embedding theory is used to investigate cycle base structures of a 2-(edge)-connected graph on the sphere and the projective plane and it is shown that short cycles do generate the cycle spaces in the case of 'small face-embeddings'. As applications the authors find the exact formulae for the minimum lengthes of cycle bases of some types of graphs and present several known results. Infinite examples shows that the conditions in their main results are best possible and there are many 3-connected planar graphs whose minimum cycle bases can not be determined by the planar formulae but may be located by re-embedding them into the projective plane.展开更多
In this paper we investigate cycle base structures of a （weighted） graph and show that much information of short cycles is contained in a MCB （minimum cycle base）. After setting up a Hall type theorem for base-tra...In this paper we investigate cycle base structures of a （weighted） graph and show that much information of short cycles is contained in a MCB （minimum cycle base）. After setting up a Hall type theorem for base-transformation, we give a sufficient and necessary condition for a cycle base to be a MCB. Further more, we show that the structure of MCB in a （weighted） graph is unique. In the case of nonnegative weight, every pair of MCB have the same number of k-cycles for each integer k ≥ 3. The property is also true for those having longest length （although much work has been down in evaluating MCB, little is known for those having longest length）.展开更多
文摘Cell cycle progression is regulated by interactions between cyclins and cyclin-dependent kinases (CDKs). p21(WAF1) is one of the CIP/KIP family which inhibits CDKs activity. Increased expression of p21(WAF1) may play an important role in the growth arrest induced in transformed cells. Although the stability of the p21( WAF1) mRNA could be altered by different signals, cell differentiation and numerous influencing factors. However, recent studies suggest that two known mechanisms of epigenesis, i.e.gene inactivation by methylation in promoter region and changes to an inactive chromatin by histone deacetylation, seem to be the best candidate mechanisms for inactivation of p21( WAF1). To date, almost no coding region p21(WAF1) mutations have been found in tumor cells, despite extensive screening of hundreds of various tumors. Hypermethylation of the p21(WAF1) promoter region may represent an alternative mechanism by which the p21(WAF1/CIP1) gene can be inactivated. The reduction of cellular DNMT protein levels also induces a corresponding rapid increase in the cell cycle regulator p21(WAF1) protein demonstrating a regulatory link between DNMT and p21(WAF1) which is independent of methylation of DNA. Both histone hyperacetylation and hypoacetylation appear to be important in the carcinoma process, and induction of the p21(WAF1) gene by histone hyperacetylation may be a mechanism by which dietary fiber prevents carcinogenesis. Here, we review the influence of histone acetylation and DNA methylation on p21(WAF1) transcription, and affection of pathways or factors associated such as p 53, E2A, Sp1 as well as several histone deacetylation inhibitors.
基金supported by the State Grid Science and Technology Project(KJ21-1-56).
文摘The high-energy consumption and high construction density of 5G base stations have greatly increased the demand for backup energy storage batteries.To maximize overall benefits for the investors and operators of base station energy storage,we proposed a bi-level optimization model for the operation of the energy storage,and the planning of 5G base stations considering the sleep mechanism.A multi-base station cooperative system composed of 5G acer stations was considered as the research object,and the outer goal was to maximize the net profit over the complete life cycle of the energy storage.Furthermore,the power and capacity of the energy storage configuration were optimized.The inner goal included the sleep mechanism of the base station,and the optimization of the energy storage charging and discharging strategy,for minimizing the daily electricity expenditure of the 5G base station system.Additionally,genetic algorithm and mixed integer programming were used to solve the bi-level optimization model,analyze the numerical example test comparison of the three types of batteries and the net income of the configuration,and finally verify the validity of the model.Furthermore,the sleep mechanism,the charging and discharging strategy for energy consumption,and the economic benefits for the operators were investigated to provide reference for the 5G base station energy storage configuration.
基金National Basis Research Program of China(2003CB214608)
文摘The strata of Jurassic was divided into three tectonic sequences and eight se- quences of third rank,according to the developing feature of the tectonic inconformity and the transforming feature of the depositional system tracts.Also the identification and the division of the base-level cycle of different period were carried through.Therefore three cycles of super period,eight cycles of long period,twenty-four cycles of middle period and some cycles of short period were identified.From the overall character of the coal-accu- mulation in the Mesozoic,we can see that the Yan'an formation is of the best nature of coal bearing.When the coal bearing systems of Jurassic were depositing,the Ordos area is the coal accumulating basin of terrene of large scale and located in the same tectonic unit.But the local structure of different part and the paleolandform are different in the basin which resulted in the difference of the depositional environment.So the layer number and the distribution of the thickness of the coal beds are different in the different part of the ba- sin.The coal-accumulating action migrated regularly along with the development,evolve- ment and migration of the depositional systems.The layer numbers of the coal beds, which can be mined,are more in the north and west fringe of the basin,whose distributing area is extensive,and they are more steady in the landscape orientation,also the total thickness is great.Therefore the nature of coal bearing and the coal-accumulating action of different part changed obviously in the space in Ordos area.
基金supported by the National Natural Science Foundation of China(Grant No.10271048)the first author also acknowledges the financial support of Shanghai Priority Academic Disciplinethe fund of the Science and Technology Commission of Shanghai Municipality(Grant No.04JC14031).
