Aim: To correlate obstetric data with the appearance of antithyroid antibodies. Methods: A 6 months follow up was performed on 135 healthy women with assessment of TSH, T3, T4 and antithyroid antibodies (anti thyroglo...Aim: To correlate obstetric data with the appearance of antithyroid antibodies. Methods: A 6 months follow up was performed on 135 healthy women with assessment of TSH, T3, T4 and antithyroid antibodies (anti thyroglobulin and anti peroxidase). Correlation of diverse obstetrical parameters with the appearance of antithyroid antibodies at 2 and 6 months postpartum was determined. Results: Only two parameters were significant during the complete follow up: the newborn weight, which correlated with both antibodies (anti-thyroglobulin and anti-peroxidase) positivity and the maternal height, which exclusively correlated with anti-thyroglobulin positivity. Conclusions: Correlation of maternal height and newborn weight with positive autoantibodies allows to consider a future clinical screening test for this disorder.展开更多
目的探究与分析甲状腺过氧化物酶抗体(TPO-Ab)滴度与B超对产后甲状腺炎(PPT)患者的诊断价值。方法选取自2013年5月起至2015年4月接受治疗的产后甲状腺炎患者96例作为调查研究对象,收集其确诊时TPO-Ab滴度、游离三碘甲状腺原氨酸(FT3)、...目的探究与分析甲状腺过氧化物酶抗体(TPO-Ab)滴度与B超对产后甲状腺炎(PPT)患者的诊断价值。方法选取自2013年5月起至2015年4月接受治疗的产后甲状腺炎患者96例作为调查研究对象,收集其确诊时TPO-Ab滴度、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)及甲状腺B超检查结果,并进行18个月的产后随访。分析研究患者TPO-Ab、甲状腺功能变化及超声检查情况。结果 1产后甲状腺炎患者临床表现多样,既可以表现为甲减,也可以表现为甲亢。2TPO-Ab滴度检测结果:96例患者确诊检查时,72例(75.00%)为TPO-Ab阳性,74例出现甲亢症状,22例出现甲减症状;96例患者经治疗后,进行为期18个月的随访,由随访结果可知仍有17例(17.71%)患者TSH<0.30 m U/L。3甲状腺B超检测结果:96例患者均表现为双侧甲状腺弥漫性增大,回声类型共分为三种,其中A型(回声正常)10例,B型(回声分布不均匀)22例,C型(回声弥漫性降低)64例。96例患者进行为期18个月的随访,由随访结果可知,10例回声正常者,其TSH值也恢复至正常范围;22例回声不均匀者,2例TSH>4.8 m U/L;64例回声弥漫性降低者,7例TSH>4.8 m U/L。4两种诊疗方法结果对比:C型组TPO-Ab滴度、TSH值均明显高于A型组与B型组,差异对比,统计学上有意义(P<0.05)。结论甲状腺B超检测无明显特异性,结合TPO-Ab滴度后诊断价值更高,结果更为准确,同时,超声图像中的回声范围与TPO-Ab滴度及甲状腺功能损害情况密切相关。展开更多
文摘Aim: To correlate obstetric data with the appearance of antithyroid antibodies. Methods: A 6 months follow up was performed on 135 healthy women with assessment of TSH, T3, T4 and antithyroid antibodies (anti thyroglobulin and anti peroxidase). Correlation of diverse obstetrical parameters with the appearance of antithyroid antibodies at 2 and 6 months postpartum was determined. Results: Only two parameters were significant during the complete follow up: the newborn weight, which correlated with both antibodies (anti-thyroglobulin and anti-peroxidase) positivity and the maternal height, which exclusively correlated with anti-thyroglobulin positivity. Conclusions: Correlation of maternal height and newborn weight with positive autoantibodies allows to consider a future clinical screening test for this disorder.
文摘目的探究与分析甲状腺过氧化物酶抗体(TPO-Ab)滴度与B超对产后甲状腺炎(PPT)患者的诊断价值。方法选取自2013年5月起至2015年4月接受治疗的产后甲状腺炎患者96例作为调查研究对象,收集其确诊时TPO-Ab滴度、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)及甲状腺B超检查结果,并进行18个月的产后随访。分析研究患者TPO-Ab、甲状腺功能变化及超声检查情况。结果 1产后甲状腺炎患者临床表现多样,既可以表现为甲减,也可以表现为甲亢。2TPO-Ab滴度检测结果:96例患者确诊检查时,72例(75.00%)为TPO-Ab阳性,74例出现甲亢症状,22例出现甲减症状;96例患者经治疗后,进行为期18个月的随访,由随访结果可知仍有17例(17.71%)患者TSH<0.30 m U/L。3甲状腺B超检测结果:96例患者均表现为双侧甲状腺弥漫性增大,回声类型共分为三种,其中A型(回声正常)10例,B型(回声分布不均匀)22例,C型(回声弥漫性降低)64例。96例患者进行为期18个月的随访,由随访结果可知,10例回声正常者,其TSH值也恢复至正常范围;22例回声不均匀者,2例TSH>4.8 m U/L;64例回声弥漫性降低者,7例TSH>4.8 m U/L。4两种诊疗方法结果对比:C型组TPO-Ab滴度、TSH值均明显高于A型组与B型组,差异对比,统计学上有意义(P<0.05)。结论甲状腺B超检测无明显特异性,结合TPO-Ab滴度后诊断价值更高,结果更为准确,同时,超声图像中的回声范围与TPO-Ab滴度及甲状腺功能损害情况密切相关。
