Cardiovascular disease including stroke is a major complication that tremendously increases the morbidity and mortality in patients with diabetes mellitus(DM). DM poses about four times higher risk for stroke. Cardiom...Cardiovascular disease including stroke is a major complication that tremendously increases the morbidity and mortality in patients with diabetes mellitus(DM). DM poses about four times higher risk for stroke. Cardiometabolic risk factors including obesity, hypertension, and dyslipidaemia often co-exist in patients with DM that add on to stroke risk. Because of the strong association between DM and other stroke risk factors, physicians and diabetologists managing patients should have thorough understanding of these risk factors and management. This review is an evidence-based approach to the epidemiological aspects, pathophysiology, diagnostic work up and management algorithms for patients with diabetes and stroke.展开更多
文摘Cardiovascular disease including stroke is a major complication that tremendously increases the morbidity and mortality in patients with diabetes mellitus(DM). DM poses about four times higher risk for stroke. Cardiometabolic risk factors including obesity, hypertension, and dyslipidaemia often co-exist in patients with DM that add on to stroke risk. Because of the strong association between DM and other stroke risk factors, physicians and diabetologists managing patients should have thorough understanding of these risk factors and management. This review is an evidence-based approach to the epidemiological aspects, pathophysiology, diagnostic work up and management algorithms for patients with diabetes and stroke.
文摘高血糖出现之前的早期异常代谢环境中,炎症和胰岛素抵抗(insulin resistance,IR)是引起"代谢记忆"现象的重要因素;高血糖刺激后细胞活性氧过度生成、蛋白激酶C活化、炎症介质表达失调、细胞凋亡、线粒体DNA持续损伤、DNA甲基化;高血糖得以良好控制后,凋亡相关基因仍处于高表达状态,氧化应激、硝化应激和晚期糖基化终产物(advanced glycation end products,AGEs)三者相互作用,引起高血糖"代谢记忆"现象。文中就影响"糖尿病代谢记忆"的主要因素作一综述。