文摘In this paper we investigate cycle base structures of a (weighted) graph and show that much information of short cycles is contained in an MCB (i.e., minimum cycle base). After setting up a Hall type theorem for base-transformation, we give a sufficient and necessary condition for a cycle base to be an MCB. Furthermore, we show that the structure of MCB in a (weighted)graph is unique. The property is also true for those having a longest length (although much work has been down in evaluating MCB, little is known for those having a longest length). We use those methods to find out some unknown properties for short cycles sharing particular properties in (unweighted) graphs. As applications, we determine the structures of short cycles in an embedded graph and show that there exist polynomially bounded algorithms in finding a shortest contractible cycle and a shortest two-sided cycle provided such cycles exist. Those answer an open problem of B. Mohar and C. Thomassen.
基金Projects(41506080,41702162)supported by the National Natural Science Foundation of ChinaProjects(DD20160152,DD20160147,GZH200800503)supported by China Geological Survey+1 种基金Projects(XQ-2005-01,2009GYXQ10)supported by China Ministry of Land and ResourcesProject(201602004)supported by the Postdoctoral Innovation Foundation of Shandong Province,China
文摘In the South Yellow Sea Basin,Mesozoic–Paleozoic marine strata are generally well developed with large thickness,and no substantial breakthroughs have been made in hydrocarbon exploration.Through research,it is believed that the Upper Permian–Lower Triassic can be regarded as a long-term base-level cycle.Based on drilling data,characteristics of the lithology–electric property combination cyclicity,and the special lithology,the long-term base-level cycle was divided into five medium-term base-level cycles(MC1–MC5).On this basis,the Permian–Triassic sedimentary systems and their filling model were analyzed in accordance with the change of base-level cycle and transition of sedimentary environment,as well as characteristics of the drilling sedimentary facies and seismic facies.The results show that there were six sedimentary systems(fluvial,delta,tidal flat,open platform,restricted platform,and continental shelf)developed in the Upper Permian–Lower Triassic,the sedimentary systems were distributed such that the water was deep in the northwest and shallow in the southeast,and there were two base-level cycle filling models(a relatively stable tidal flat facies and a rapidly transgressive continental shelf facies to stable platform facies)developed in the Upper Permian–Lower Triassic.These models can provide a basis for evaluation of the Mesozoic–Paleozoic hydrocarbon geology in the South Yellow Sea Basin.
基金Project2003CB214603 supported by Development Plan of the State Key Fundamental Research, China
文摘The advantage of high-resolution sequence stratigraphy, which takes base-levels as reference, is that it can be applied to continental depositional basins controlled by multiple factors and can effectively improve the accuracy and resolution of sequential stratigraphic analysis. Moreover, the principles of base-level cycles are also suitable for analyzing sequential stratigraphy in continental coal-bearing basins because of their accuracy in forecasting distribution of coal measures. By taking the Dongsheng coalfield in the Ordos basin as an example, the extensive application of base-level cycles in exploration and exploitation of coal is analyzed. The result shows that the Yan’an formation in the Dongsheng area is a long-term base-level cycle which is bordered by nonconformities and made up of five mid-term cycles and 13 short-term cycles. The long-term cycle and the mid-term cycles are obvious in comparison with a transverse profile. The episodic coal accumulation in the Mesozoic Ordos basin means that the deposition of primary matter (peat bogs) of coalification is discontinuous, periodical and cyclical in the evolution of the basin. The episodic accumulation of coal measures in the Yan’an stage is controlled by ascending-descending changes of a long-term cycle and middle-term cycles. Coal measures formed during the early and late periods of the long-term cycle are characterized by multiple layers, big cumulative thickness and poor continuity. Coal measures formed in the mid-term of the long cycle are dominated by good continuity, fewer layers and a small additive thickness, which is favorable for the accumulation of thick and continuous coal measures in the transition stage of mid term base-level cycles.
文摘In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜ ＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G contains a separating cycle, and G has a minor isomorphic to T6, where T6 is the graph obtained from the complete graph K6 by deleting a path with four edges.
文摘Cycle base theory of a graph has been well studied in abstract mathematical field such matroid theory as Whitney and Tutte did and found many applications in prat-ical uses such as electric circuit theory and structure analysis, etc. In this paper graph embedding theory is used to investigate cycle base structures of a 2-(edge)-connected graph on the sphere and the projective plane and it is shown that short cycles do generate the cycle spaces in the case of 'small face-embeddings'. As applications the authors find the exact formulae for the minimum lengthes of cycle bases of some types of graphs and present several known results. Infinite examples shows that the conditions in their main results are best possible and there are many 3-connected planar graphs whose minimum cycle bases can not be determined by the planar formulae but may be located by re-embedding them into the projective plane.
基金Supported by the National Natural Science Foundation of China(No.10271048,10671073)Supported by Shanghai Leading Academic Discipline Project(No.B407)Science and Technology Commission of Shanghai Municipality(No.07XD14011)
文摘In this paper we investigate cycle base structures of a （weighted） graph and show that much information of short cycles is contained in a MCB （minimum cycle base）. After setting up a Hall type theorem for base-transformation, we give a sufficient and necessary condition for a cycle base to be a MCB. Further more, we show that the structure of MCB in a （weighted） graph is unique. In the case of nonnegative weight, every pair of MCB have the same number of k-cycles for each integer k ≥ 3. The property is also true for those having longest length （although much work has been down in evaluating MCB, little is known for those having longest length）.
