目的:探讨骨髓水肿与重度膝骨关节炎病理改变及症状体征的关系。方法:自2020年1月至2021年3月于中国中医科学院望京医院骨关节科就诊已行膝关节MRI检查的重度膝骨关节炎患者160例。合并骨髓水肿患者80例为病例组,男12例,女68例,年龄51~8...目的:探讨骨髓水肿与重度膝骨关节炎病理改变及症状体征的关系。方法:自2020年1月至2021年3月于中国中医科学院望京医院骨关节科就诊已行膝关节MRI检查的重度膝骨关节炎患者160例。合并骨髓水肿患者80例为病例组,男12例,女68例,年龄51~80(66.58±8.10)岁,病程5~40(15.61±9.25)个月,身体质量指数(body mass index,BMI)21.81~34.70(27.79±3.00)kg·m^(-2);不合并骨髓水肿的患者80例为对照组,男15例,女65例,年龄50~80(67.82±8.05)岁,病程6~37(15.75±8.18)个月,BMI 21.39~34.46(28.26±3.13)kg·m^(-2)。采用膝关节整体磁共振成像评分(whole oragan magnetic resonance imaging score,WORMS)评价骨髓水肿程度,采用Kellgren-Lawrence(K-L)等级、Western Outario and McMaster大学骨关节炎指数评分(Western Ontario and McMaster University osteoarthritis index,WOMAC)评价膝骨关节炎病变程度,采用视觉模拟评分(visual analogue scale,VAS),WOMAC疼痛评分评价关节疼痛程度,采用压痛、叩击痛、关节肿胀度、关节活动度评分评价关节体征。比较两组患者K-L等级分布的差异探讨骨髓水肿与膝骨关节炎病变程度的关系;并进一步通过Spearman相关性分析病例组患者骨髓水肿WORMS评分与WOMAC指数、疼痛相关评分、体征相关评分的相关系数,以进一步探讨骨髓水肿与膝骨关节炎指数、关节疼痛症状、体征的关系。结果:病例组患者K-L等级Ⅳ级者占68.75%(55/80),对照组患者等级Ⅳ级者占52.50%(42/80),病例组中Ⅳ级患者所占比例高于对照组(χ^(2)=4.425,P<0.05)。病例组患者骨髓水肿WORMS与膝骨关节炎WOMAC指数相关系数为强正相关(r=0.873>0.8,P<0.001),骨髓水肿WORMS与VAS相关系数r=0.752>0.5,与WOMAC量表疼痛评分相关系数r=0.650>0.5,为中度相关(P<0.001);骨髓水肿WORMS与叩击痛评分相关系数r=0.784>0.5,(P<0.001),为中度相关(P<0.05);骨髓水肿WORMS评分与压痛评分相关系数r=0.194<0.3、关节肿胀度评分相关系数r=0.2展开更多
Background Abdominal pain is a common symptom among patients with acute appendicitis, yet these patients have long been denied relief from suffering because of widespread misconceptions associated with the use of opio...Background Abdominal pain is a common symptom among patients with acute appendicitis, yet these patients have long been denied relief from suffering because of widespread misconceptions associated with the use of opioids. We determined whether morphine hydrochloride masked the physical signs in adults with acute appendicitis and assessed the efficacy of morphine in relieving abdominal pain. Methods A prospective, double-blind, placebo controlled, clinical trial was conducted with 106 adult patients between 16 and 70 years old with acute appendicitis. Patients were randomly divided into a morphine group （n=-54） or a normal saline group （n=52）. All patients presented with acute abdominal pain with onset within 3 days. The morphine group received hypodermic injection of morphine （0.15 mg/kg; maximum 20 mg） and the control group members were given an equivalent volume of normal saline solution. The clinical symptoms, physical signs, and patients＇ cooperation during physical examination were assessed before and after 30 minutes of morphine or normal saline administration. Results Abdominal pain was significantly relieved and the patients＇ cooperation was improved in the morphine group after 30 minutes treatment compared with the control group and before morphine administration （P 〈0.05）. The physical signs were unaffected by either treatment （P 〉0.05）. Conclusions Morphine relieved abdominal pain and improved the patients＇ cooperation for treatment and care. Furthermore, the morphine did not mask the physical signs of acute appendicitis.展开更多
