Aim A new proliposomal technology was used to trap several drugs,such as tegafur,silymarin,cistanosides,oleanolic acid.And then these proliposomal characters were studied.Methods These proliposomes formed liposomes af...Aim A new proliposomal technology was used to trap several drugs,such as tegafur,silymarin,cistanosides,oleanolic acid.And then these proliposomal characters were studied.Methods These proliposomes formed liposomes after mixing with water.And then the liposomal morphology was determined by electron microscope,and the liposomal particle size determined by particle sizes instrument.The trap efficiency was determined by the column chromatography,and then the influence factors on the trap efficiency were investigated.Results The liposomes looked round,some with multiply layers,the particle was small,and the ξ potential was about-30 mV.The trap efficiency changed with the partition coefficient and pH.When the partition coefficient and pH increased,the trap efficiency increased.Furthermore,the trap efficiency was not influenced by the molecular weight.Conclusion This kind of liposomal technology trapped the drugs efficiently,and the lipophilic drugs were trapped more easily.Some Chinese traditional drugs could be trapped too.展开更多
本文采用水溶性微粉薄膜法(water-soluble powder thin film method)制备了阿霉素前体脂质体制剂,并对其质量进行了评定。结果表明,本法制备的阿霉素前体脂质体是附着磷脂薄膜的甘露醇微粉,与含阿霉素(ling/ml)的水相混合后,形成类似椭...本文采用水溶性微粉薄膜法(water-soluble powder thin film method)制备了阿霉素前体脂质体制剂,并对其质量进行了评定。结果表明,本法制备的阿霉素前体脂质体是附着磷脂薄膜的甘露醇微粉,与含阿霉素(ling/ml)的水相混合后,形成类似椭圆状的脂质体。算术平均粒径为 1.3μm,包封率可达55.5%±3.8%。展开更多
文摘Aim A new proliposomal technology was used to trap several drugs,such as tegafur,silymarin,cistanosides,oleanolic acid.And then these proliposomal characters were studied.Methods These proliposomes formed liposomes after mixing with water.And then the liposomal morphology was determined by electron microscope,and the liposomal particle size determined by particle sizes instrument.The trap efficiency was determined by the column chromatography,and then the influence factors on the trap efficiency were investigated.Results The liposomes looked round,some with multiply layers,the particle was small,and the ξ potential was about-30 mV.The trap efficiency changed with the partition coefficient and pH.When the partition coefficient and pH increased,the trap efficiency increased.Furthermore,the trap efficiency was not influenced by the molecular weight.Conclusion This kind of liposomal technology trapped the drugs efficiently,and the lipophilic drugs were trapped more easily.Some Chinese traditional drugs could be trapped too.
