摘要
近年来大量循证医学证据表明了血糖控制在早期强化的重要性,并且在一段时间内改善血糖控制后,仍有并发症发生,机体的这种早期高血糖存在记忆的状态称为“代谢记忆”。由于代谢记忆的存在,临床以控制血糖为重点的干预方式无法有效阻止糖尿病大血管病变的发生发展,如何正确认识并阻止代谢记忆,成为目前糖尿病大血管病变临床防治的重要核心之一。本文从分子生物学、表观遗传学、妊娠糖尿病影响、血液流变学等方面综述了近几年糖尿病“代谢记忆”研究进展,为今后的基础研究和临床防治提供参考依据。
In recent years,a large number of evidence-based medical evidence,such as the UK Prospective Diabetes Study(UKPDS),have demonstrated the importance of early glycaemic control for glycemic control,and there are still complications after improving glycemic control over a period of time.The state of memory in which early hyperglycemia exists is called"metabolic memory."Due to the existence of metabolic memory,clinical interventions that focus on blood glucose control can not effectively prevent the development of diabetic macroangiopathy.How to correctly recognize and prevent metabolic memory has become one of the most important clinical prevention and treatment of diabetic macroangiopathy.This article reviews the progress of research on diabetes"metabolic memory"in recent years from the aspects of molecular biology,epigenetics,gestational diabetes,and hemorheology,and provides reference for basic research and clinical prevention in the future.
作者
鄢然
杨婵
蔡雪琴
谢春光
Yan Ran;Yang Chan;Cai Xueqin;Xie Chunguang(Chengdu University of Traditional Chinese Medicine,Chengdu,610075,China;Department of Endocrinology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,610075,China)
出处
《成都中医药大学学报》
2019年第2期69-73,共5页
Journal of Chengdu University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(81774302)
国家中医药管理局基金资助项目(JDZX2015212)
四川省中医药管理局基金资助项目(2016Q022)
关键词
糖尿病
代谢记忆
影响因素
Diabetes
Metabolic memory
Influencing factors