文摘目的:探讨骨髓水肿与重度膝骨关节炎病理改变及症状体征的关系。方法:自2020年1月至2021年3月于中国中医科学院望京医院骨关节科就诊已行膝关节MRI检查的重度膝骨关节炎患者160例。合并骨髓水肿患者80例为病例组,男12例,女68例,年龄51~80(66.58±8.10)岁,病程5~40(15.61±9.25)个月,身体质量指数(body mass index,BMI)21.81~34.70(27.79±3.00)kg·m^(-2);不合并骨髓水肿的患者80例为对照组,男15例,女65例,年龄50~80(67.82±8.05)岁,病程6~37(15.75±8.18)个月,BMI 21.39~34.46(28.26±3.13)kg·m^(-2)。采用膝关节整体磁共振成像评分(whole oragan magnetic resonance imaging score,WORMS)评价骨髓水肿程度,采用Kellgren-Lawrence(K-L)等级、Western Outario and McMaster大学骨关节炎指数评分(Western Ontario and McMaster University osteoarthritis index,WOMAC)评价膝骨关节炎病变程度,采用视觉模拟评分(visual analogue scale,VAS),WOMAC疼痛评分评价关节疼痛程度,采用压痛、叩击痛、关节肿胀度、关节活动度评分评价关节体征。比较两组患者K-L等级分布的差异探讨骨髓水肿与膝骨关节炎病变程度的关系;并进一步通过Spearman相关性分析病例组患者骨髓水肿WORMS评分与WOMAC指数、疼痛相关评分、体征相关评分的相关系数,以进一步探讨骨髓水肿与膝骨关节炎指数、关节疼痛症状、体征的关系。结果:病例组患者K-L等级Ⅳ级者占68.75%(55/80),对照组患者等级Ⅳ级者占52.50%(42/80),病例组中Ⅳ级患者所占比例高于对照组(χ^(2)=4.425,P<0.05)。病例组患者骨髓水肿WORMS与膝骨关节炎WOMAC指数相关系数为强正相关(r=0.873>0.8,P<0.001),骨髓水肿WORMS与VAS相关系数r=0.752>0.5,与WOMAC量表疼痛评分相关系数r=0.650>0.5,为中度相关(P<0.001);骨髓水肿WORMS与叩击痛评分相关系数r=0.784>0.5,(P<0.001),为中度相关(P<0.05);骨髓水肿WORMS评分与压痛评分相关系数r=0.194<0.3、关节肿胀度评分相关系数r=0.2
文摘Background Abdominal pain is a common symptom among patients with acute appendicitis, yet these patients have long been denied relief from suffering because of widespread misconceptions associated with the use of opioids. We determined whether morphine hydrochloride masked the physical signs in adults with acute appendicitis and assessed the efficacy of morphine in relieving abdominal pain. Methods A prospective, double-blind, placebo controlled, clinical trial was conducted with 106 adult patients between 16 and 70 years old with acute appendicitis. Patients were randomly divided into a morphine group （n=-54） or a normal saline group （n=52）. All patients presented with acute abdominal pain with onset within 3 days. The morphine group received hypodermic injection of morphine （0.15 mg/kg; maximum 20 mg） and the control group members were given an equivalent volume of normal saline solution. The clinical symptoms, physical signs, and patients＇ cooperation during physical examination were assessed before and after 30 minutes of morphine or normal saline administration. Results Abdominal pain was significantly relieved and the patients＇ cooperation was improved in the morphine group after 30 minutes treatment compared with the control group and before morphine administration （P 〈0.05）. The physical signs were unaffected by either treatment （P 〉0.05）. Conclusions Morphine relieved abdominal pain and improved the patients＇ cooperation for treatment and care. Furthermore, the morphine did not mask the physical signs of acute appendicitis.
