摘要
代谢记忆是有效管理糖尿病并发症的主要障碍,仅通过药物控制血糖水平并不能同时防治糖尿病相关的多种并发症发生。因此,了解其介导糖尿病并发症发生的分子机制,有助于对预防和消除"代谢记忆"效应进行更深入的研究。本文将对受代谢记忆影响的相关糖尿病并发症、代谢记忆介导糖尿病并发症发生的分子机制以及预期的治疗药物进行综述,为防治代谢记忆的进一步研究提供依据。
At present,metabolic memory is a major obstacle hindering the effective control of diabetes.Controlling blood sugar level solely by drugs can not prevent multiple diabetic complications.Understanding the molecular mechanisms of mediating diabetic complications,therefore,will eliminate the ＂metabolic memory＂effect.In this artical,the molecular mechanism of metabolic memory mediating diabetic complications and prospective treatment drugs were reviewed,which provides basis to the further research on prevention and treatment of metabolic memory.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2017年第5期622-628,共7页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助项目(No.81473216
No.81673435)~~
关键词
代谢记忆
糖尿病并发症
治疗策略
metabolic memory
diabetic complication
treatment strategy
